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    Bird vaccinating device and method of operation
    1.
    发明授权
    Bird vaccinating device and method of operation 有权
    鸟疫苗装置及其操作方法

    公开(公告)号：US06609479B2

    公开(公告)日：2003-08-26

    申请号：US10035341

    申请日：2002-01-04

    申请人： Richard Storer ,  Joe Dyer

    发明人： Richard Storer ,  Joe Dyer

    IPC分类号： A01K3700

    CPC分类号： A01K45/00 ,  A61D1/025

    摘要： The bird vaccinating device comprises a frame, a drum or carosel rotatable on a vertical axis or this frame, schackle means for attaching birds, and being angularly spaced on said drum, motor means to rotate said drum, to present the bird successively to different operating stations, wherein said drum has a polygonal shape, preferably octagonal, each lateral side of the polygon providing a flat surface, said schackle means protruding from said surface so that an attached bird can be backed on to this flat surface by the vaccinator for proper vaccination. Preferably means are provided to cause the drum to stop if grasped by a vaccinator and to release automatically the vaccinated bird, preferably on a slide, as well as to count the vaccinated birds.

    摘要翻译： 禽鸟疫苗装置包括可在垂直轴线或该框架上旋转的框架，滚筒或carosel，用于附接鸟类的钩形装置，并且在所述滚筒上成角度地间隔开，马达装置使所述滚筒旋转，将鸟类连续呈现不同的操作 站，其中所述滚筒具有多边形形状，优选八边形，多边形的每个侧面提供平坦表面，所述分支装置从所述表面突出，使得附接的鸟可以由所述接触器支撑到所述平坦表面上以进行适当的接种 。 优选地，提供用于使鼓停止的装置，如果由接种者抓住并且自动释放接种疫苗的鸟，优选在载玻片上释放，以及计数接种疫苗的鸟。

    2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
    6.
    发明授权
    2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections 有权
    2'和3'-核苷前药用于治疗黄病毒科感染

    公开(公告)号：US07625875B2

    公开(公告)日：2009-12-01

    申请号：US11005444

    申请日：2004-12-06

    申请人： Gilles Gosselin ,  Richard Storer ,  Paola LaColla ,  Jean-Pierre Sommadossi

    发明人： Gilles Gosselin ,  Richard Storer ,  Paola LaColla ,  Jean-Pierre Sommadossi

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： C07K9/003 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/00 ,  A61K45/06 ,  C07H19/06 ,  C07H19/067 ,  A61K2300/00

    摘要： 2′ and 3′-Prodrugs of 1′, 2′, 3′ or 4′-branched β-D or β-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

    摘要翻译： 描述了1'，2'，3'或4'-支链β-D或β-L核苷的2'和3'-前药，或其药学上可接受的盐和衍生物，其可用于预防和治疗黄病毒科 感染等相关条件。 这些修饰的核苷对黄病毒和瘟病毒提供了优异的结果，包括丙型肝炎病毒和通常通过RNA依赖性RNA逆转录酶复制的病毒。 提供化合物，组合物，方法和用途用于治疗包括HCV感染在内的黄病毒科感染，包括施用有效量的本发明前药或其药学上可接受的盐或衍生物。 这些药物可以任选地与另外的抗病毒剂组合或改变来施用，以预防或治疗黄病毒科感染和其他相关病症。