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公开(公告)号:US09403909B2
公开(公告)日:2016-08-02
申请号:US13206736
申请日:2011-08-10
申请人: Reimi Kawaida , Toshiaki Ohtsuka , Toshinori Agatsuma , Philip Rodley , Sandra Miller , Ulrike Schubert
发明人: Reimi Kawaida , Toshiaki Ohtsuka , Toshinori Agatsuma , Philip Rodley , Sandra Miller , Ulrike Schubert
IPC分类号: A61K39/395 , C07K16/28 , A61K39/00
CPC分类号: C07K16/2863 , A61K39/39558 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/565 , G01N2333/9121
摘要: The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for MST1R, which plays an integral role in various disorders or conditions, such as cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the disclosure also can be used in the diagnostics field, as well as for further investigating the role of MST1R in the progression of disorders associated with tumors. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译: 本公开提供了重组抗原结合区和包含对MST1R特异性的这种抗原结合区的功能片段,其在各种疾病或病症例如癌症中起积体作用。 因此,这些抗体可用于治疗这些和其他病症和病症。 本公开的抗体也可用于诊断领域,以及用于进一步研究MST1R在与肿瘤相关的疾病进展中的作用。 本公开还提供了编码前述抗体的核酸序列,含有该抗体的载体,药物组合物和具有使用说明书的试剂盒。
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公开(公告)号:US20120034215A1
公开(公告)日:2012-02-09
申请号:US13206736
申请日:2011-08-10
申请人: Reimi Kawaida , Toshiaki Ohtsuka , Toshinori Agatsuma , Philip Rodley , Sandra Miller , Ulrike Schubert
发明人: Reimi Kawaida , Toshiaki Ohtsuka , Toshinori Agatsuma , Philip Rodley , Sandra Miller , Ulrike Schubert
IPC分类号: A61K39/395 , C12N15/13 , A61P35/00 , C12P21/00 , C12N5/10 , C12N1/21 , C12N5/071 , C07K16/28 , C12N15/63
CPC分类号: C07K16/2863 , A61K39/39558 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/565 , G01N2333/9121
摘要: The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for MST1R, which plays an integral role in various disorders or conditions, such as cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the disclosure also can be used in the diagnostics field, as well as for further investigating the role of MST1R in the progression of disorders associated with tumors. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译: 本公开提供了重组抗原结合区和包含对MST1R特异性的这种抗原结合区的功能片段,其在各种疾病或病症例如癌症中起积体作用。 因此,这些抗体可用于治疗这些和其他病症和病症。 本公开的抗体也可用于诊断领域,以及用于进一步研究MST1R在与肿瘤相关的疾病进展中的作用。 本公开还提供了编码前述抗体的核酸序列,含有该抗体的载体,药物组合物和具有使用说明书的试剂盒。
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