Companion Diagnostic Assays For Endothelin Receptor Antagonists
    1.
    发明申请
    Companion Diagnostic Assays For Endothelin Receptor Antagonists 审中-公开
    内皮素受体拮抗剂的伴随诊断试验

    公开(公告)号:US20100184026A1

    公开(公告)日:2010-07-22

    申请号:US12357588

    申请日:2009-01-22

    IPC分类号: C12Q1/68 G01N33/00

    摘要: Methods for identifying cancer patients eligible to receive endothelin receptor antagonist therapy and for monitoring patient response to endothelin receptor antagonist therapy comprise assessment of the expression levels of at least one of PAI-1, uPA, TGFbeta2, IL-6, IL-8 and OPG in a patient tissue sample. The methods of the invention allow more effective identification of patients to receive endothelin receptor antagonist therapy and of determination of patient response to the therapy.

    摘要翻译: 鉴定符合接受内皮素受体拮抗剂治疗和监测患者对内皮素受体拮抗剂治疗反应的癌症患者的方法包括评价PAI-1,uPA,TGFβ2,IL-6,IL-8和OPG中的至​​少一种的表达水平 在患者组织样本中。 本发明的方法允许更有效地鉴定患者以接受内皮素受体拮抗剂治疗和确定患者对治疗的反应。