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公开(公告)号：US08193203B2
公开(公告)日：2012-06-05
申请号：US12467575
申请日：2009-05-18
申请人： Richard L. Beard , Tien T. Duong , Thong H. Vu , Vidyasagar Vuligonda , John E. Donello , Michael E. Garst , Gerard A. Rodrigues
发明人： Richard L. Beard , Tien T. Duong , Thong H. Vu , Vidyasagar Vuligonda , John E. Donello , Michael E. Garst , Gerard A. Rodrigues
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72
CPC分类号： C07D401/12
摘要： A compound represented by the structural formula: Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 由结构式表示的化合物：还公开了与其有关的治疗方法，组合物和药物。
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2.发明申请Indole Compounds having sphingosine-1-phosphate (S1P) receptor antagonist 有权具有鞘氨醇-1-磷酸（S1P）受体拮抗剂的吲哚化合物公开(公告)号：US20070232682A1
公开(公告)日：2007-10-04
申请号：US11690637
申请日：2007-03-23
IPC分类号： A61K31/405 , C07D209/04
CPC分类号： C07D209/14 , C07D209/12 , C07D209/30 , C07D209/40 , C07D209/42 , C07D405/12 , C07D409/06 , C07D413/04 , C07F9/5728
摘要： The present invention provides novel compounds having the following general formula I wherein: A, B, X, Y, R1, R2, R3, R4, n, o and p are as defined in the specification. Such compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions or diseases and wound healing.
摘要翻译： 本发明提供具有以下通式I的新化合物，其中：A，B，X，Y，R 1，R 2，R 3， >，R 4，n，o和p如说明书中所定义。 这样的化合物可用于治疗选自青光眼，干眼症，血管发生，心血管疾病或疾病和伤口愈合的疾病或病症。
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3.发明授权Indole compounds having sphingosine-1-phosphate (S1P) receptor antagonist 有权具有鞘氨醇-1-磷酸（S1P）受体拮抗剂的吲哚化合物公开(公告)号：US08097644B2
公开(公告)日：2012-01-17
申请号：US11690637
申请日：2007-03-23
IPC分类号： A61K31/405 , C07D209/04
CPC分类号： C07D209/14 , C07D209/12 , C07D209/30 , C07D209/40 , C07D209/42 , C07D405/12 , C07D409/06 , C07D413/04 , C07F9/5728
摘要： The present invention provides novel compounds having the following general formula I wherein: A, B, X, Y, R1, R2, R3, R4, n, o and p are as defined in the specification. Such compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions or diseases and wound healing.
摘要翻译： 本发明提供具有以下通式I的新化合物，其中：A，B，X，Y，R 1，R 2，R 3，R 4，n，o和p如说明书中所定义。 这样的化合物可用于治疗选自青光眼，干眼症，血管发生，心血管疾病或疾病和伤口愈合的疾病或病症。
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4.发明授权Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity 有权具有甲酰肽受体1（FPRL-1）激动剂或拮抗剂活性的环烯基和环烯基-1,2-二羧酸化合物的衍生物公开(公告)号：US08618163B2
公开(公告)日：2013-12-31
申请号：US13168464
申请日：2011-06-24
CPC分类号： C07C323/40 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/195 , A61K31/215 , A61K31/216 , A61K31/4035 , A61K31/44 , C07C233/58 , C07C233/59 , C07C311/46 , C07C2603/94 , C07D213/75 , C07D493/08
摘要： The invention provides well defined compounds having FPRL-1 agonist or antagonist activity. As such, the compounds of the invention are useful for treating a variety of ocular disorders.
摘要翻译： 本发明提供了具有FPRL-1激动剂或拮抗剂活性的明确定义的化合物。 因此，本发明的化合物可用于治疗各种眼部疾病。
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5.发明申请DIHYDRONAPHTHALENE AND NAPHTHALENE DERIVATIVES AS N-FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS 有权作为N-甲基肽受体样-1（FPRL-1）受体调节剂的二氢萘和萘衍生物公开(公告)号：US20120238628A1
公开(公告)日：2012-09-20
申请号：US13409228
申请日：2012-03-01
申请人： Vidyasagar Vuligonda , Richard L. Beard , Thong Vu , John E. Donello , Veena Viswanath , Michael E. Garst
发明人： Vidyasagar Vuligonda , Richard L. Beard , Thong Vu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： A61K31/196 , A61P27/02 , A61P35/00 , A61P35/04 , A61P29/00 , A61P11/00 , A61P31/18 , A61P9/00 , A61P25/00 , A61P11/06 , A61P37/08 , A61P19/04 , A61P17/06 , A61P25/28 , A61P19/02 , A61P31/00 , A61P1/00 , A61P9/10 , A61P17/00 , A61P17/10 , A61P17/12 , A61P17/14 , A61P17/08 , C07C229/46
CPC分类号： C07C235/84 , C07C233/59 , C07C235/82 , C07C2602/10
摘要： The present invention relates to novel dihydronaphthalene and naphthalene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
摘要翻译： 本发明涉及新型二氢萘和萘衍生物，其制备方法，含有它们的药物组合物及其作为N-甲酰基肽受体1（FPRL-1）受体调节剂的药物的用途。
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公开(公告)号：US08653299B2
公开(公告)日：2014-02-18
