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公开(公告)号:US09108905B2
公开(公告)日:2015-08-18
申请号:US12348064
申请日:2009-01-02
IPC分类号: A61K31/15 , A61P25/00 , A61K31/167 , A61K31/192 , C07C251/40 , A61K45/06 , C07C45/00 , C07C49/235 , C07C251/00
CPC分类号: C07C251/40 , A61K31/15 , A61K45/06 , C07C45/004 , C07C49/235 , C07C251/00 , A61K2300/00
摘要: Compounds of formula (I) wherein R1, R2, R3, m, and Y are defined in the specification are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 其中R1,R2,R3,m和Y在说明书中定义的式(I)化合物是TRPA1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US08877784B2
公开(公告)日:2014-11-04
申请号:US12348065
申请日:2009-01-02
IPC分类号: A61K31/44 , A01N43/40 , A01N33/00 , A61K31/13 , A61K31/16 , A01N33/24 , A61K31/15 , C07D213/56 , C07D213/53 , C07D333/20 , C07D215/12 , C07D217/14
CPC分类号: C07D333/22 , A61K31/381 , A61K31/44 , A61K31/47 , A61K31/472 , A61K45/06 , C07D213/53 , C07D213/61 , C07D213/64 , C07D215/12 , C07D217/14 , C07D333/20
摘要: Compounds of formula (I) wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 在描述中定义R1,R2,R3和Y的式(Ⅰ)化合物是TRPA1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US20090176883A1
公开(公告)日:2009-07-09
申请号:US12348064
申请日:2009-01-02
IPC分类号: A61K31/15 , A61P25/00 , A61K31/167 , A61K31/192
CPC分类号: C07C251/40 , A61K31/15 , A61K45/06 , C07C45/004 , C07C49/235 , C07C251/00 , A61K2300/00
摘要: Compounds of formula (I) wherein R1, R2, R3, m, and Y are defined in the specification are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 其中R1,R2,R3,m和Y在说明书中定义的式(I)化合物是TRPA1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US20090264480A1
公开(公告)日:2009-10-22
申请号:US12348065
申请日:2009-01-02
IPC分类号: A61K31/44 , C07D213/54 , A61P25/00
CPC分类号: C07D333/22 , A61K31/381 , A61K31/44 , A61K31/47 , A61K31/472 , A61K45/06 , C07D213/53 , C07D213/61 , C07D213/64 , C07D215/12 , C07D217/14 , C07D333/20
摘要: Compounds of formula (I) wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 在描述中定义R1,R2,R3和Y的式(Ⅰ)化合物是TRPA1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US08604053B2
公开(公告)日:2013-12-10
申请号:US12579821
申请日:2009-10-15
申请人: Arthur R. Gomtsyan , Eric A. Voight , Erol K. Bayburt , Jun Chen , Jerome F. Daanen , Stanley DiDomenico , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt
发明人: Arthur R. Gomtsyan , Eric A. Voight , Erol K. Bayburt , Jun Chen , Jerome F. Daanen , Stanley DiDomenico , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt
IPC分类号: C07D405/12 , A61K31/4709
CPC分类号: C07D311/74 , C07D405/12
摘要: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 本文公开了式(I)的化合物或其药学上可接受的盐,溶剂合物,前药,前药的盐或其组合,其中R1,R2,R3,R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US08609692B2
公开(公告)日:2013-12-17
申请号:US12579803
申请日:2009-10-15
申请人: Arthur R. Gomtsyan , Erol K. Bayburt , Jun Chen , Stanley DiDomenico , Jerome F. Daanen , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt , Eric A. Voight
发明人: Arthur R. Gomtsyan , Erol K. Bayburt , Jun Chen , Stanley DiDomenico , Jerome F. Daanen , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt , Eric A. Voight
IPC分类号: C07D405/12 , C07D311/02 , A61K31/47 , A61K31/416
CPC分类号: C07D405/12 , C07D311/74
摘要: Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 本文公开了式(I)化合物或其药学上可接受的盐,溶剂合物,前药,前药盐或其组合,其中R1,R2,R3,R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US20100120846A1
公开(公告)日:2010-05-13
申请号:US12579803
申请日:2009-10-15
申请人: Arthur R. Gomtsyan , Erol K. Bayburt , Jun Chen , Stanley DiDomenico , Jerome F. Daanen , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt , Eric A. Voight
发明人: Arthur R. Gomtsyan , Erol K. Bayburt , Jun Chen , Stanley DiDomenico , Jerome F. Daanen , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt , Eric A. Voight
IPC分类号: A61K31/47 , A61K31/416 , A61K31/352 , C07D405/12 , C07D311/02 , A61P19/02 , A61P29/00
CPC分类号: C07D405/12 , C07D311/74
摘要: Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 本文公开了式(I)化合物或其药学上可接受的盐,溶剂合物,前药,前药盐或其组合,其中R1,R2,R3,R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:US20100137360A1
公开(公告)日:2010-06-03
申请号:US12579821
申请日:2009-10-15
申请人: Arthur R. Gomtsyan , Eric A. Voight , Erol K. Bayburt , Jun Chen , Jerome F. Daanen , Stanley DiDomenico , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt
发明人: Arthur R. Gomtsyan , Eric A. Voight , Erol K. Bayburt , Jun Chen , Jerome F. Daanen , Stanley DiDomenico , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt
IPC分类号: A61K31/4709 , A61P35/00 , A61P1/16 , A61P3/04 , A61P9/10 , A61P11/06 , C07D405/12 , C07D311/02 , A61K31/352 , A61K31/416
CPC分类号: C07D311/74 , C07D405/12
摘要: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译: 本文公开了式(I)的化合物或其药学上可接受的盐,溶剂合物,前药,前药的盐或其组合,其中R1,R2,R3,R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号:USD1019259S1
公开(公告)日:2024-03-26
申请号:US29911297
申请日:2023-08-31
申请人: Jun Chen
设计人: Jun Chen
摘要: FIG. 1 is a top perspective view of a bottle cap, showing my new design;
FIG. 2 is a bottom perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top view thereof; and,
FIG. 8 is a bottom view thereof.
The dashed broken lines depict portions of the bottle cap that form no part of the claim design.-
公开(公告)号:US11569440B2
公开(公告)日:2023-01-31
申请号:US15412076
申请日:2017-01-23
申请人: Yimin Guo , Rongfu Xiao , Jun Chen
发明人: Yimin Guo , Rongfu Xiao , Jun Chen
摘要: The invention disclosed a method to make an implanted hard mask with ultra-small dimensions for fabricating integrated nonvolatile random access memory. Instead of directly depositing hard mask material on top of the memory film stack element, we first make ultra-small VIA holes on a pattern transfer molding (PTM) layer using a reverse memory mask, then fill in the hard mask material into the VIA holes within the PTM material. Ultra-small hard mask pillars are formed after removing the PTM material. To improve the adhesion of the hard mask pillars with the underneath memory stack element, a hard mask sustaining element (HMSE) is added below PTM. Due to a better materials adhesion between HMSE and the hard mask, a stronger hard mask array can be formed.
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