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1.发明授权Methods of eliciting an antibody response using flea protease proteins and homologs thereof 失效使用跳蚤蛋白酶蛋白及其同源物引起抗体应答的方法
公开(公告)号：US6139840A
公开(公告)日：2000-10-31
申请号：US817795
申请日：1997-08-01
CPC分类号： C12N9/6424 , C07K16/40 , C12N9/48 , C12N9/6472 , A61K35/00
摘要： The present invention relates to flea serine protease and aminopeptidase proteins; to flea serine protease and aminopeptidase nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or aminopeptdiase activities. The present invention also includes methods to obtain such proteins, nucleic acid moelcules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译： PCT No.PCT / US95 / 14442 Sec。 371日期：1997年8月1日 102（e）日期1997年8月1日PCT提交1995年10月18日PCT公布。 公开号WO96 / 11706 日期1996年04月25日本发明涉及跳蚤丝氨酸蛋白酶和氨基肽酶蛋白质; 跳蚤丝氨酸蛋白酶和氨基肽酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶和/或氨基肽酶活性的化合物。 本发明还包括获得这样的蛋白质，核酸moelcules，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。
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公开(公告)号：US6121035A
公开(公告)日：2000-09-19
申请号：US906616
申请日：1997-08-05
IPC分类号： A61K35/00 , A61K39/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N5/02 , C12N9/48 , C12N9/64 , C12N15/12 , A61K38/48
CPC分类号： C07K14/4359 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/6408 , C12N9/641 , C12N9/6424 , C12N9/6472 , A61K35/00 , A61K39/00
摘要： The present invention relates to flea serine protease proteins, aminopeptidase proteins and flea cysteine protease proteins; to flea serine protease, aminopeptidase and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease, aminopeptidase and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶蛋白，氨基肽酶蛋白和跳蚤半胱氨酸蛋白酶蛋白; 跳蚤丝氨酸蛋白酶，氨基肽酶和半胱氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶，氨基肽酶和/或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。
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公开(公告)号：US6150125A
公开(公告)日：2000-11-21
申请号：US639075
申请日：1996-04-24
申请人： Robert B. Grieve , Keith E. Rushlow , Shirley Wu Hunter , Glenn R. Frank , Gary L. Stiegler , Patrick J. Gaines , Gary Silver
发明人： Robert B. Grieve , Keith E. Rushlow , Shirley Wu Hunter , Glenn R. Frank , Gary L. Stiegler , Patrick J. Gaines , Gary Silver
IPC分类号： A61K35/00 , A61K38/00 , A61K39/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K16/40 , C12N5/02 , C12N9/48 , C12N9/64 , C12N15/12 , C12Q1/37 , C12N9/50
CPC分类号： C12N9/6408 , C07K14/4359 , C07K14/4742 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/641 , C12N9/6424 , C12N9/6472 , A61K35/00 , A61K38/00 , A61K39/00
摘要： The present invention relates to flea serine protease proteins, aminopeptidase proteins and flea cysteine protease proteins; to flea serine protease, aminopeptidase and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease, aminopeptidase and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶蛋白，氨基肽酶蛋白和跳蚤半胱氨酸蛋白酶蛋白; 跳蚤丝氨酸蛋白酶，氨基肽酶和半胱氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶，氨基肽酶和/或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。
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公开(公告)号：US06232096B1
公开(公告)日：2001-05-15
申请号：US08906613
申请日：1997-08-05
申请人： Robert B. Grieve , Keith E. Rushlow , Shirley Wu Hunter , Glenn R. Frank , Gary L. Stiegler , Patrick J. Gaines , Gary Silver
发明人： Robert B. Grieve , Keith E. Rushlow , Shirley Wu Hunter , Glenn R. Frank , Gary L. Stiegler , Patrick J. Gaines , Gary Silver
IPC分类号： C12N1512
CPC分类号： C12N9/6408 , A61K35/00 , A61K38/00 , A61K39/00 , C07K14/4359 , C07K14/4742 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/641 , C12N9/6424 , C12N9/6472
摘要： The present invention relates to flea serine protease proteins, aminopeptidase proteins and flea cysteine protease proteins; to flea serine protease, aminopeptidase and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease, aminopeptidase and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶蛋白，氨基肽酶蛋白和跳蚤半胱氨酸蛋白酶蛋白; 跳蚤丝氨酸蛋白酶，氨基肽酶和半胱氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶，氨基肽酶和/或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。
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公开(公告)号：US5712143A
公开(公告)日：1998-01-27
申请号：US485455
申请日：1995-06-07
IPC分类号： A61K35/00 , A61K39/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/64 , C12N15/12 , C12P21/08 , C07K1/40
CPC分类号： C07K14/4359 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/6408 , C12N9/641 , C12N9/6424 , C12N9/6472 , A61K35/00 , A61K39/00 , Y10S514/83
