利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

67 条记录 (耗时 0.05 秒)

    Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof
    1.
    发明授权
    Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof 有权
    跳蚤头，神经线，后肠和恶臭小管核酸分子，蛋白质及其用途

    公开(公告)号：US08088903B2

    公开(公告)日：2012-01-03

    申请号：US11565729

    申请日：2006-12-01

    申请人： Kevin S. Brandt ,  Patrick J. Gaines ,  Dan T. Stinchcomb ,  Nancy Wisnewski

    发明人： Kevin S. Brandt ,  Patrick J. Gaines ,  Dan T. Stinchcomb ,  Nancy Wisnewski

    IPC分类号： C07H21/02 ,  C07H21/04

    CPC分类号： C07K14/4359

    摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, antibodies, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.

    摘要翻译： 本发明涉及跳蚤头，神经根，后肠和马鞭状小管蛋白; 跳蚤头，神经线，后肠和马鞭状小管核酸分子，包括编码这种跳蚤头，神经线，后肠和马鞭状小管蛋白的那些; 针对这种跳蚤头，神经线，后肠和马鞭状小管蛋白质产生的抗体; 以及抑制跳蚤头，神经丝，后肠和马鞭状小管蛋白活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含衍生自本发明蛋白质的蛋白质，核酸分子，抗体或保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。 本发明还包括使用跳蚤头，神经根，后肠和马鞭状小管蛋白来衍生抑制性化合物。

    Flea ultraspiracle nucleic acid molecules
    2.
    发明授权
    Flea ultraspiracle nucleic acid molecules 失效
    跳蚤超尖锐核酸分子

    公开(公告)号：US07667019B2

    公开(公告)日：2010-02-23

    申请号：US11697551

    申请日：2007-04-06

    申请人： Nancy Wisnewski ,  Anna M. Becher ,  Eric Jarvis

    发明人： Nancy Wisnewski ,  Anna M. Becher ,  Eric Jarvis

    IPC分类号： C07H21/04 ,  A61K38/00

    CPC分类号： C07K14/4359 ,  C07K14/721 ,  Y10S530/858

    摘要： The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.

    摘要翻译： 本发明涉及跳蚤蜕皮激素受体和超尖锐蛋白质; 跳蚤蜕皮激素受体和超尖锐核酸分子，包括那些编码这种跳蚤蜕皮激素受体和超尖锐蛋白质的分子; 针对这种跳蚤蜕皮激素受体和超尖锐蛋白的抗体; 以及抑制跳蚤蜕皮激素受体和/或超急性活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含抑制蜕皮激素受体和蜕皮激素之间结合的本发明蛋白质的保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。

    Ectoparasite saliva proteins and apparatus to collect such proteins
    5.
    发明授权
    Ectoparasite saliva proteins and apparatus to collect such proteins 失效
    外寄生唾液蛋白质和收集这些蛋白质的装置

    公开(公告)号：US06485968B1

    公开(公告)日：2002-11-26

    申请号：US09004730

    申请日：1998-01-08

    申请人： Eric R. Weber ,  Shirley Wu Hunter ,  Gek-Kee Sim ,  Glenn Robert Frank ,  Lynda Wallenfels

    发明人： Eric R. Weber ,  Shirley Wu Hunter ,  Gek-Kee Sim ,  Glenn Robert Frank ,  Lynda Wallenfels

    IPC分类号： C12N1512

    CPC分类号： G01N1/24 ,  A61K38/00 ,  A61K39/00 ,  C07K14/43563 ,  C07K14/4359 ,  C07K16/18

    摘要： The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention also relates to ectoparasite saliva proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to obtain such proteins and to use such proteins to identify animals susceptible to or having allergic dermatitis. The present invention also includes therapeutic compositions comprising such proteins and their use to treat animals susceptible to or having allergic dermatitis.

