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![Amide Derivatives of 7-Amino-3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents](/abs-image/US/2008/02/07/US20080032970A1/abs.jpg.150x150.jpg)
1.发明申请Amide Derivatives of 7-Amino-3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents 失效7-氨基-3-苯基 - 二氢嘧啶并[4,5-D]嘧啶酮的酰胺衍生物及其作为药剂的制造和用途公开(公告)号：US20080032970A1
公开(公告)日：2008-02-07
申请号：US11660197
申请日：2005-08-30
申请人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolgfang Schaefer , Stefan Scheiblich , Manfred Schwaiger
发明人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolgfang Schaefer , Stefan Scheiblich , Manfred Schwaiger
IPC分类号： A61K31/519 , A61K31/496 , A61K31/535 , A61P43/00 , C07D239/70 , C07D413/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
摘要翻译： 本发明涉及7-氨基-3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新型酰胺衍生物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性的用途 代理商 本发明的衍生物是通式（I）的新化合物。
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![Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents](/abs-image/US/2010/02/02/US07655651B2/abs.jpg.150x150.jpg)
2.发明授权Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents 失效3-苯基 - 二氢嘧啶并[4,5-d]嘧啶酮的酰胺衍生物，其制造和用作药剂公开(公告)号：US07655651B2
公开(公告)日：2010-02-02
申请号：US11660198
申请日：2005-08-30
申请人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
发明人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5355 , C07D239/38 , A61P29/00 , A61P35/00 , A61P19/08 , A61P25/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
摘要翻译： 本发明涉及3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新型酰胺衍生物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性剂的用途。 本发明的衍生物是通式（I）的新化合物。
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3.发明申请Azabenzimidazole Derivatives, Their Manufacture and Use as Anti-Cancer Agents 审中-公开氮杂苯并咪唑衍生物，其制造和用作抗癌剂公开(公告)号：US20090227578A1
公开(公告)日：2009-09-10
申请号：US11988813
申请日：2006-07-28
申请人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
发明人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式I化合物，其药学上可接受的盐，对映异构体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述 控制或预防疾病如癌症的化合物。
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![Amide derivatives of 7-amino-3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents](/abs-image/US/2009/02/24/US07494993B2/abs.jpg.150x150.jpg)
4.发明授权Amide derivatives of 7-amino-3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents 失效7-氨基-3-苯基 - 二氢嘧啶并[4,5-d]嘧啶酮的酰胺衍生物，其制造和用作药剂公开(公告)号：US07494993B2
公开(公告)日：2009-02-24
申请号：US11660197
申请日：2005-08-30
申请人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
发明人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
IPC分类号： C07D413/14 , C07D487/04 , A61K31/497 , A61K31/519 , A61K31/5355
CPC分类号： C07D487/04
摘要： The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
摘要翻译： 本发明涉及7-氨基-3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新型酰胺衍生物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性的用途 代理商 本发明的衍生物是通式（I）的新化合物。
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![Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents](/abs-image/US/2007/10/04/US20070232611A1/abs.jpg.150x150.jpg)
5.发明申请Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents 失效3-苯基 - 二氢嘧啶并[4,5-D]嘧啶酮的酰胺衍生物及其作为药剂的制造和用途公开(公告)号：US20070232611A1
公开(公告)日：2007-10-04
申请号：US11660198
申请日：2005-08-30
申请人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
发明人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
摘要翻译： 本发明涉及3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新型酰胺衍生物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性剂的用途。 本发明的衍生物是通式（I）的新化合物。
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公开(公告)号：US07393936B2
公开(公告)日：2008-07-01
申请号：US11000867
申请日：2004-12-01
CPC分类号： C12N9/1205
摘要： A method for the recombinant production and purification of a protein kinase selected from the group consisting of tyrosine protein kinases and serine/threonine kinases by expressing a nucleic acid encoding said kinase in a microbial host cell, forming inclusion bodies containing said kinase, isolating, solubilizing, naturing, and purifying said kinase wherein said purification is performed by hydrophobic interaction with an hydrophobic adsorbent under conditions whereby at least 70% of said protein kinase are not bound to said adsorbent and the protein kinase not bound to said adsorbent is recovered.