摘要： The present invention relates to flea serine protease and aminopeptidase proteins; to flea serine protease and aminopeptidase nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or aminopeptidase activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶和氨基肽酶蛋白质; 跳蚤丝氨酸蛋白酶和氨基肽酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶和/或氨基肽酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。
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公开(公告)号：US06214579B1
公开(公告)日：2001-04-10
申请号：US09012692
申请日：1998-01-23
IPC分类号： C12N1512
CPC分类号： C12N9/6408 , A61K35/00 , A61K39/00 , C07K16/40 , C12N9/48 , C12N9/641 , C12N9/6424 , C12N9/6472
摘要： The present invention relates to flea serine protease proteins, aminopeptidase proteins and flea cysteine protease proteins; to flea serine protease, aminopeptidase and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease, aminopeptidase and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶蛋白，氨基肽酶蛋白和跳蚤半胱氨酸蛋白酶蛋白; 跳蚤丝氨酸蛋白酶，氨基肽酶和半胱氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶，氨基肽酶和/或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。
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公开(公告)号：US06180383B2
公开(公告)日：2001-01-30
申请号：US09012431
申请日：1998-01-23
IPC分类号： C12N948
CPC分类号： C12N9/6408 , A61K35/00 , A61K38/00 , A61K39/00 , C07K14/4359 , C07K14/4742 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/641 , C12N9/6424 , C12N9/6472
摘要： The present invention relates to flea serine protease proteins, aminopeptidase proteins and flea cysteine protease proteins; to flea serine protease, aminopeptidase and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease, aminopeptidase and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶蛋白，氨基肽酶蛋白和跳蚤半胱氨酸蛋白酶蛋白; 跳蚤丝氨酸蛋白酶，氨基肽酶和半胱氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶，氨基肽酶和/或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。
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公开(公告)号：US6077687A
公开(公告)日：2000-06-20
申请号：US906769
申请日：1997-08-05
申请人： Robert B. Grieve , Keith E. Rushlow , Shirley Wu Hunter , Glenn R. Frank , Gary L. Stiegler , Patrick J. Gaines
发明人： Robert B. Grieve , Keith E. Rushlow , Shirley Wu Hunter , Glenn R. Frank , Gary L. Stiegler , Patrick J. Gaines
IPC分类号： A61K35/00 , A61K38/00 , A61K39/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K16/40 , C12N5/02 , C12N9/48 , C12N9/64 , C12N15/12 , C12N15/52 , C12N7/01 , C12N15/57
CPC分类号： C12N9/6408 , C07K14/4359 , C07K14/4742 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/641 , C12N9/6424 , C12N9/6472 , A61K35/00 , A61K38/00 , A61K39/00
摘要： The present invention relates to flea serine protease proteins, aminopeptidase proteins and flea cysteine protease proteins; to flea serine protease, aminopeptidase and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease, aminopeptidase and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶蛋白，氨基肽酶蛋白和跳蚤半胱氨酸蛋白酶蛋白; 跳蚤丝氨酸蛋白酶，氨基肽酶和半胱氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶，氨基肽酶和/或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。
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公开(公告)号：US5972645A
公开(公告)日：1999-10-26
申请号：US484211
申请日：1995-06-07
IPC分类号： A61K35/00 , A61K39/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/64 , C12N15/12 , C12P21/08 , C12N15/52
CPC分类号： C07K14/4359 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/6408 , C12N9/641 , C12N9/6424 , C12N9/6472 , A61K35/00 , A61K39/00
摘要： The present invention relates to flea serine protease and aminopeptidase proteins; to flea serine protease and aminopeptidase nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or aminopeptidase activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶和氨基肽酶蛋白质; 跳蚤丝氨酸蛋白酶和氨基肽酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶和/或氨基肽酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。
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公开(公告)号：US6146870A
公开(公告)日：2000-11-14
申请号：US485443
申请日：1995-06-07
IPC分类号： A61K35/00 , A61K39/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/64 , C12N15/12 , C12P21/08 , C12N9/50
CPC分类号： C07K14/4359 , C07K16/18 , C07K16/40 , C12N9/48 , C12N9/6408 , C12N9/641 , C12N9/6424 , C12N9/6472 , A61K35/00 , A61K39/00
摘要： The present invention relates to flea serine protease and aminopeptidase proteins; to flea serine protease and aminopeptidase nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or aminopeptidase activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶和氨基肽酶蛋白质; 跳蚤丝氨酸蛋白酶和氨基肽酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶和/或氨基肽酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。
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