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    Silicone Adhesive For Adhesion To Wet Surfaces
    6.
    发明申请
    Silicone Adhesive For Adhesion To Wet Surfaces 有权
    硅胶粘合剂用于粘合湿表面

    公开(公告)号：US20080295960A1

    公开(公告)日：2008-12-04

    申请号：US12158718

    申请日：2007-01-03

    申请人： Gerald Kenneth Schalau II ,  Xavier Jean-Paul Thomas ,  Victor Albert Raul ,  David Clayton Gantner

    发明人： Gerald Kenneth Schalau II ,  Xavier Jean-Paul Thomas ,  Victor Albert Raul ,  David Clayton Gantner

    IPC分类号： C09J7/04 ,  C08L83/06 ,  A61K9/00 ,  A61K9/70

    CPC分类号： A61K9/7069 ,  A61K9/7007 ,  A61M5/14248 ,  A61M2205/0205 ,  A61M2205/0238 ,  C08G2170/40 ,  C08L83/00 ,  C09J183/04

    摘要： A silicone adhesive composition used for adhering a device or a substance to a wet surface contains (i) a silicone resin that is cohydrolysis product of a trialkyl hydrolyzable silane and an alkyl silicate in which the cohydrolysis product contains a plurality of silicon-bonded hydroxy groups; (ii) a linear organopolysiloxane fluid containing terminal silicon-bonded hydroxy groups having a viscosity above 200,000 mm2/s at 25° C.; (iii) a trialkylsiloxy terminated polyorganosiloxane fluid having a viscosity of 100,000-600,000 mm2/s at 25° C.; (iv) a water soluble muco-adhesive polymer selected from the group consisting of a poly(ethylene oxide) polymer having a molecular weight of 100,000 to 8,000,000, an acrylic acid polymer having a molecular weight of 500,000 to 4,500,000,000, and a hydroxyethylcellulose polymer having a molecular weight of 90,000 to 1,300,000,000; and optionally, (v) a solvent selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, esters, volatile linear and cyclic silicone compounds. Other components such as a silicone polyether, a silicone wax, a drug, an excipient, and/or an active ingredient can also be included.

    摘要翻译： 用于将装置或物质粘附到湿表面的硅氧烷粘合剂组合物包含（i）三烷基可水解硅烷和烷基硅酸盐的共水解产物的硅氧烷树脂，其中共水解产物含有多个与硅键合的羟基 ; （ii）在25℃下具有粘度高于200,000mm 2 / s的末端硅键合羟基的线性有机聚硅氧烷流体; （iii）25℃粘度为100,000-600,000mm 2 / s的三烷基甲硅烷氧基封端聚有机硅氧烷流体; （iv）选自分子量为100,000至800,000的聚（环氧乙烷）聚合物，分子量为500,000至4,500,000,000的丙烯酸聚合物的水溶性粘性粘合剂聚合物和具有 分子量为9万至13亿; 和（v）选自脂族烃，芳族烃，酯，挥发性线性和环状硅氧烷化合物的溶剂。 还可以包括其它组分如硅氧烷聚醚，硅氧烷蜡，药物，赋形剂和/或活性成分。

    Drug Delivery Dispersion And Film Formed Therefrom
    7.
    发明申请
    Drug Delivery Dispersion And Film Formed Therefrom 审中-公开
    药物分散和成膜形成

    公开(公告)号：US20130287856A1

    公开(公告)日：2013-10-31

    申请号：US13976312

    申请日：2011-12-27

    申请人： Virginie Caprasse ,  Fabrizio S. Galeone ,  Leon Andre Marteaux ,  Anke Sieg ,  Xavier Jean-Paul Thomas

    发明人： Virginie Caprasse ,  Fabrizio S. Galeone ,  Leon Andre Marteaux ,  Anke Sieg ,  Xavier Jean-Paul Thomas

    IPC分类号： A61K9/107

    CPC分类号： A61K9/1075 ,  A61K9/5031 ,  A61K9/7015 ,  A61K47/24

    摘要： An active agent delivery dispersion includes water, 1 to 98 weight percent of a plurality of encapsulated particles dispersed in the water, and 0.1 to 20 weight percent of an active agent, each based on a total weight of the dispersion. The active agent is dispersed in the water independently from the plurality of encapsulated particles. Each of the particles includes a core and a layer including a silica disposed about the core. The plurality includes first and second populations of encapsulated particles. The core of the first population includes a first organopolysiloxane having at least two silicon-bonded alkenyl groups per molecule and a hydro-silylation catalyst. The core of the second population includes an organohydrogensiloxane having an average of greater than two silicon bonded hydrogen atoms per molecule and a second organopolysiloxane having at least two silicon-bonded alkenyl groups per molecule.

    摘要翻译： 活性剂递送分散体包括水，1至98重量％的分散在水中的多个包封颗粒和0.1至20重量％的活性剂，各自基于分散体的总重量。 活性剂分散在水中，独立于多个包封的颗粒。 每个颗粒包括核心和包括围绕芯部设置的二氧化硅的层。 多个包括第一和第二包封颗粒群。 第一种群的核心包括每分子具有至少两个硅键合的烯基的第一有机聚硅氧烷和加氢甲硅烷基化催化剂。 第二种群的核心包括每分子平均具有大于两个硅键合氢原子的有机氢硅氧烷，和每分子具有至少两个硅键合链烯基的第二有机聚硅氧烷。