公开(公告)号：US07238692B2

公开(公告)日：2007-07-03

申请号：US10951120

申请日：2004-09-27

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krisha Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krisha Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

IPC分类号： A61M31/00 ,  A61F2/86 ,  C07D251/70 ,  C07D251/52 ,  C07D251/30

CPC分类号： A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/54 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

摘要翻译： 本发明涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法和组合物。 特别地，本发明涉及抑制或阻断糖基化蛋白质产生内皮细胞中信号传导相关炎症反应诱导的化合物。 本发明涉及抑制平滑肌增殖的化合物。 特别地，本发明涉及通过调节HSPG例如Perlecan抑制平滑肌细胞增殖的化合物。 本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞症状，例如再狭窄和动脉粥样硬化。