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公开(公告)号：US08609692B2
公开(公告)日：2013-12-17
申请号：US12579803
申请日：2009-10-15
Applicant: Arthur R. Gomtsyan , Erol K. Bayburt , Jun Chen , Stanley DiDomenico , Jerome F. Daanen , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt , Eric A. Voight
Inventor： Arthur R. Gomtsyan , Erol K. Bayburt , Jun Chen , Stanley DiDomenico , Jerome F. Daanen , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt , Eric A. Voight
IPC: C07D405/12 , C07D311/02 , A61K31/47 , A61K31/416
CPC classification number: C07D405/12 , C07D311/74
Abstract: Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，溶剂合物，前药，前药盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20100120846A1
公开(公告)日：2010-05-13
申请号：US12579803
申请日：2009-10-15
Applicant: Arthur R. Gomtsyan , Erol K. Bayburt , Jun Chen , Stanley DiDomenico , Jerome F. Daanen , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt , Eric A. Voight
Inventor： Arthur R. Gomtsyan , Erol K. Bayburt , Jun Chen , Stanley DiDomenico , Jerome F. Daanen , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt , Eric A. Voight
IPC: A61K31/47 , A61K31/416 , A61K31/352 , C07D405/12 , C07D311/02 , A61P19/02 , A61P29/00
CPC classification number: C07D405/12 , C07D311/74
Abstract: Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，溶剂合物，前药，前药盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US08802711B2
公开(公告)日：2014-08-12
申请号：US13426732
申请日：2012-03-22
Applicant: Arthur Gomtsyan , Jerome F. Daanen , Gregory A. Gfesser , Michael E. Kort , Chih-Hung Lee , Heath A. McDonald , Pamela S. Puttfarcken , Eric A. Voight , Philip R. Kym
Inventor： Arthur Gomtsyan , Jerome F. Daanen , Gregory A. Gfesser , Michael E. Kort , Chih-Hung Lee , Heath A. McDonald , Pamela S. Puttfarcken , Eric A. Voight , Philip R. Kym
IPC: C07D265/36 , C07D215/38 , C07D217/02 , C07D231/56 , A61K31/17 , A61K31/538 , A61K31/192 , A61K31/472
CPC classification number: C07C275/32 , C07C2601/08 , C07C2602/08 , C07D209/08 , C07D215/38 , C07D217/02 , C07D231/56 , C07D239/80 , C07D263/48 , C07D265/36 , C07D401/04 , C07D413/12 , C07D417/12
Abstract: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, wherein X1, X2, X3, X4, J, K, L, X5, X6, Rb, G2, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，溶剂化物或其组合，其中X1，X2，X3，X4，J，K，L，X5，X6，Rb，G2和m在本说明书中定义 。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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Patent Agency Ranking
公开(公告)号：US09012651B2
公开(公告)日：2015-04-21
申请号：US13428259
申请日：2012-03-23
Applicant: Bruce Clapham , Phil B. Cox , Michael J. Dart , Arthur Gomtsyan , Tammie K. Jinkerson , Ryan G. Keddy , Michael E. Kort , Philip R. Kym , Mark Matulenko , Robert G. Schmidt , Clara I. Villamil , Eric A. Voight , Kevin R. Woller
Inventor： Bruce Clapham , Phil B. Cox , Michael J. Dart , Arthur Gomtsyan , Tammie K. Jinkerson , Ryan G. Keddy , Michael E. Kort , Philip R. Kym , Mark Matulenko , Robert G. Schmidt , Clara I. Villamil , Eric A. Voight , Kevin R. Woller
IPC: C07D401/04 , C07D401/14 , C07D409/04 , C07D417/04 , A61K31/444 , A61P29/00 , C07D213/61 , A61K31/44 , A61K31/505 , C07D211/06 , C07D239/28 , C07D239/30 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D405/14 , C07D213/74 , C07D401/10 , C07D405/04 , C07D239/26 , C07D417/10 , C07D213/38 , C07D213/64
CPC classification number: C07D213/61 , A61K31/44 , A61K31/505 , C07D211/06 , C07D213/38 , C07D213/64 , C07D213/643 , C07D213/74 , C07D239/26 , C07D239/28 , C07D239/30 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
Abstract: Disclosed herein are modulators of TRPV3 of formula (I) wherein X1, X2, R1, R2, Rx, and n are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中X1，X2，R1，R2，Rx和n如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20120245163A1
