公开(公告)号：US07274769B2

公开(公告)日：2007-09-25

申请号：US11064357

申请日：2005-02-22

申请人： Robert A. Nordmeyer ,  Gyorgy P. Snell ,  Earl W. Cornell ,  William F. Kolbe ,  Derek T. Yegian ,  Thomas N. Earnest ,  Joseph M. Jaklevich ,  Carl W. Cork ,  Bernard D. Santarsiero ,  Raymond C. Stevens

发明人： Robert A. Nordmeyer ,  Gyorgy P. Snell ,  Earl W. Cornell ,  William F. Kolbe ,  Derek T. Yegian ,  Thomas N. Earnest ,  Joseph M. Jaklevich ,  Carl W. Cork ,  Bernard D. Santarsiero ,  Raymond C. Stevens

IPC分类号： G01N23/20

CPC分类号： G01N23/20025 ,  B01L9/065 ,  B01L2200/18 ,  B01L2300/1883 ,  C30B29/58 ,  C30B33/00 ,  C30B35/005 ,  G01N1/42 ,  G01N23/207

摘要： A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

摘要翻译： 用于运输，远程和无人值守安装的方法和装置，以及用于同步加速器产生的x射线衍射分析的蛋白质晶体的视觉对准和监测。 蛋白质样品始终保持在液氮温度：装运期间，安装，安装，对准，数据采集和拆卸之后。 样品必须在空间的某一点处另外稳定地对准至几微米。 远程和自动地准确执行这些任务的能力导致大量蛋白质表征工作的样品通量和可靠性的显着增加。 由于将蛋白质样品放置在每个容纳多个样品的样品盒的运输兼容层叠堆叠中，因此大量样品可以在单个低温运输容器中运输。