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公开(公告)号：US11566007B2
公开(公告)日：2023-01-31
申请号：US17089035
申请日：2020-11-04
发明人： Elena S. Koltun , James Cregg , Adrian L. Gill , Andreas Buckl , Yang Liu
IPC分类号： C07D487/08 , A61K31/504 , A61K38/12 , A61P35/00 , C07D245/04
摘要： The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
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公开(公告)号：US20230303591A1
公开(公告)日：2023-09-28
申请号：US17938890
申请日：2022-10-07
发明人： Andreas Buckl , G. Leslie Burnett , James Cregg , Anne V. Edwards , Adrian L. Gill , John E. Knox , Elena S. Koltun , Yang Liu , Christopher Semko
IPC分类号： C07D519/00 , A61P35/00
CPC分类号： C07D519/00 , A61P35/00 , C07B2200/05
摘要： The invention features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
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公开(公告)号：US11739074B2
公开(公告)日：2023-08-29
申请号：US17088848
申请日：2020-11-04
发明人： James Aggen , G. Leslie Burnett , Jennifer Pitzen , Adrian L. Gill , Elena S. Koltun , James Cregg , Andreas Buckl , Anne V. Edwards , John E. Knox
IPC分类号： C07D487/04 , C07D487/10 , C07D513/14 , C07D401/14 , A61P35/00
CPC分类号： C07D401/14 , A61P35/00 , C07D487/04 , C07D487/10 , C07D513/14
摘要： The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers. Exemplary Ras inhibitors include compounds of Formula I:
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公开(公告)号：US20230234929A1
公开(公告)日：2023-07-27
申请号：US18161266
申请日：2023-01-30
发明人： Elena S. KOLTUN , James Cregg , Adrian L. Gill , James Aggen , G. Leslie Burnett , Jennifer Pitzen , Andreas Buckl , John E. Knox , Yang Liu
IPC分类号： C07D245/04 , A61P35/00
CPC分类号： C07D245/04 , A61P35/00
摘要： The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
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公开(公告)号：US20210139517A1
公开(公告)日：2021-05-13
申请号：US17090342
申请日：2020-11-05
发明人： Adrian L. Gill , Andreas Buckl , Elena S. Koltun , Naing Aay , Arlyn A. Tambo-ong , Severin Thompson , Micah James Gliedt , John E. Knox , James Cregg , Anne V. Edwards , Yang Liu , G. Leslie Burnett
IPC分类号： C07F9/6584 , C07D471/04 , C07D519/00
摘要： The present disclosure is directed to modulators of SOS1 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
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公开(公告)号：US20240139185A1
公开(公告)日：2024-05-02
申请号：US18184766
申请日：2023-03-16
发明人： Meizhong JIN , Nicholas Perl , Anna Kohlmann , Ning Yin , Jason T. Lowe , Jae Young Ahn , Mark Joseph Mulvihill , Elena S. Koltun , Adrian L. Gill
IPC分类号： A61K31/504 , A61K45/06 , C07D487/18 , C07D498/18 , C07D498/22
CPC分类号： A61K31/504 , A61K45/06 , C07D487/18 , C07D498/18 , C07D498/22
摘要： The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.
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公开(公告)号：US11608346B2
公开(公告)日：2023-03-21
申请号：US17088986
申请日：2020-11-04
发明人： Elena S. Koltun , James Cregg , Adrian L. Gill
IPC分类号： C07D498/18 , C07D401/14 , C07D498/22 , C07D513/22 , C07D519/00 , A61P35/00
摘要： The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
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公开(公告)号：US11952352B2
公开(公告)日：2024-04-09
申请号：US18161266
申请日：2023-01-30
发明人： Adrian L. Gill , James Cregg , Elena S. Koltun , Yang Liu
IPC分类号： C07D487/08 , A61K31/504 , A61P35/00 , C07D245/04
CPC分类号： C07D245/04 , A61P35/00
摘要： The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
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公开(公告)号：US20230365605A1
公开(公告)日：2023-11-16
申请号：US18045647
申请日：2022-10-11
发明人： Adrian L. Gill , Andreas Buckl , Elena S. Koltun , Naing Aay , Arlyn A. Tambo-ong , Severin Thompson , Micah James Gliedt , John E. Knox , James Cregg , Anne V. Edwards , Yang Liu , G. Leslie Burnett
IPC分类号： C07D519/00 , C07F9/6584 , C07D471/04
CPC分类号： C07F9/6584 , C07D471/04 , C07D519/00
摘要： The present disclosure is directed to modulators of SOS1 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
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公开(公告)号：US11690915B2
公开(公告)日：2023-07-04
申请号：US17476269
申请日：2021-09-15
发明人： Naing Aay , G. Leslie Burnett , James Cregg , Adrian L. Gill , John E. Knox , Elena S. Koltun , Yang Liu , Andreas Buckl , Bianca Jennifer Lee , David E. Wildes , Meghan A. Rice , Mallika Singh
IPC分类号： A61K45/06 , C07D417/14 , A61P35/00
CPC分类号： A61K45/06 , A61P35/00 , C07D417/14
摘要： The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
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