公开(公告)号：US07141559B2

公开(公告)日：2006-11-28

申请号：US10460491

申请日：2003-06-12

申请人： Richard D. Bishop ,  Russell Drew Cink ,  Bradley D. Gates ,  Lars T. Hagberg ,  Peer B. Jacobsen ,  Philip R. Kym ,  Chunqiu Lai ,  Marvin Robert Leanna ,  James T. Link ,  Steven J. Richards ,  Noah Tu ,  Tom W. von Geldern

发明人： Richard D. Bishop ,  Russell Drew Cink ,  Bradley D. Gates ,  Lars T. Hagberg ,  Peer B. Jacobsen ,  Philip R. Kym ,  Chunqiu Lai ,  Marvin Robert Leanna ,  James T. Link ,  Steven J. Richards ,  Noah Tu ,  Tom W. von Geldern

IPC分类号： A61K31/575 ,  C07J9/00

CPC分类号： C07J1/00 ,  Y10S514/866 ,  Y10S514/909

摘要： This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.

公开(公告)号：US07521439B2

公开(公告)日：2009-04-21

申请号：US11491337

申请日：2006-07-21

申请人： Richard D. Bishop ,  Russell Drew Cink ,  Bradley D. Gates ,  Lars T. Hagberg ,  Peer B. Jacobsen ,  Philip R. Kym ,  Chunqiu Lai ,  Marvin Robert Leanna ,  James T. Link ,  Steven J. Richards ,  Noah Tu ,  Tom W. von Geldern

发明人： Richard D. Bishop ,  Russell Drew Cink ,  Bradley D. Gates ,  Lars T. Hagberg ,  Peer B. Jacobsen ,  Philip R. Kym ,  Chunqiu Lai ,  Marvin Robert Leanna ,  James T. Link ,  Steven J. Richards ,  Noah Tu ,  Tom W. von Geldern

IPC分类号： A61K31/56

CPC分类号： C07J1/00 ,  Y10S514/866 ,  Y10S514/909

摘要： This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.

摘要翻译： 本发明涉及作为肝脏选择性糖皮质激素受体拮抗剂的新型化合物，制备这些化合物的方法，以及使用这些化合物来调节代谢的方法，特别是降低血清葡萄糖水平，胰岛素水平或脂质水平，和/或 减轻体重。