公开(公告)号：US20100179445A1

公开(公告)日：2010-07-15

申请号：US12687963

申请日：2010-01-15

申请人： Richard J. O'Brien ,  D. Curtis Deno ,  David A. Anderson ,  David R. Bloem

发明人： Richard J. O'Brien ,  D. Curtis Deno ,  David A. Anderson ,  David R. Bloem

IPC分类号： A61B5/0402 ,  G08B23/00

CPC分类号： A61B5/0002 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/7207

摘要： A medical device includes one or more sensors used to acquire a multi-dimensional signal. In one embodiment, principal component analysis is performed on the multi-dimensional signal to produce signal data. The principal component analysis results are used to cancel signal artifact in one embodiment. A medical device controller produces one of a therapy control and a diagnostic output in response to the signal data.

公开(公告)号：US08391944B2

公开(公告)日：2013-03-05

申请号：US12687954

申请日：2010-01-15

申请人： Richard J. O'Brien ,  D. Curtis Deno ,  David A. Anderson ,  David R. Bloem

发明人： Richard J. O'Brien ,  D. Curtis Deno ,  David A. Anderson ,  David R. Bloem

IPC分类号： A61B5/1455 ,  A61N1/365

CPC分类号： A61N1/36514 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02028 ,  A61B5/0464 ,  A61B5/7207

摘要： A medical device includes one or more sensors used to acquire a multi-dimensional signal. In one embodiment, principal component analysis is performed on the multi-dimensional signal to produce signal data. The principal component analysis results are used to cancel signal artifact in one embodiment. A medical device controller produces one of a therapy control and a diagnostic output in response to the signal data.

摘要翻译： 医疗装置包括用于获取多维信号的一个或多个传感器。 在一个实施例中，对多维信号执行主成分分析以产生信号数据。 在一个实施例中，主成分分析结果用于消除信号伪像。 医疗设备控制器响应于信号数据产生治疗控制和诊断输出之一。

公开(公告)号：US20100179444A1

公开(公告)日：2010-07-15

申请号：US12687946

申请日：2010-01-15

申请人： Richard J. O'Brien ,  D. Curtis Deno ,  David A. Anderson ,  David R. Bloem

发明人： Richard J. O'Brien ,  D. Curtis Deno ,  David A. Anderson ,  David R. Bloem

IPC分类号： A61B5/0402 ,  G08B23/00

CPC分类号： A61B5/0205 ,  A61B5/1455 ,  A61B5/7207 ,  A61N1/3718 ,  A61N1/3925 ,  G06K9/00503 ,  G06K9/6247 ,  G06K2009/00939

摘要： A medical device having a sensor sensing an n-dimensional signal during a first known variable condition and during a second known variable condition different from the first known variable condition, a processor performing principal component analysis (PCA) on the sensed n-dimensional signal to generate a first template corresponding to a principal component of variation associated with the first known variable condition and a second template corresponding to a principal component of variation associated with the second known variable condition, a storage device storing the first template and the second template, and a controller detecting a patient condition in response to the stored templates.

摘要翻译： 一种医疗装置，其具有在第一已知可变条件期间和在与第一已知可变条件不同的第二已知可变条件期间感测n维信号的传感器，处理器对所感测的n维信号执行主分量分析（PCA） 生成对应于与第一已知可变条件相关联的变化的主成分的第一模板和对应于与第二已知可变条件相关联的变化的主成分的第二模板，存储第一模板和第二模板的存储装置，以及 响应于所存储的模板检测患者状况的控制器。

公开(公告)号：US08706202B2

公开(公告)日：2014-04-22

申请号：US12687946

申请日：2010-01-15

申请人： Richard J. O'Brien ,  D. Curtis Deno ,  David A. Anderson ,  David R. Bloem

发明人： Richard J. O'Brien ,  D. Curtis Deno ,  David A. Anderson ,  David R. Bloem

IPC分类号： A61B5/04

CPC分类号： A61B5/0205 ,  A61B5/1455 ,  A61B5/7207 ,  A61N1/3718 ,  A61N1/3925 ,  G06K9/00503 ,  G06K9/6247 ,  G06K2009/00939

摘要： A medical device having a sensor sensing an n-dimensional signal during a first known variable condition and during a second known variable condition different from the first known variable condition, a processor performing principal component analysis (PCA) on the sensed n-dimensional signal to generate a first template corresponding to a principal component of variation associated with the first known variable condition and a second template corresponding to a principal component of variation associated with the second known variable condition, a storage device storing the first template and the second template, and a controller detecting a patient condition in response to the stored templates.

