公开(公告)号：US5132300A

公开(公告)日：1992-07-21

申请号：US359548

申请日：1989-06-01

申请人： Robert A. Volkmann ,  V. John Jasys ,  Michael S. Kellogg

发明人： Robert A. Volkmann ,  V. John Jasys ,  Michael S. Kellogg

IPC分类号： C12N9/99 ,  A61K31/425 ,  A61K31/43 ,  A61P11/00 ,  A61P11/16 ,  A61P29/00 ,  A61P43/00 ,  C07D499/86 ,  C07D499/87 ,  C07D499/88 ,  C07D499/897 ,  C07D513/04

CPC分类号： C07D513/04 ,  C07D499/88

摘要： Novel beta lactam compounds having potent elastrase inhibition activity are disclosed. These compounds are characterized by the general structural formulae I, II, and III: ##STR1## These compounds are further characterized such that X and Y are each --S-- or --CH.sub.2 --, with at least one of X and Y being --S--, or alternatively, X is --SO-- or --SO.sub.2 -- and Y is --CH.sub.2 --; R.sup.1 is hydrogen, tri(lower alkyl)silyl, --COOR" or --CONHR"', wherein R" and R"' are each lower alkyl or phenyl(lower alkyl), and may be the same or different; R.sup.3 is hydrogen, lower alkyl or (lower alkyl)oxy; one of B and D is (lower alkyl)oxycarbonyl, (lower alkenyl)oxycarbonyl, allyloxycarbonyl or phenyl(lower alkyl)oxycarbonyl; and the other of B and D is hydrogen or lower alkyl.The compounds are useful as anti-inflammatory agents, particularly in the treatment of adult respiratory distress syndrome and rheumatoid arthritis.

公开(公告)号：US06858744B2

公开(公告)日：2005-02-22

申请号：US10431276

申请日：2003-05-07

申请人： John C. Kath ,  Zhengong B. Li ,  V. John Jasys ,  Frank J. Urban

发明人： John C. Kath ,  Zhengong B. Li ,  V. John Jasys ,  Frank J. Urban

IPC分类号： C07D241/44 ,  C07D307/33 ,  C07D405/12 ,  C07D201/44

CPC分类号： C07D307/33 ,  C07D241/44 ,  C07D405/12 ,  Y02P20/55

摘要： This invention relates to dihydroxyhexanoic acid derivatives and their intermediates, as well as to methods of preparing such compounds. Additionally, present invention relates to removing a protecting group from a protected amine wherein the method comprises reacting the protected amine with phosphoric acid.

摘要翻译： 本发明涉及二羟基己酸衍生物及其中间体，以及制备这些化合物的方法。 另外，本发明涉及从受保护的胺中除去保护基团，其中所述方法包括使被保护的胺与磷酸反应。