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    GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS
    1.
    发明申请
    GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS 有权
    GLUCAGON / GLP-1受体协同作用

    公开(公告)号：US20110257092A1

    公开(公告)日：2011-10-20

    申请号：US12999283

    申请日：2009-06-16

    申请人： Richard D. Dimarchi ,  David l. Smiley ,  Maria Dimarchi ,  Joseph Chabenne ,  Jonathan Day ,  James Patterson ,  Brian Ward

    发明人： Richard D. Dimarchi ,  David l. Smiley ,  Maria Dimarchi ,  Joseph Chabenne ,  Jonathan Day ,  James Patterson ,  Brian Ward

    IPC分类号： A61K38/26 ,  A61P3/04 ,  A61P3/10 ,  C07K14/605

    CPC分类号： C07K14/605

    摘要： Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).

    摘要翻译： 公开了相对于天然胰高血糖素在胰高血糖素受体上具有增强的效力的改良的胰高血糖素肽。 通过形成分子内桥或通过酰胺基取代末端羧酸对胰高血糖素肽进一步修饰产生显示胰高血糖素/ GLP-1受体共激动剂活性的肽。 通过聚乙二醇化，酰化，烷基化，羧基末端氨基酸的取代，C-末端截短或加入选自下组的羧基末端肽，可以进一步改善这些高效胰高血糖素类似物的溶解度和稳定性 由SEQ ID NO：26（GPSSGAPPPS），SEQ ID NO：27（KRNRNNIA）和SEQ ID NO：28（KRNR）组成。

    Glucagon/GLP-1 receptor co-agonists
    4.
    发明授权
    Glucagon/GLP-1 receptor co-agonists 有权
    胰高血糖素/ GLP-1受体共激动剂

    公开(公告)号：US08454971B2

    公开(公告)日：2013-06-04

    申请号：US12527140

    申请日：2008-02-13

    申请人： Jonathan Day ,  James Patterson ,  Joseph Chabenne ,  Maria Dimarchi ,  David L. Smiley ,  Richard D. Dimarchi

    发明人： Jonathan Day ,  James Patterson ,  Joseph Chabenne ,  Maria Dimarchi ,  David L. Smiley ,  Richard D. Dimarchi

    IPC分类号： A61K38/26 ,  C07K14/605

    CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K38/26 ,  A61K47/60 ,  C07K16/00 ,  C07K2317/52 ,  C07K2319/30

    摘要： Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming lactam bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, substitution of carboxy terminal amino acids, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (K-RNRNNIA) and SEQ ID NO: 28 (KRNR).

    摘要翻译： 公开了相对于天然胰高血糖素在胰高血糖素受体上具有增强的效力的改良的胰高血糖素肽。 通过形成内酰胺桥或用酰胺基取代末端羧酸对胰高血糖素肽进一步修饰产生显示胰高血糖素/ GLP-1受体共激动剂活性的肽。 这些高效胰高血糖素类似物的溶解度和稳定性可以通过聚乙二醇化，多肽羧基末端氨基酸的取代或加入选自SEQ ID NO：26（GPSSGAPPPS ），SEQ ID NO：27（K-RNRNNIA）和SEQ ID NO：28（KRNR）。

    GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS
    5.
    发明申请
    GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS 有权
    GLUCAGON / GLP-1受体协同作用

    公开(公告)号：US20100190701A1

    公开(公告)日：2010-07-29

    申请号：US12527140

    申请日：2008-02-13

    申请人： Jonathan Day ,  James Patterson ,  Joseph Chabenne ,  Maria Dimarchi ,  David Smiely ,  Richard D. Dimarchi

    发明人： Jonathan Day ,  James Patterson ,  Joseph Chabenne ,  Maria Dimarchi ,  David Smiely ,  Richard D. Dimarchi

    IPC分类号： A61K38/26 ,  C07K14/605 ,  A61P3/10 ,  A61P3/04

    CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K38/26 ,  A61K47/60 ,  C07K16/00 ,  C07K2317/52 ,  C07K2319/30

    摘要： Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming lactam bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, substitution of carboxy terminal amino acids, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (K-RNRNNIA) and SEQ ID NO: 28 (KRNR).

