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公开(公告)号:US06350431B1
公开(公告)日:2002-02-26
申请号:US09429347
申请日:1999-10-28
申请人: Robert Allen Snow , Paul Mark Henrichs , Daniel Joseph Delecki , William Anthony Sanderson , Vinay Chandrakant Desai , Edward Bacon , Kenneth Robert Hollister , Eric Paul Hohenschuh
发明人: Robert Allen Snow , Paul Mark Henrichs , Daniel Joseph Delecki , William Anthony Sanderson , Vinay Chandrakant Desai , Edward Bacon , Kenneth Robert Hollister , Eric Paul Hohenschuh
IPC分类号: A61K4900
CPC分类号: A61K49/0054 , A61K41/0033 , A61K41/0057 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0036 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K49/006 , A61K49/0409 , A61K49/0433 , A61K49/0466 , A61K49/085 , A61K49/126
摘要: This invention provides a physiologically tolerable light imaging contrast agent compound having a molecular weight in the range 500 to 5000000 and containing at least two chromophores having delocalized electron systems as well as at least one polyalkylene oxide (PAO) moiety having a molecular weight in the range 60 to 100000.
摘要翻译: 本发明提供一种具有分子量在500至5000000范围内并含有至少两个具有离域电子系统的发色团以及至少一种分子量在该范围内的聚环氧烷(PAO)部分的生理可耐受的光成像造影剂化合物 60到100000。
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公开(公告)号:US06498945B1
公开(公告)日:2002-12-24
申请号:US09435616
申请日:1999-11-08
申请人: Jan Alan Alfheim , Paul Mark Henrichs , Eric Paul Hohenschuh , Edvin Wilheim Johannesen , William Anthony Sanderson , Robert Allen Snow
发明人: Jan Alan Alfheim , Paul Mark Henrichs , Eric Paul Hohenschuh , Edvin Wilheim Johannesen , William Anthony Sanderson , Robert Allen Snow
IPC分类号: A61B500
CPC分类号: A61K41/0033 , A61K47/60
摘要: A method of treatment of a human or animal body by sonodynamic therapy in which a sensitizer agent is administered to the body and the body is exposed to ultrasound to achieve a cytopathogenic effect at a site therein, wherein the said sensitizer agent is a physiologically tolerable substance which is capable of enhancing the cytopathogenic efficacy of said sonodynamic therapy. Preferably, the sensitizer agent is a water-soluble polymer compound or a conjugate thereof.
摘要翻译: 一种通过声动力学疗法治疗人或动物体的方法,其中将致敏剂施用于身体,并且身体暴露于超声波以在其中的部位达到细胞致病作用,其中所述敏化剂是生理上可耐受的物质 其能够增强所述声波动力疗法的细胞致病作用。 优选地,敏化剂是水溶性高分子化合物或其共轭物。
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