公开(公告)日：2012-09-27
申请号：US13426732
申请日：2012-03-22
Applicant: Arthur Gomtsyan , Jerome F. Daanen , Gregory A. Gfesser , Michael E. Kort , Chih-Hung Lee , Heath A. McDonald , Pamela S. Puttfarcken , Eric A. Voight , Philip R. Kym
Inventor： Arthur Gomtsyan , Jerome F. Daanen , Gregory A. Gfesser , Michael E. Kort , Chih-Hung Lee , Heath A. McDonald , Pamela S. Puttfarcken , Eric A. Voight , Philip R. Kym
IPC: A61K31/17 , C07D265/36 , A61K31/538 , C07D215/38 , A61K31/192 , C07D217/02 , A61K31/472 , C07D231/56 , A61K31/416 , A61P25/00 , C07C275/32 , A61K31/4704
CPC classification number: C07C275/32 , C07C2601/08 , C07C2602/08 , C07D209/08 , C07D215/38 , C07D217/02 , C07D231/56 , C07D239/80 , C07D263/48 , C07D265/36 , C07D401/04 , C07D413/12 , C07D417/12
Abstract: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, wherein X1, X2, X3, X4, J, K, L, X5, X6, Rb, G2, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，溶剂化物或其组合，其中X1，X2，X3，X4，J，K，L，X5，X6，Rb，G2和m在本说明书中定义 。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US20120245124A1
公开(公告)日：2012-09-27
申请号：US13428259
申请日：2012-03-23
Applicant: Bruce Clapham , Phil B. Cox , Michael J. Dart , Arthur Gomtsyan , Tammie K. Jinkerson , Ryan G. Keddy , Michael E. Kort , Philip R. Kym , Mark Matulenko , Robert G. Schmidt , Clara I. Villamil , Eric A. Voight , Kevin R. Woller
Inventor： Bruce Clapham , Phil B. Cox , Michael J. Dart , Arthur Gomtsyan , Tammie K. Jinkerson , Ryan G. Keddy , Michael E. Kort , Philip R. Kym , Mark Matulenko , Robert G. Schmidt , Clara I. Villamil , Eric A. Voight , Kevin R. Woller
IPC: A61K31/4418 , C07D401/04 , A61K31/4545 , A61K31/444 , C07D239/26 , A61K31/505 , C07D413/10 , A61K31/5377 , C07D413/12 , C07D417/10 , A61K31/541 , A61K31/506 , C07F7/10 , A61K31/695 , C07D401/14 , A61K31/496 , A61P29/00 , C07D413/14 , C07D213/36
CPC classification number: C07D213/61 , A61K31/44 , A61K31/505 , C07D211/06 , C07D213/38 , C07D213/64 , C07D213/643 , C07D213/74 , C07D239/26 , C07D239/28 , C07D239/30 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/12
Abstract: Disclosed herein are modulators of TRPV3 of formula (I) wherein X1, X2, R1, R2, Rx, and n are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Abstract translation: 本文公开了式（I）的TRPV3的调节剂，其中X1，X2，R1，R2，Rx和n如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20100137360A1
公开(公告)日：2010-06-03
申请号：US12579821
申请日：2009-10-15
Applicant: Arthur R. Gomtsyan , Eric A. Voight , Erol K. Bayburt , Jun Chen , Jerome F. Daanen , Stanley DiDomenico , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt
Inventor： Arthur R. Gomtsyan , Eric A. Voight , Erol K. Bayburt , Jun Chen , Jerome F. Daanen , Stanley DiDomenico , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt
IPC: A61K31/4709 , A61P35/00 , A61P1/16 , A61P3/04 , A61P9/10 , A61P11/06 , C07D405/12 , C07D311/02 , A61K31/352 , A61K31/416
CPC classification number: C07D311/74 , C07D405/12
Abstract: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）的化合物或其药学上可接受的盐，溶剂合物，前药，前药的盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US08604053B2
公开(公告)日：2013-12-10
申请号：US12579821
申请日：2009-10-15
Applicant: Arthur R. Gomtsyan , Eric A. Voight , Erol K. Bayburt , Jun Chen , Jerome F. Daanen , Stanley DiDomenico , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt
Inventor： Arthur R. Gomtsyan , Eric A. Voight , Erol K. Bayburt , Jun Chen , Jerome F. Daanen , Stanley DiDomenico , Michael E. Kort , Philip R. Kym , Heath A. McDonald , Richard J. Perner , Robert G. Schmidt
IPC: C07D405/12 , A61K31/4709
CPC classification number: C07D311/74 , C07D405/12
Abstract: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 本文公开了式（I）的化合物或其药学上可接受的盐，溶剂合物，前药，前药的盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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