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1.发明授权Use of CD40 ligand, a cytokine that binds CD40, to stimulate hybridoma cells 失效使用CD40配体，一种结合CD40的细胞因子来刺激杂交瘤细胞公开(公告)号：US06391637B1
公开(公告)日：2002-05-21
申请号：US08770981
申请日：1996-12-19
申请人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson
发明人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson
IPC分类号： C12N512
CPC分类号： C07K14/70575 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C07K2319/74 , C07K2319/75 , C12N15/62 , Y10S514/885
摘要： There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor. Also disclosed are methods of simulating hybridoma cells to increase monoclonal antibody production by administering a CD40 ligand polypeptide that stimulates B cell proliferation.
摘要翻译： 公开了可用于提供CD40-L多肽的多肽（CD40-L）和DNA序列，载体和转化的宿主细胞。 更具体地，本发明提供了结合CD40受体细胞外结合区的分离的人和鼠CD40-L多肽。 还公开了通过施用刺激B细胞增殖的CD40配体多肽来模拟杂交瘤细胞以增加单克隆抗体产生的方法。
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2.发明授权Methods of inhibiting CD40L binding to CD40 with soluble monomeric CD40L 失效用可溶性单体CD40L抑制CD40L与CD40结合的方法公开(公告)号：US06264951B1
公开(公告)日：2001-07-24
申请号：US08769819
申请日：1996-12-19
申请人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson
发明人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson
IPC分类号： A61K3817
CPC分类号： C12N15/62 , A61K38/00 , C07K14/70575 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C07K2319/74 , C07K2319/75 , Y10S514/885
摘要： There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor. Also disclosed are methods of inhibiting undesirable immune responses, preventing T cell interaction with B cells by blocking CD40L binding to CD40 sites on B cells and other target cells.
摘要翻译： 公开了可用于提供CD40-L多肽的多肽（CD40-L）和DNA序列，载体和转化的宿主细胞。 更具体地，本发明提供了结合CD40受体细胞外结合区的分离的人和鼠CD40-L多肽。 还公开了抑制不需要的免疫应答的方法，通过阻断CD40L结合到B细胞和其它靶细胞上的CD40位点来预防T细胞与B细胞的相互作用。
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3.发明授权Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same 失效重组可溶性CD40配体多肽和含有其的药物组合物
公开(公告)号：US5962406A
公开(公告)日：1999-10-05
申请号：US484624
申请日：1995-06-07
申请人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson , Arvia E. Morris , Jeffrey T. McGrew
发明人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson , Arvia E. Morris , Jeffrey T. McGrew
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C12N15/62 , A61K38/18 , C07K14/435
CPC分类号： C12N15/62 , C07K14/70575 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C07K2319/74 , C07K2319/75 , Y10S514/885
摘要： There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.
摘要翻译： 公开了可用于提供CD40-L多肽的多肽（CD40-L）和DNA序列，载体和转化的宿主细胞。 更具体地，本发明提供了结合CD40受体细胞外结合区的分离的人和鼠CD40-L多肽。
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公开(公告)号：US5981724A
公开(公告)日：1999-11-09
申请号：US477733
申请日：1995-06-07
申请人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson , Arvia E. Morris , Jeffrey T. McGrew
发明人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson , Arvia E. Morris , Jeffrey T. McGrew
CPC分类号： C07K14/70575 , C12N15/62 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C07K2319/74 , C07K2319/75 , Y10S514/885
摘要： There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.
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公开(公告)号：US06410711B1
公开(公告)日：2002-06-25
申请号：US09399106
申请日：1999-09-20
申请人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson , Arvia E. Morris , Jeffrey T. McGrew
发明人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson , Arvia E. Morris , Jeffrey T. McGrew
IPC分类号： C12N1519
CPC分类号： C07K14/70575 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C07K2319/74 , C07K2319/75 , C12N15/62 , Y10S514/885
摘要： There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.
摘要翻译： 公开了可用于提供CD40-L多肽的多肽（CD40-L）和DNA序列，载体和转化的宿主细胞。 更具体地，本发明提供了结合CD40受体细胞外结合区的分离的人和鼠CD40-L多肽。
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公开(公告)号：US06290972B1
公开(公告)日：2001-09-18
申请号：US08770974
申请日：1996-12-19
申请人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson
发明人： Richard J. Armitage , William C. Fanslow , Melanie K. Spriggs , Subhashini Srinivasan , Marylou G. Gibson
IPC分类号： A61K3817
CPC分类号： C07K14/70575 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C07K2319/74 , C07K2319/75 , C12N15/62 , Y10S514/885
摘要： There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.
