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公开(公告)号:US20060166218A1
公开(公告)日:2006-07-27
申请号:US10939121
申请日:2004-09-10
申请人: Reid Orth , David Lin , Theodore Clark , Yung-Fu Chang , Harold Craighead , Jose Moran-Mirabal
发明人: Reid Orth , David Lin , Theodore Clark , Yung-Fu Chang , Harold Craighead , Jose Moran-Mirabal
CPC分类号: B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659
摘要: An array is formed with a protective cover on a substrate. The protective cover is patterned to produce an array of openings to the substrate. Desired material is deposited on the substrate through the openings. The protective cover may then be removed. In one embodiment, the protective cover is a conformal polymer, such as di-para-xylylene. It may be removed by mechanical peeling. The material may be biological material such as DNA. The protective cover may be used to prevent non-specific hybridization in inter-spot regions by performing hybridization with the cover still in place. Hybridization that occurs in such regions between the spots may be removed with removal of the protective cover.
摘要翻译: 在衬底上形成有保护罩的阵列。 将保护盖图案化以产生到基板的开口阵列。 期望的材料通过开口沉积在基底上。 然后可以移除保护盖。 在一个实施方案中,保护性覆盖物是保形聚合物,例如二对二甲苯。 可以通过机械剥离除去。 该材料可以是诸如DNA的生物材料。 保护罩可以用于通过与盖仍然在位的杂交来防止斑间区域中的非特异性杂交。 在斑点之间的这些区域中发生的杂交可以通过去除保护盖而被去除。