公开(公告)号：US20230232797A1

公开(公告)日：2023-07-27

申请号：US18175010

申请日：2023-02-27

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Qing Fang ,  Chia-Jen Siao ,  Dan Chalothorn ,  KehDih Lai ,  Leah Sabin ,  Rachel Sattler ,  Brian Zambrowicz ,  Lori Morton

IPC分类号： A01K67/027 ,  A61K49/00 ,  C07K14/76 ,  C12N15/85

CPC分类号： A01K67/0278 ,  A61K49/0008 ,  C07K14/76 ,  C12N15/8509 ,  A01K2207/15 ,  A01K2227/105 ,  A01K2267/03 ,  C12N2015/8527

摘要： Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized albumin (ALB) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized albumin locus express a human albumin protein or a chimeric albumin protein, fragments of which are from human albumin. Methods are provided for using such non-human animals comprising a humanized albumin locus to assess in vivo efficacy of human-albumin-targeting reagents such as nuclease agents designed to target human albumin.

公开(公告)号：US20210274759A1

公开(公告)日：2021-09-09

申请号：US17190650

申请日：2021-03-03

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Giusy Della Gatta ,  Qing Fang ,  Alan Shuldiner

IPC分类号： A01K67/027 ,  C12N15/11 ,  C12N9/22 ,  C12N9/10

摘要： This disclosure relates to genetically modified animals. More specifically, this disclosure relates to rodent animals in which an endogenous B4galt1 gene has been modified, e.g., to introduce a mutation that encodes an Asn to Ser substitution in the encoded B4galt1 protein at a position corresponding to position 352 in a human B4GALT1 protein, or to introduce a loss of function mutation (e.g., in a select tissue such as the liver). This disclosure also relates to use of such rodent animals in elucidating the role of B4galt1 in lipid metabolism.

公开(公告)号：US11622547B2

公开(公告)日：2023-04-11

申请号：US16894302

申请日：2020-06-05

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Qing Fang ,  Chia-Jen Siao ,  Dan Chalothorn ,  KehDih Lai ,  Leah Sabin ,  Rachel Sattler ,  Brian Zambrowicz ,  Lori Morton

IPC分类号： A01K67/027 ,  A61K49/00 ,  C07K14/76 ,  C12N15/85

摘要： Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized albumin (ALB) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized albumin locus express a human albumin protein or a chimeric albumin protein, fragments of which are from human albumin. Methods are provided for using such non-human animals comprising a humanized albumin locus to assess in vivo efficacy of human-albumin-targeting reagents such as nuclease agents designed to target human albumin.