摘要翻译： 公开了可用于提供CD40-L多肽的多肽（CD40-L）和DNA序列，载体和转化的宿主细胞。 更具体地，本发明提供了结合CD40受体细胞外结合区的分离的人和鼠CD40-L多肽。
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公开(公告)号：US6087329A
公开(公告)日：2000-07-11
申请号：US088913
申请日：1998-06-02
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C12N15/62 , A61K38/17 , A61K38/19 , C07K14/435 , C07K14/52
CPC分类号： C12N15/62 , C07K14/70575 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C07K2319/74 , C07K2319/75 , Y10S514/885
摘要： There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.
摘要翻译： 公开了可用于提供CD40-L多肽的多肽（CD40-L）和DNA序列，载体和转化的宿主细胞。 更具体地，本发明提供了结合CD40受体细胞外结合区的分离的人和鼠CD40-L多肽。
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公开(公告)号：US07405270B2
公开(公告)日：2008-07-29
申请号：US10200242
申请日：2002-07-19
IPC分类号： C07K14/435
CPC分类号： C12N15/62 , A61K38/00 , C07K14/70575 , C07K16/2875 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C07K2319/74 , C07K2319/75
摘要： There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor and lack native-pattern glycosylation.
摘要翻译： 公开了可用于提供CD40-L多肽的多肽（CD40-L）和DNA序列，载体和转化的宿主细胞。 更具体地，本发明提供了分离的人和鼠CD40-L多肽，其结合CD40受体的胞外结合区并且缺乏天然模式糖基化。
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公开(公告)号：US6106832A
公开(公告)日：2000-08-22
申请号：US589771
申请日：1996-01-22
IPC分类号： A61K35/12 , A61K38/00 , A61K39/395 , A61K48/00 , C07K14/705 , C07K19/00 , C12N5/10 , C12N15/85 , C12Q1/68 , A61K38/19
CPC分类号： A01K67/0276 , C07K14/70575 , C07K19/00 , C12N15/8509 , C12Q1/6883 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0381 , A61K38/00 , A61K48/00 , C07K2319/00 , C07K2319/30 , C12Q2600/156 , C12Q2600/158 , Y10S514/885
摘要： There is disclosed a method of detecting a mutation in a CD40 ligand gene, comprising isolating nucleic acid from an individual, selectively amplifying nucleic acid derived from the CD40 ligand gene, and analyzing the amplified nucleic acid to determine if there is a mutation (or mutations) in the CD40 ligand gene. The ability of a CD40 ligand protein expressed from the gene may be determined. Methods of treating individuals exhibiting a defective CD40 ligand gene (i.e., X-linked hyper IgM patients and certain individuals afflicted with combined variable immunodeficiency) are also disclosed. Also disclosed are non-human animals that lack functional CD40 ligand as a result of gene targeting technology.
摘要翻译： 公开了一种检测CD40配体基因突变的方法，包括分离来自个体的核酸，选择性扩增衍生自CD40配体基因的核酸，并分析扩增的核酸以确定是否存在突变（或突变 ）在CD40配体基因中。 可以测定从该基因表达的CD40配体蛋白的能力。 还公开了治疗表现出有缺陷的CD40配体基因（即，X连锁的超IgM患者和某些患有组合的可变免疫缺陷的个体）的个体的方法。 还公开了作为基因靶向技术的结果，缺乏功能性CD40配体的非人动物。
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公开(公告)号：US5565321A
公开(公告)日：1996-10-15
申请号：US184422
申请日：1994-01-21
IPC分类号： A01K67/027 , A61K31/70 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/705 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/85 , C12Q1/68 , G01N33/50 , G01N33/566 , C12F19/34
CPC分类号： C12N15/8509 , A01K67/0276 , C07K14/70575 , C07K19/00 , C12Q1/6883 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0381 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Q2600/156 , C12Q2600/158
摘要： There is disclosed a method of detecting a mutation in a CD40 ligand gene, comprising isolating nucleic acid from an individual, selectively amplifying nucleic acid derived from the CD40 ligand gene, and analyzing the amplified nucleic acid to determine if there is a mutation (or mutations) in the CD40 ligand gene. The ability of a CD40 ligand protein expressed from the gene may be determined. Methods of treating a syndrome that results in elevated levels of serum IgM and diminished levels of all other isotypes of immunoglobulins are also disclosed. Also disclosed are non-human animals that lack functional CD40 ligand as a result of gene targeting technology.
摘要翻译： 公开了一种检测CD40配体基因突变的方法，包括分离来自个体的核酸，选择性扩增衍生自CD40配体基因的核酸，并分析扩增的核酸以确定是否存在突变（或突变 ）在CD40配体基因中。 可以测定从该基因表达的CD40配体蛋白的能力。 还公开了治疗导致血清IgM水平升高和免疫球蛋白的所有其他同种型降低的综合征的方法。 还公开了作为基因靶向技术的结果，缺乏功能性CD40配体的非人动物。
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