摘要翻译： 一种医疗装置，其具有在第一已知可变条件期间和在与第一已知可变条件不同的第二已知可变条件期间感测n维信号的传感器，处理器对所感测的n维信号执行主分量分析（PCA） 生成对应于与第一已知可变条件相关联的变化的主成分的第一模板和对应于与第二已知可变条件相关联的变化的主成分的第二模板，存储第一模板和第二模板的存储装置，以及 响应于所存储的模板检测患者状况的控制器。

公开(公告)号：US20100179611A1

公开(公告)日：2010-07-15

申请号：US12687954

申请日：2010-01-15

申请人： Richard J. O'Brien ,  D. Curtis Deno ,  David A. Anderson ,  David R. Bloem

发明人： Richard J. O'Brien ,  D. Curtis Deno ,  David A. Anderson ,  David R. Bloem

IPC分类号： A61N1/00 ,  G08B23/00 ,  A61B5/00

CPC分类号： A61N1/36514 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02028 ,  A61B5/0464 ,  A61B5/7207

摘要： A medical device includes one or more sensors used to acquire a multi-dimensional signal. In one embodiment, principal component analysis is performed on the multi-dimensional signal to produce signal data. The principal component analysis results are used to cancel signal artifact in one embodiment. A medical device controller produces one of a therapy control and a diagnostic output in response to the signal data.

摘要翻译： 医疗装置包括用于获取多维信号的一个或多个传感器。 在一个实施例中，对多维信号执行主分量分析以产生信号数据。 在一个实施例中，主成分分析结果用于消除信号伪像。 医疗设备控制器响应于信号数据产生治疗控制和诊断输出之一。

公开(公告)号：US08463346B2

公开(公告)日：2013-06-11

申请号：US12797800

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/00

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.

摘要翻译： 用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测 通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用 光检测器输出信号。

公开(公告)号：US08346332B2

公开(公告)日：2013-01-01

申请号：US12797811

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/00

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a first combination of a light source and a light detector to emit light into a volume of tissue, detect light scattered by the volume of tissue, and provide a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal, compute a measure of tissue oxygenation in response to the light detector output signal, and detect tissue hypoxia using the measure of tissue oxygenation.

摘要翻译： 用于监测患者状况的医疗装置包括光源和光检测器的第一组合，以将光发射到组织的体积中，检测由组织体积散射的光，并提供对应于组织的强度的第一输出信号 检测到光。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号，计算响应中组织氧合的量度 到光检测器输出信号，并使用组织氧合的测量来检测组织缺氧。

公开(公告)号：US20100317941A1

公开(公告)日：2010-12-16

申请号：US12797811

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/1455

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a first combination of a light source and a light detector to emit light into a volume of tissue, detect light scattered by the volume of tissue, and provide a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal, compute a measure of tissue oxygenation in response to the light detector output signal, and detect tissue hypoxia using the measure of tissue oxygenation.

摘要翻译： 用于监测患者状况的医疗装置包括光源和光检测器的第一组合，以将光发射到组织的体积中，检测由组织体积散射的光，并提供对应于组织的强度的第一输出信号 检测到光。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号，计算响应中组织氧合的量度 到光检测器输出信号，并使用组织氧合的测量来检测组织缺氧。

公开(公告)号：US20100317940A1

公开(公告)日：2010-12-16

申请号：US12797800

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/1455

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.

摘要翻译： 用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测 通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用 光检测器输出信号。

公开(公告)号：US10179242B2

公开(公告)日：2019-01-15

申请号：US12797815

申请日：2010-06-10

申请人： Can Cinbis ,  James K. Carney ,  Jonathan L. Kuhn ,  David A. Anderson

发明人： Can Cinbis ,  James K. Carney ,  Jonathan L. Kuhn ,  David A. Anderson

IPC分类号： A61N1/36 ,  A61B5/145 ,  A61N1/365

摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.