申请号：US13409228
申请日：2012-03-01
申请人： Vidyasagar Vuligonda , Richard L. Beard , Thong Vu , John E. Donello , Veena Viswanath , Michael E. Garst
发明人： Vidyasagar Vuligonda , Richard L. Beard , Thong Vu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： C07C229/46 , C07C233/65 , A61K31/195 , A61K31/16
CPC分类号： C07C235/84 , C07C233/59 , C07C235/82 , C07C2602/10
摘要： The present invention relates to novel dihydronaphthalene and naphthalene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
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7.发明授权Polycyclic pyrrolidine-2,5-dione derivatives as -formyl peptide receptor like-1 (FPRL-1) receptor modulators 失效多环吡咯烷-2,5-二酮衍生物作为正 - 甲基肽受体1（FPRL-1）受体调节剂公开(公告)号：US08440684B2
公开(公告)日：2013-05-14
申请号：US13541000
申请日：2012-07-03
申请人： Richard L. Beard , Vidyasagar Vuligonda , Thong Vu , John E. Donello , Veena Viswanath , Michael E. Garst
发明人： Richard L. Beard , Vidyasagar Vuligonda , Thong Vu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： A61K31/454 , C07D213/61 , C07D209/56
CPC分类号： C07D209/96 , C07D401/12
摘要： The present invention relates to novel polycyclic pyrrolidine-2,5-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
摘要翻译： 本发明涉及新型多环吡咯烷-2,5-二酮衍生物，其制备方法，含有它们的药物组合物及其作为N-甲酰基肽受体1（FPRL-1）受体调节剂的药物的用途。
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8.发明申请POLYCYCLIC PYRROLIDINE-2,5-DIONE DERIVATIVES AS -FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS 失效多肽吡咯烷-2,5-二酮衍生物作为受体受体样受体1（FPRL-1）受体调节剂公开(公告)号：US20130018067A1
公开(公告)日：2013-01-17
申请号：US13541000
申请日：2012-07-03
申请人： Richard L. Beard , Vidyasagar Vuligonda , Thong Vu , John E. Donello , Veena Viswanath , Michael E. Garst
发明人： Richard L. Beard , Vidyasagar Vuligonda , Thong Vu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号： A61K31/4035 , C07D401/12 , A61K31/4439 , A61P27/02 , A61P27/04 , A61P37/08 , A61P9/10 , A61P9/00 , A61P33/02 , A61P31/06 , A61P31/04 , A61P35/04 , A61P35/00 , A61P31/18 , A61P25/00 , A61P29/00 , A61P27/10 , A61P11/06 , A61P11/00 , A61P25/28 , A61P31/00 , A61P17/00 , A61P17/02 , A61P1/00 , A61P17/06 , A61P17/08 , A61P19/02 , A61P27/06 , A61P31/12 , A61P17/10 , C07D209/48
CPC分类号： C07D209/96 , C07D401/12
摘要： The present invention relates to novel polycyclic pyrrolidine-2,5-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
摘要翻译： 本发明涉及新型多环吡咯烷-2,5-二酮衍生物，其制备方法，含有它们的药物组合物及其作为N-甲酰基肽受体1（FPRL-1）受体调节剂的药物的用途。
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公开(公告)号：US09090624B2
公开(公告)日：2015-07-28
申请号：US13565478
申请日：2012-08-02
申请人： Vidyasagar Vuligonda , Richard L. Beard , Thong Vu , John E. Donello , Gerard Rodrigues , Veena Viswanath , Michael E. Garst
发明人： Vidyasagar Vuligonda , Richard L. Beard , Thong Vu , John E. Donello , Gerard Rodrigues , Veena Viswanath , Michael E. Garst
IPC分类号： C07D495/04 , A61K31/517 , A61K31/519 , C07D401/12
CPC分类号： C07D495/04 , C07D401/12
摘要： The present invention relates to novel aromatic bicyclic derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the CXCR4 receptor.
摘要翻译： 本发明涉及新的芳族二环衍生物，其制备方法，含有它们的药物组合物及其作为药物作为CXCR4受体调节剂的用途。
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公开(公告)号：US20130035347A1
公开(公告)日：2013-02-07
申请号：US13565478
申请日：2012-08-02
申请人： Vidyasagar Vuligonda , Richard L. Beard , Thong Vu , John E. Donello , Gerard Rodrigues , Veena Viswanath , Michael E. Garst
发明人： Vidyasagar Vuligonda , Richard L. Beard , Thong Vu , John E. Donello , Gerard Rodrigues , Veena Viswanath , Michael E. Garst
IPC分类号： A61K31/517 , C07D495/04 , A61K31/519 , A61P27/02 , A61P27/06 , A61P29/00 , A61P37/00 , A61P25/00 , A61P1/00 , A61P1/04 , A61P19/04 , A61P11/06 , A61P11/00 , A61P3/10 , A61P9/10 , A61P17/06 , A61P19/02 , A61P37/06 , A61P17/00 , A61P35/00 , A61P35/04 , C07D401/12
CPC分类号： C07D495/04 , C07D401/12
摘要： The present invention relates to novel aromatic bicyclic derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the CXCR4 receptor.
摘要翻译： 本发明涉及新的芳族二环衍生物，其制备方法，含有它们的药物组合物及其作为药物作为CXCR4受体调节剂的用途。
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