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42 条记录 (耗时 0.045 秒)

    GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS
    1.
    发明申请
    GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS 有权
    GLUCAGON / GLP-1受体协同作用

    公开(公告)号：US20110257092A1

    公开(公告)日：2011-10-20

    申请号：US12999283

    申请日：2009-06-16

    申请人： Richard D. Dimarchi ,  David l. Smiley ,  Maria Dimarchi ,  Joseph Chabenne ,  Jonathan Day ,  James Patterson ,  Brian Ward

    发明人： Richard D. Dimarchi ,  David l. Smiley ,  Maria Dimarchi ,  Joseph Chabenne ,  Jonathan Day ,  James Patterson ,  Brian Ward

    IPC分类号： A61K38/26 ,  A61P3/04 ,  A61P3/10 ,  C07K14/605

    CPC分类号： C07K14/605

    摘要： Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).

    摘要翻译： 公开了相对于天然胰高血糖素在胰高血糖素受体上具有增强的效力的改良的胰高血糖素肽。 通过形成分子内桥或通过酰胺基取代末端羧酸对胰高血糖素肽进一步修饰产生显示胰高血糖素/ GLP-1受体共激动剂活性的肽。 通过聚乙二醇化，酰化，烷基化，羧基末端氨基酸的取代，C-末端截短或加入选自下组的羧基末端肽，可以进一步改善这些高效胰高血糖素类似物的溶解度和稳定性 由SEQ ID NO：26（GPSSGAPPPS），SEQ ID NO：27（KRNRNNIA）和SEQ ID NO：28（KRNR）组成。

    Processes for directionally ligating double stranded nucleic acids
    7.
    发明授权
    Processes for directionally ligating double stranded nucleic acids 失效
    用于定向连接双链核酸的方法

    公开(公告)号：US07504238B2

    公开(公告)日：2009-03-17

    申请号：US11119869

    申请日：2005-05-02

    申请人： Brian Ward ,  Chuan Li ,  Keming Song ,  Kristen E. Bettinger ,  Stephanie Uder

    发明人： Brian Ward ,  Chuan Li ,  Keming Song ,  Kristen E. Bettinger ,  Stephanie Uder

    IPC分类号： C12P19/34

    CPC分类号： C12N15/66 ,  C12Q1/6846 ,  C12Q2525/125 ,  C12Q2521/319

    摘要： Amplification mixtures, kits, amplicons, kits and processes are provided for amplifying a nucleic acid. In particular, provided are processes which utilize an amplification mixture comprising a polymerase, a deoxynucleotidetriphosphate (dNTP) mixture which contains modified dNTPs, a first primer and a second primer. Further provided are dNTP mixtures which contain modified dNTPs for at least two of the four nucleotide triphosphates, which when incorporated into a polynucelotide, impart resistance to enzymatic degradation by an exonuclease at the sites of incorporation of the modified dNTPs. Also provided are the amplicons and vectors which incorporate the modified nucleotides.

    摘要翻译： 提供扩增混合物，试剂盒，扩增子，试剂盒和方法用于扩增核酸。 特别地，提供了利用包含聚合酶，含有修饰的dNTP的脱氧核苷三磷酸（dNTP）混合物，第一引物和第二引物的扩增混合物的方法。 还提供了dNTP混合物，其含有用于四种核苷酸三磷酸中的至少两种的修饰的dNTP，当掺入多聚苷中时，其在掺入修饰的dNTP的位点赋予外切核酸酶对酶降解的抗性。 还提供了掺入修饰的核苷酸的扩增子和载体。