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公开(公告)号：US10081788B2
公开(公告)日：2018-09-25
申请号：US15269409
申请日：2016-09-19
Applicant: Repligen Corporation
Inventor： Jerry Shevitz
CPC classification number: C12M29/18 , B01D61/14 , B01D61/58 , B01D63/02 , B01D2313/13 , B01D2313/243 , B01D2313/50 , C12M29/04 , C12M29/16 , C12M33/10
Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
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公开(公告)号：US09993751B2
公开(公告)日：2018-06-12
申请号：US14733417
申请日：2015-06-08
Applicant: Repligen Corporation
Inventor： Jerry Shevitz
CPC classification number: B01D29/68 , B01D29/111 , B01D29/114 , B01D29/13 , B01D29/66 , B01D35/153 , B01D35/26 , B01D35/30 , C12M47/02
Abstract: Improved screen filter modules, related compartmentalized filtration modules, and related filtration processes, suitable for filtering fluid to eliminate suspended particulate matter, such as living cells or microcarriers anchoring living cells, or to separate particulate matter based on size. The improvement is the presence of a barrier that channels redirected filtrate to the portion of the filter most susceptible to clogging by the particulate matter and induces flow patterns that act against clogging.
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Patent Agency Ranking
3.发明申请Device, System and Process for Modification or Concentration of Cell-Depleted Fluid 审中-公开用于改变或浓缩细胞消耗液体的装置，系统和方法公开(公告)号：US20170002305A1
公开(公告)日：2017-01-05
申请号：US15269409
申请日：2016-09-19
Applicant: Repligen Corporation
Inventor： Jerry Shevitz
CPC classification number: C12M29/18 , B01D61/14 , B01D61/58 , B01D63/02 , B01D2313/13 , B01D2313/243 , B01D2313/50 , C12M29/04 , C12M29/16 , C12M33/10
Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
Abstract translation: 一种产品浓度装置，其利用连接到中空纤维过滤元件的储存器，其中储存器可以用作从另一个过滤装置发出的滤液的容器，使得储存器中的产品可以根据需要进行储存，浓缩和/或进一步处理 。 封闭的反应器系统，每个至少三个室，在由选择性渗透屏障控制的室之间的流体流动，由交流流动隔膜泵控制。
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公开(公告)号：US20220098539A1
公开(公告)日：2022-03-31
申请号：US17547893
申请日：2021-12-10
Applicant: Repligen Corporation
Inventor： Jerry Shevitz
Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
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公开(公告)号：US20190127679A1
公开(公告)日：2019-05-02
申请号：US16140146
申请日：2018-09-24
Applicant: Repligen Corporation
Inventor： Jerry Shevitz
Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
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公开(公告)号：US11225637B2
公开(公告)日：2022-01-18
申请号：US16140146
申请日：2018-09-24
Applicant: Repligen Corporation
Inventor： Jerry Shevitz
Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
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公开(公告)号：US20150273368A1
公开(公告)日：2015-10-01
申请号：US14733417
申请日：2015-06-08
Applicant: Repligen Corporation
Inventor： Jerry Shevitz
CPC classification number: B01D29/68 , B01D29/111 , B01D29/114 , B01D29/13 , B01D29/66 , B01D35/153 , B01D35/26 , B01D35/30 , C12M47/02
Abstract: Improved screen filter modules, related compartmentalized filtration modules, and related filtration processes, suitable for filtering fluid to eliminate suspended particulate matter, such as living cells or microcarriers anchoring living cells, or to separate particulate matter based on size. The improvement is the presence of a barrier that channels redirected filtrate to the portion of the filter most susceptible to clogging by the particulate matter and induces flow patterns that act against clogging.
Abstract translation: 改进的筛网过滤器模块，相关的分区过滤模块和相关的过滤方法，适用于过滤流体以消除悬浮颗粒物质，例如锚定活细胞的活细胞或微载体，或基于尺寸分离颗粒物质。 改进是存在通道将滤液重新导向过滤器的部分，其最容易受到颗粒物质的堵塞并且引起阻止堵塞的流动模式。
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