公开(公告)号：US20230353959A1

公开(公告)日：2023-11-02

申请号：US18208023

申请日：2023-06-09

Applicant: Relay Therapeutics, Inc. ,  D.E. Shaw Research, LLC

Inventor： Lucian V. DIPIETRO ,  Kelley C. SHORTSLEEVES ,  Thomas H. MCLEAN ,  Alexandre LARIVEE ,  Fabrizio GIORDANETTO

IPC: H04R25/00 ,  A61B5/00

CPC classification number: H04R25/554 ,  A61B5/0026 ,  A61B5/746 ,  H04R2225/55

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-α enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-α signaling with the compounds and compositions of the disclosure.

公开(公告)号：US20230192709A1

公开(公告)日：2023-06-22

申请号：US18162127

申请日：2023-01-31

Applicant: Relay Therapeutics, Inc. ,  D.E. Shaw Research, LLC

Inventor： Bakary-Barry TOURÉ ,  Heike SCHOENHERR ,  Fabrizio GIORDANETTO ,  Demetri T. MOUSTAKAS ,  Bradi M. DUDSON

IPC: C07D487/04 ,  C07D491/048 ,  C07D498/22 ,  C07D487/22 ,  C07D498/02 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D491/048 ,  C07D498/22 ,  C07D487/22 ,  C07D498/02 ,  C07D519/00

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of FGFR enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with FGFR signaling with the compounds and compositions of the disclosure.

公开(公告)号：US20220144840A1

公开(公告)日：2022-05-12

申请号：US17429115

申请日：2020-02-06

Applicant: D.E. Shaw Research, LLC

Inventor： Fabrizio GIORDANETTO ,  Cecily CAMPBELL-BEZAT ,  Albert PAN

IPC: C07D487/04 ,  C07D471/04

Abstract: A compound of Formula (I) or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

公开(公告)号：US20240368078A1

公开(公告)日：2024-11-07

申请号：US18553339

申请日：2022-03-29

Applicant: D.E. SHAW RESEARCH, LLC

Inventor： Fabrizio GIORDANETTO ,  Morten Østergaard JENSEN ,  Vishwanath JOGINI ,  Roger John SNOW

IPC: C07D207/09 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/53 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/12 ,  C07D413/06

Abstract: A compound of Formula I or a pharmaceutically-acceptable salt thereof, is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

公开(公告)号：US20230373952A1

公开(公告)日：2023-11-23

申请号：US18247521

申请日：2021-10-04

Applicant: D.E. Shaw Research, LLC

Inventor： Fabrizio GIORDANETTO ,  Morten Østergaard JENSEN ,  Vishwanath JOGINI ,  Roger John SNOW

IPC: C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D207/27 ,  C07D403/06 ,  C07D417/04 ,  C07D413/04 ,  C07D263/20 ,  C07D265/32 ,  C07D233/32

CPC classification number: C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D207/27 ,  C07D403/06 ,  C07D417/04 ,  C07D413/04 ,  C07D263/20 ,  C07D265/32 ,  C07D233/32

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is described, where the substituents are as defined herein. Pharmaceutical compositions including the same and method of using the same are also described.

公开(公告)号：US20200308165A1

公开(公告)日：2020-10-01

申请号：US16645379

申请日：2018-09-12

Applicant: D.E. Shaw Research, LLC

Inventor： Yibing SHAN ,  Venkat MYSORE ,  Fabrizio GIORDANETTO ,  Qi WANG

IPC: C07D417/14 ,  C07D401/14 ,  C07D401/04 ,  C07D403/04 ,  C07D413/14 ,  C07D403/14

Abstract: A compound of Formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

公开(公告)号：US20240391926A1

公开(公告)日：2024-11-28

申请号：US18564752

申请日：2022-05-27

Applicant: D.E. Shaw Research, LLC

Inventor： Fabrizio GIORDANETTO ,  Morten Østergaard JENSEN ,  Vishwanath JOGINI ,  Roger John SNOW

IPC: C07D487/10 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/497

Abstract: A compound of Formula (I) or a pharmaceutically-acceptable salt thereof, is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

公开(公告)号：US20240287058A1

公开(公告)日：2024-08-29

申请号：US17921580

申请日：2021-04-29

Applicant: Relay Therapeutics, Inc. ,  D. E. Shaw Research, LLC

Inventor： Alessandro BOEZIO ,  Lucian V. DIPIETRO ,  Cary Griffin FRIDRICH ,  Hakan GUNAYDIN ,  Ravi KURUKULASURIYA ,  André LESCARBEAU ,  Mary M. MADER ,  Thomas H. MCLEAN ,  Levi CharlesThomas PIERCE ,  Kevin David RAYNOR ,  Kelley C. SHORTSLEEVES ,  Yong TANG ,  Alexander M. TAYLOR ,  W. Patrick WALTERS ,  Hanmo ZHANG ,  Fabrizio GIORDANETTO ,  Yakov PECHERSKY ,  Qi WANG ,  Bren-Jordan ATIENZA ,  Megan BERTRAND-LAPERLE ,  Andrew J. BURNIE ,  Fei CHEN ,  Sampada CHITALE ,  Shorena GELOZIA ,  Jean-Benoit GIGUERE ,  Elodie LANDAGARAY ,  Alexandre LARIVEE ,  Thomas LEPITRE ,  Gaetan MAERTENS ,  Johanne OUTIN ,  Mohan PAL ,  Claudio STURINO ,  Kashif TANVEER ,  Rakesh THORAT ,  Naresh VEMULA ,  Elaine B. KRUEGER ,  Yue PAN ,  Michael Paul DENINNO ,  Yves BOUSQUET ,  Antoine JOBIN-DES LAURIERS ,  Jessica LEE ,  Tarek MOHAMED

IPC: C07D471/04 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/472 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/536 ,  A61K31/69 ,  C07D209/46 ,  C07D209/48 ,  C07D217/24 ,  C07D231/56 ,  C07D239/82 ,  C07D265/18 ,  C07D275/06 ,  C07D401/04 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D487/04 ,  C07D519/00 ,  C07F5/02

CPC classification number: C07D471/04 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4545 ,  A61K31/472 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/536 ,  A61K31/69 ,  C07D209/46 ,  C07D209/48 ,  C07D217/24 ,  C07D231/56 ,  C07D239/82 ,  C07D265/18 ,  C07D275/06 ,  C07D401/04 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D487/04 ,  C07D519/00 ,  C07F5/025

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-α enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-α signaling with the compounds and compositions of the disclosure.