    摘要翻译： 公开了相对于天然胰高血糖素在胰高血糖素受体上具有增强的效力的改良的胰高血糖素肽。 通过形成内酰胺桥或用酰胺基取代末端羧酸对胰高血糖素肽进一步修饰产生显示胰高血糖素/ GLP-1受体共激动剂活性的肽。 这些高效胰高血糖素类似物的溶解度和稳定性可以通过聚乙二醇化，多肽羧基末端氨基酸的取代或加入选自SEQ ID NO：26（GPSSGAPPPS ），SEQ ID NO：27（K-RNRNNIA）和SEQ ID NO：28（KRNR）。

    Anti-torqueing dynamic arresting mechanism
    7.
    发明授权
    Anti-torqueing dynamic arresting mechanism 有权

    公开(公告)号：US09833891B2

    公开(公告)日：2017-12-05

    申请号：US14628448

    申请日：2015-02-23

    申请人： James Patterson

    发明人： James Patterson

    IPC分类号： B25F5/00 ,  H02H7/085

    CPC分类号： B25F5/001 ,  H02H7/0856

    摘要： A dynamic arresting mechanism for preventing injury from the torqueing of a rotating tool body. The mechanism including an inertia switch to automatically detect the rotation of the tool body and selectively initiate a dynamic arresting mechanism sequence configured to arrest the motor. The mechanism further including a first relay in communication with the inertia switch, an arresting mechanism configured to brake the rotation of the motor, and a delay mechanism configured to cut off power to the arresting mechanism and motor after a predetermined amount of time has elapsed. The mechanism is reset upon release of the trigger used to operate the rotating tool.

    Electronic book contextual menu systems and methods
    9.
    发明授权
    Electronic book contextual menu systems and methods 有权
    电子书上下文菜单系统和方法

    公开(公告)号：US08543941B2

    公开(公告)日：2013-09-24

    申请号：US13182809

    申请日：2011-07-14

    申请人： James Patterson ,  Nathan Moody ,  Scott Dougall

    发明人： James Patterson ,  Nathan Moody ,  Scott Dougall

    IPC分类号： G06F17/25 ,  G06F17/26

    CPC分类号： G06F17/241 ,  G06F3/0482 ,  G06F3/0483 ,  G06F3/04842 ,  G06F3/04883 ,  G06F17/2235 ,  G06Q30/0621 ,  G06T3/60

    摘要： An electronic book system provides interfaces particularly suited to students' use of textbooks. A finger press on a touch screen produces a contextual menu with user choices that relate to where the finger was pressed or what the user was recently doing with the book. A student provisionally navigates through a book by a specific gesture which, when it stops, returns the user to the previous position in the book. Annotations are displayed and hidden using specific gestures and through selective movement of the reader as sensed by its accelerometer.

    摘要翻译： 电子书系统提供特别适合学生使用教科书的界面。 触摸屏上的手指按压产生与用户选择有关的上下文菜单，这些选项涉及手指按压的位置或用户最近在使用该书的方式。 学生通过特定的手势暂时浏览书籍，当它停止时，将用户返回到书中的前一位置。 使用特定手势并通过其加速度计所感测到的读取器的选择性移动来显示和隐藏注释。

    Systems and Methods for Remote Collaborative Studying Using Electronic Books
    10.
    发明申请
    Systems and Methods for Remote Collaborative Studying Using Electronic Books 有权
    使用电子书进行远程协作学习的系统与方法

    公开(公告)号：US20120221937A1

    公开(公告)日：2012-08-30

    申请号：US13182797

    申请日：2011-07-14

    申请人： James Patterson ,  Nathan Moody ,  Scott Dougall

    发明人： James Patterson ,  Nathan Moody ,  Scott Dougall

    IPC分类号： G06F3/01 ,  G06F17/00

    CPC分类号： G06F17/241 ,  G06F3/0482 ,  G06F3/0483 ,  G06F3/04842 ,  G06F3/04883 ,  G06F17/2235 ,  G06Q30/0621 ,  G06T3/60

    摘要： An electronic book system provides interfaces particularly suited to students' use of textbooks. A finger press on a touch screen produces a contextual menu with user choices that relate to where the finger was pressed or what the user was recently doing with the book. A student provisionally navigates through a book by a specific gesture which, when it stops, returns the user to the previous position in the book. Annotations are displayed and hidden using specific gestures and through selective movement of the reader as sensed by its accelerometer.

    摘要翻译： 电子书系统提供特别适合学生使用教科书的界面。 触摸屏上的手指按压产生与用户选择有关的上下文菜单，这些选项涉及手指按压的位置或用户最近在使用该书的方式。 学生通过特定的手势暂时浏览书籍，当它停止时，将用户返回到书中的前一位置。 使用特定手势并通过其加速度计所感测到的读取器的选择性移动来显示和隐藏注释。