-
1.发明授权Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis 失效嘧啶核苷酸前体用于治疗全身性炎症和炎症性肝炎公开(公告)号：US07709459B2
公开(公告)日：2010-05-04
申请号：US10421831
申请日：2003-04-24
CPC分类号： A61K31/7064 , A61K31/513 , A61K31/515 , A61K31/7068 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
摘要翻译： 公开了包括胞苷，尿苷和乳清酸的酰基衍生物和尿苷磷酸化酶抑制剂的嘧啶核苷酸前体及其在增强抗败血症或全身炎症中的用途。
-
公开(公告)号：US06060459A
公开(公告)日：2000-05-09
申请号：US465016
申请日：1995-06-05
申请人： Reid W. von Borstel , Michael K. Bamat , Bradley M. Hiltbrand , James C. Butler , Shyam Shirali
发明人： Reid W. von Borstel , Michael K. Bamat , Bradley M. Hiltbrand , James C. Butler , Shyam Shirali
IPC分类号： A61K31/70 , C07D473/00 , C07H19/16 , C07H19/167
CPC分类号： A61K31/70 , C07D473/00 , C07H19/16 , C07H19/167 , Y10S514/814
摘要： The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematopoiesis, and treating or preventing inflammatory diseases and bacterial infections by administering a compound or composition of the present invention to an animal.
摘要翻译： 本发明涉及某些羟基嘌呤核苷，这种羟基嘌呤核苷的同系物及其酰基衍生物，以及含有至少一种这些化合物的组合物。 本发明还涉及通过向动物施用本发明的化合物或组合物来治疗或预防造血障碍和修饰造血，以及治疗或预防炎性疾病和细菌感染的方法。
-
3.发明授权Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis 失效氧基嘌呤核苷及其同系物及其酰基衍生物，用于改善造血作用
公开(公告)号：US6054441A
公开(公告)日：2000-04-25
申请号：US463790
申请日：1995-06-05
申请人： Reid W. von Borstel , Michael K. Bamat , Bradley M. Hiltbrand , James C. Butler , Shyam Shirali
发明人： Reid W. von Borstel , Michael K. Bamat , Bradley M. Hiltbrand , James C. Butler , Shyam Shirali
IPC分类号： A61K31/70 , C07D473/00 , C07H19/16 , C07H19/167
CPC分类号： A61K31/70 , C07D473/00 , C07H19/16 , C07H19/167 , Y10S514/814
摘要： The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematopoiesis, and treating or preventing inflammatory diseases and bacterial infections by administering a compound or composition of the present invention to an animal.
摘要翻译： 本发明涉及某些羟基嘌呤核苷，这种羟基嘌呤核苷的同系物及其酰基衍生物，以及含有至少一种这些化合物的组合物。 本发明还涉及通过向动物施用本发明的化合物或组合物来治疗或预防造血障碍和修饰造血，以及治疗或预防炎性疾病和细菌感染的方法。
-
4.发明授权Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis 失效嘧啶核苷酸前体用于治疗全身性炎症和炎症性肝炎公开(公告)号：US06329350B1
公开(公告)日：2001-12-11
申请号：US08464939
申请日：1995-06-05
IPC分类号： C07H1906
CPC分类号： A61K31/7064 , A61K31/00 , A61K31/505 , A61K31/513 , A61K31/515 , A61K31/70 , A61K31/7068 , A61K31/7072 , A61K31/7088 , A61K31/715 , A61K45/06 , C07H19/06 , A61K2300/00
摘要： Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
摘要翻译： 公开了包括胞苷，尿苷和乳清酸的酰基衍生物和尿苷磷酸化酶抑制剂的嘧啶核苷酸前体及其在增强抗败血症或全身炎症中的用途。
-
5.发明授权Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis 失效Oxpurine核苷及其同系物及其酰基及其衍生物，用于改善造血作用公开(公告)号：US07307166B1
公开(公告)日：2007-12-11
申请号：US08463771
申请日：1995-06-05
申请人： Reid W. von Borstel , Michael K. Bamat , Bradley M. Hiltbrand , James C. Butler , Shyam Shirali
发明人： Reid W. von Borstel , Michael K. Bamat , Bradley M. Hiltbrand , James C. Butler , Shyam Shirali
IPC分类号： C07D473/30 , C07D473/18 , C07D473/06 , C07F9/6561 , A61K31/522
CPC分类号： A61K31/70 , C07D473/00 , C07H19/16 , C07H19/167 , Y10S514/814
摘要： The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematopoiesis, and treating or preventing inflammatory diseases and bacterial infections by administering a compound or composition of the present invention to an animal.
