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    RECOMBINANT ADENOVIRAL VECTORS AND METHODS OF USE
    1.
    发明申请
    RECOMBINANT ADENOVIRAL VECTORS AND METHODS OF USE 审中-公开
    重组腺病毒载体及其使用方法

    公开(公告)号：US20070253932A1

    公开(公告)日：2007-11-01

    申请号：US11684548

    申请日：2007-03-09

    申请人： Richard Gregory ,  Ken Wills ,  Daniel Maneval

    发明人： Richard Gregory ,  Ken Wills ,  Daniel Maneval

    IPC分类号： A61K48/00

    CPC分类号： C12N15/86 ,  A61K35/761 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  C07K14/005 ,  C07K14/4746 ,  C12N7/00 ,  C12N2710/10321 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85 ,  A61K2300/00

    摘要： This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also are included within the scope of this invention. Thus, for example, the adenoviral vector of this invention can contain a foreign gene for the expression of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suicide gene thymidine kinase. (The latter must be used in conjunction with a thymidine kinase metabolite in order to be effective).

    摘要翻译： 本发明提供一种重组腺病毒表达载体，其特征在于部分或完全缺失腺病毒蛋白IX DNA并具有编码外来蛋白或其功能片段或突变体的基因。 转化的宿主细胞和生产重组蛋白和基因治疗的方法也包括在本发明的范围内。 因此，例如，本发明的腺病毒载体可以含有外源基因，用于表达有效调节细胞周期的蛋白质，如p53，Rb或mitosin，或诱导细胞死亡，如条件性自杀基因 胸苷激酶。 （后者必须与胸苷激酶代谢物结合使用才能有效）。

    Adenoviral vectors having a protein IX deletion
    5.
    发明申请
    Adenoviral vectors having a protein IX deletion 审中-公开

    公开(公告)号：US20070259429A9

    公开(公告)日：2007-11-08

    申请号：US09860211

    申请日：2001-05-18

    申请人： Richard Gregory ,  Ken Wills ,  Daniel Maneval

    发明人： Richard Gregory ,  Ken Wills ,  Daniel Maneval

    IPC分类号： C12N15/861 ,  C12N7/01

    CPC分类号： C07K14/4746 ,  A61K38/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85

    摘要： This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also are included within the scope of this invention. Thus, for example, the adenoviral vector of this invention can contain a foreign gene for the expression of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suicide gene thymidine kinase. (The latter must be used in conjunction with a thymidine kinase metabolite in order to be effective).

    Adenoviral vectors having a protein IX deletion
    6.
    发明申请
    Adenoviral vectors having a protein IX deletion 审中-公开
    具有蛋白质IX缺失的腺病毒载体

    公开(公告)号：US20070128166A1

    公开(公告)日：2007-06-07

    申请号：US11585742

    申请日：2006-10-23

    申请人： Richard Gregory ,  Ken Wills ,  Daniel Maneval

    发明人： Richard Gregory ,  Ken Wills ,  Daniel Maneval

    IPC分类号： A61K48/00 ,  C12N15/861

    CPC分类号： C12N15/86 ,  A61K35/761 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  C07K14/005 ,  C07K14/4746 ,  C12N7/00 ,  C12N2710/10321 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85 ,  A61K2300/00

    摘要： This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also are included within the scope of this invention. Thus, for example, the adenoviral vector of this invention can contain a foreign gene for the expression of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suicide gene thymidine kinase. (The latter must be used in conjunction with a thymidine kinase metabolite in order to be effective).

    摘要翻译： 本发明提供一种重组腺病毒表达载体，其特征在于部分或完全缺失腺病毒蛋白IX DNA并具有编码外来蛋白或其功能片段或突变体的基因。 转化的宿主细胞和生产重组蛋白和基因治疗的方法也包括在本发明的范围内。 因此，例如，本发明的腺病毒载体可以含有外源基因，用于表达有效调节细胞周期的蛋白质，如p53，Rb或mitosin，或诱导细胞死亡，如条件性自杀基因 胸苷激酶。 （后者必须与胸苷激酶代谢物结合使用才能有效）。

    Recombinant adenoviral vectors and methods of use
    9.
    发明申请
    Recombinant adenoviral vectors and methods of use 审中-公开
    重组腺病毒载体及其使用方法

    公开(公告)号：US20060140910A1

    公开(公告)日：2006-06-29

    申请号：US11319873

    申请日：2005-12-27

    申请人： Richard Gregory ,  Ken Wills ,  Daniel Maneval

    发明人： Richard Gregory ,  Ken Wills ,  Daniel Maneval

    IPC分类号： A61K48/00 ,  C12N15/861 ,  C12N7/00

    CPC分类号： C12N15/86 ,  A61K35/761 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  C07K14/005 ,  C07K14/4746 ,  C12N7/00 ,  C12N2710/10321 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85 ,  A61K2300/00

    摘要： This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also are included within the scope of this invention. Thus, for example, the adenoviral vector of this invention can contain a foreign gene for the expression of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suicide gene thymidine kinase. (The latter must be used in conjunction with a thymidine kinase metabolite in order to be effective).

    摘要翻译： 本发明提供一种重组腺病毒表达载体，其特征在于部分或完全缺失腺病毒蛋白IX DNA并具有编码外来蛋白或其功能片段或突变体的基因。 转化的宿主细胞和生产重组蛋白和基因治疗的方法也包括在本发明的范围内。 因此，例如，本发明的腺病毒载体可以含有外源基因，用于表达有效调节细胞周期的蛋白质，如p53，Rb或mitosin，或诱导细胞死亡，如条件性自杀基因 胸苷激酶。 （后者必须与胸苷激酶代谢物结合使用才能有效）。