    摘要翻译： 本发明涉及一种用于分离异位唾液蛋白的新产品和方法，以及用于在动物中检测和/或治疗过敏性皮炎的新产品和方法。 本发明还涉及外寄生物唾液蛋白质，具有编码这种蛋白质的序列的核酸分子和针对这种蛋白质产生的抗体。 本发明还包括获得这种蛋白质和使用这些蛋白质鉴定易感或具有过敏性皮炎的动物的方法。 本发明还包括包含这些蛋白质的治疗组合物及其用于治疗易感或具有过敏性皮炎的动物的用途。

    DNA molecules encoding Ctenocephalides felis glutamate gated chloride channels
    6.
    发明授权
    DNA molecules encoding Ctenocephalides felis glutamate gated chloride channels 失效
    编码Ctenocephalides felis glutamate门控氯化物通道的DNA分子

    公开(公告)号：US06358701B1

    公开(公告)日：2002-03-19

    申请号：US09130339

    申请日：1998-08-06

    申请人： Jeffrey W. Warmke ,  Doris F. Cully ,  Adrian Etter ,  Philip S. Paress ,  Charles J. Cohen ,  Richard Brochu

    发明人： Jeffrey W. Warmke ,  Doris F. Cully ,  Adrian Etter ,  Philip S. Paress ,  Charles J. Cohen ,  Richard Brochu

    IPC分类号： C07H2104

    CPC分类号： C07K14/4359 ,  C07K14/70571

    摘要： To date, L-glutamate-gated chloride (GluCl) channels have been observed only in invertebrate organisms. Modulators of this channel (either agonists or antagoinists) will interfere with neurotransmission. For example, agents such as avermectins activate the GluCl, causing paralysis due to blocking of neurotranmitter release, resulting in death of the organism. Because GluCl channels are invertebreate specific, they are excellent targets for the discovery of novel insecticides, anthelminths and parasiticides that will display a marked safety profile because of the lack of mechanism based toxicity in vertebrate organisms. The present specification discloses isolation of a cDNA clone from the cat flea Ctenocephalides felis (CfGluCl-1) that encodes a L-glutamate-gated chloride channel. Heterologous expression of CfGluCl-1 cRNA in Xenopus oocytes results in robust expression of a L-glutamate-gated chloride current and the channel is activated and potentiated by avermectins. The expression of CfGluCl-1 in a heterologous expression system if useful to screens for novel GluCl channel agonsts and antagonsits. Additionally, this specification disclose impoved methods of screening for GluCl channel modulators.

    摘要翻译： 迄今为止，仅在无脊椎动物体内观察到L-谷氨酸氯化物（GluCl）通道。 该通道的调节剂（激动剂或antagoinists）将干扰神经传递。 例如，除虫菌素之类的试剂激活GluCl，由于神经递质释放的阻断导致麻痹，导致生物体的死亡。 由于GluCl通道具有特异性，因此它们是发现新型杀虫剂，anthelminths和杀寄生虫剂的优秀目标，由于脊椎动物体内缺乏基于机制的毒性，因此将显示出明显的安全性。 本说明书公开了从编码L-谷氨酸盐化氯化物通道的猫蚤Ctenocephalides felis（CfGluCl-1）中分离cDNA克隆。 非洲爪蟾卵母细胞中CfGluCl-1 cRNA的异源表达导致L-谷氨酸氯化物电流的强烈表达，并且通道被阿凡曼菌素激活和增强。 CfGluCl-1在异源表达系统中的表达如果可用于筛选新的GluCl通道激动剂和antagonsits。 另外，本说明书公开了筛选GluCl通道调节剂的方法。

    Ectoparasite histamine releasing factor, genes and uses thereof
    8.
    发明授权
    Ectoparasite histamine releasing factor, genes and uses thereof 失效
    外寄生物组胺释放因子，基因及其用途

    公开(公告)号：US6063902A

    公开(公告)日：2000-05-16

    申请号：US4053

    申请日：1998-01-07

    申请人： Gary L. Stiegler

    发明人： Gary L. Stiegler

    IPC分类号： A61K38/00 ,  C07K14/435 ,  C12N1/21 ,  C12N15/12 ,  C07K1/00 ,  A61K39/00 ,  C07K16/00 ,  A61K14/00

    CPC分类号： C07K14/4359 ,  C07K14/43563 ,  A61K38/00 ,  Y10S530/858

    摘要： The present invention relates to ectoparasite histamine releasing factor (HRF) proteins; to ectoparasite HRF nucleic acid molecules, including those that encode such HRF proteins; to antibodies raised against such HRF proteins; and to compounds that inhibit ectoparasite HRF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to reduce ectoparasite burden of animals.

    摘要翻译： 本发明涉及外寄生物组胺释放因子（HRF）蛋白; 到外寄生物HRF核酸分子，包括编码这种HRF蛋白的那些; 针对这种HRF蛋白产生的抗体; 以及抑制外寄生物HRF活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及使用这种治疗组合物来减少动物的外寄生物负担。