摘要翻译： 本发明涉及某些羟基嘌呤核苷，这种羟基嘌呤核苷的同系物及其酰基衍生物，以及含有至少一种这些化合物的组合物。 本发明还涉及通过向动物施用本发明的化合物或组合物来治疗或预防造血障碍和修饰造血，以及治疗或预防炎性疾病和细菌感染的方法。
-
6.发明授权Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis 失效用于治疗全身性炎症和炎性肝炎的酰化嘧啶核苷
公开(公告)号：US5691320A
公开(公告)日：1997-11-25
申请号：US465454
申请日：1995-06-05
IPC分类号： A61K31/00 , A61K31/505 , A61K31/513 , A61K31/515 , A61K31/70 , A61K31/7068 , A61K31/7072 , A61K31/715 , A61K45/06 , C07H19/06 , C07H19/067
CPC分类号： A61K31/7064 , A61K31/00 , A61K31/505 , A61K31/513 , A61K31/515 , A61K31/70 , A61K31/7068 , A61K31/7072 , A61K31/7088 , A61K31/715 , A61K45/06 , C07H19/06
摘要： Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
摘要翻译： 公开了包括胞苷，尿苷和乳清酸的酰基衍生物和尿苷磷酸化酶抑制剂的嘧啶核苷酸前体及其在增强抗败血症或全身炎症中的用途。
-
7.发明授权Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis 失效嘧啶核苷酸前体用于治疗全身性炎症和炎症性肝炎公开(公告)号：US07173017B1
公开(公告)日：2007-02-06
申请号：US08465455
申请日：1995-06-05
IPC分类号： A61K31/70
CPC分类号： A61K31/7064 , A61K31/00 , A61K31/505 , A61K31/513 , A61K31/515 , A61K31/70 , A61K31/7068 , A61K31/7072 , A61K31/7088 , A61K31/715 , A61K45/06 , C07H19/06 , A61K2300/00
摘要： Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
摘要翻译： 公开了包括胞苷，尿苷和乳清酸的酰基衍生物和尿苷磷酸化酶抑制剂的嘧啶核苷酸前体及其在增强抗败血症或全身炎症中的用途。
-
8.发明授权公开(公告)号：US06232298B1
公开(公告)日：2001-05-15
申请号：US08479519
申请日：1995-06-07
IPC分类号： A01N4304
CPC分类号： A61K31/7064 , A61K31/00 , A61K31/505 , A61K31/513 , A61K31/515 , A61K31/70 , A61K31/7068 , A61K31/7072 , A61K31/7088 , A61K31/715 , A61K45/06 , C07H19/06 , A61K2300/00
摘要： Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
-
9.发明授权Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides 失效化学治疗剂或抗病毒剂与酰化嘧啶核苷的组合物
公开(公告)号：US5736531A
公开(公告)日：1998-04-07
申请号：US176485
申请日：1993-12-30
IPC分类号： A61K31/513 , A61K31/515 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/067 , C07H19/073 , C07H19/09
CPC分类号： A61K31/70 , A61K31/513 , A61K31/515 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07H19/06 , C07H19/10
摘要： The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.
摘要翻译： 本发明公开了用于治疗和预防由于化学治疗剂和抗病毒剂引起的毒性的化合物，组合物和方法。 公开了非甲基化嘧啶核苷的酰化衍生物。 这些化合物能够减轻接受抗病毒或抗肿瘤化疗的动物对造血系统的损伤。
-
10.发明授权公开(公告)号：US06344447B1
公开(公告)日：2002-02-05
申请号：US09249790
申请日：1999-02-16
IPC分类号： A61K3170
摘要： The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.032 秒)