摘要翻译： 一种通过在微生物宿主细胞中表达编码所述激酶的核酸，重组产生和纯化选自酪氨酸蛋白激酶和丝氨酸/苏氨酸激酶的方法，形成含有所述激酶的包涵体，分离，增溶 ，变性和纯化所述激酶，其中所述纯化通过与疏水性吸附剂的疏水相互作用进行，其中至少70％的所述蛋白激酶不与所述吸附剂结合，并且不结合所述吸附剂的蛋白激酶被回收。
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公开(公告)号：US20050282250A1
公开(公告)日：2005-12-22
申请号：US11000867
申请日：2004-12-01
CPC分类号： C12N9/1205
摘要： A method for the recombinant production and purification of a protein kinase selected from the group consisting of tyrosine protein kinases and serine/threonine kinases by expressing a nucleic acid encoding said kinase in a microbial host cell, forming inclusion bodies containing said kinase, isolating, solubilizing, naturing, and purifying said kinase wherein said purification is performed by hydrophobic interaction with an hydrophobic adsorbent under conditions whereby at least 70% of said protein kinase are not bound to said adsorbent and the protein kinase not bound to said adsorbent is recovered.
摘要翻译： 一种通过在微生物宿主细胞中表达编码所述激酶的核酸，重组产生和纯化选自酪氨酸蛋白激酶和丝氨酸/苏氨酸激酶的方法，形成含有所述激酶的包涵体，分离，增溶 ，变性和纯化所述激酶，其中所述纯化通过与疏水性吸附剂的疏水相互作用进行，其中至少70％的所述蛋白激酶不与所述吸附剂结合，并且不结合所述吸附剂的蛋白激酶被回收。
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公开(公告)号：US20060089359A1
公开(公告)日：2006-04-27
申请号：US11233311
申请日：2005-09-23
申请人： Edward Boyd , Frederick Brookfield , Guy Georges , Bernhard Goller , Sabine Huensch , Petra Rueger , Matthias Rueth , Stefan Scheiblich , Christine Schuell , Wolfgang von der Saal , Justin Warne , Stefan Weigand
发明人： Edward Boyd , Frederick Brookfield , Guy Georges , Bernhard Goller , Sabine Huensch , Petra Rueger , Matthias Rueth , Stefan Scheiblich , Christine Schuell , Wolfgang von der Saal , Justin Warne , Stefan Weigand
IPC分类号： A61K31/502 , C07D403/02
CPC分类号： C07D403/12
摘要： Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.
摘要翻译： 公开了式I化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体。 还公开了制备上述化合物的方法，含有它们的药物组合物，以及上述化合物在治疗，控制或预防诸如癌症等疾病中的用途。
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公开(公告)号：US07226923B2
公开(公告)日：2007-06-05
申请号：US11233311
申请日：2005-09-23
申请人： Edward Boyd , Frederick Brookfield , Guy Georges , Bernhard Goller , Sabine Huensch , Petra Rueger , Matthias Rueth , Stefan Scheiblich , Christine Schuell , Wolfgang von der Saal , Justin Warne , Stefan Weigand
发明人： Edward Boyd , Frederick Brookfield , Guy Georges , Bernhard Goller , Sabine Huensch , Petra Rueger , Matthias Rueth , Stefan Scheiblich , Christine Schuell , Wolfgang von der Saal , Justin Warne , Stefan Weigand
IPC分类号： C07D403/12 , C07D403/14 , A61K31/502
CPC分类号： C07D403/12
摘要： Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.
摘要翻译： 公开了式I化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体。 还公开了制备上述化合物的方法，含有它们的药物组合物，以及上述化合物在治疗，控制或预防诸如癌症等疾病中的用途。
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公开(公告)号：US06627439B2
公开(公告)日：2003-09-30
申请号：US09886683
申请日：2001-06-21
申请人： Thorsten Hoevel , Stefan Koch , Manfred Kubbies , Olaf Mundigl , Petra Rueger
发明人： Thorsten Hoevel , Stefan Koch , Manfred Kubbies , Olaf Mundigl , Petra Rueger
IPC分类号： C12N516
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/28 , C07K2317/34 , C12N2799/026 , C12N2799/027
摘要： Antibody binding to the SEMP1 antigen and characterized in that said antibody binds to SEMP1 in a manner equivalent to an antibody selected from the group of antibodies DSM ACC2458, DSM ACC2459, DSM ACC2461, and DSM ACC2463 is useful for cancer diagnosis and therapy.
摘要翻译： 抗体与SEMP1抗原结合，其特征在于所述抗体以与抗体DSM ACC2458，DSM ACC2459，DSM ACC2461和DSM ACC2463的抗体相当的方式结合SEMP1可用于癌症诊断和治疗。
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