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公开(公告)号：US06573246B1
公开(公告)日：2003-06-03
申请号：US09644470
申请日：2000-08-23
IPC分类号： A61K3170
CPC分类号： C07H15/04
摘要： This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage, 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.
摘要翻译： 本发明提供脂质，其具有：1）甘油骨架; 2）优选饱和并含有16或18个碳原子的烃链，其通过醚键连接到主链的C-1上，3）连接于主链C-2上的甲基，优选通过醚键; 和4）以α或β端基构型连接在甘油骨架的C-3上的糖，通过其一个或多个羟基的修饰或取代来改变糖。 本文还提供了含醚 - 脂质的组合物，以及将这些组合物施用于动物，例如患有癌症的那些以及各种其它疾病和病症的方法。
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公开(公告)号：US6153736A
公开(公告)日：2000-11-28
申请号：US722881
申请日：1996-09-26
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7028 , A61P29/00 , A61P31/00 , A61P35/00 , C07H15/04 , C07H15/10 , C07H15/14 , C07H15/06 , C07H5/06
CPC分类号： C07H15/04
摘要： This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage; 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.
摘要翻译： 本发明提供脂质，其具有：1）甘油骨架; 2）优选饱和并含有16或18个碳原子的烃链，其通过醚键与骨架的C-1连接; 3）优选通过醚键连接至主链C-2上的甲基; 和4）以α或β端基构型连接在甘油骨架的C-3上的糖，通过其一个或多个羟基的修饰或取代来改变糖。 本文还提供了含醚 - 脂质的组合物，以及将这些组合物施用于动物，例如患有癌症的那些以及各种其它疾病和病症的方法。
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公开(公告)号：USD371906S
公开(公告)日：1996-07-23
申请号：US27854
申请日：1994-07-25
申请人： Andrew C. Peters
设计人： Andrew C. Peters
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4.发明申请MAGNETIC BUCKLE ASSEMBLIES AND ASSOCIATED METHODS FOR USE WITH CHILD SEATS AND OTHER RESTRAINT SYSTEMS 审中-公开用于儿童座椅和其他限制系统的磁扣组件及相关方法公开(公告)号：US20120080917A1
公开(公告)日：2012-04-05
申请号：US13233835
申请日：2011-09-15
申请人： Peter E. Miller , Ian J. Hadlow , Derrick J. Barker , Andrew C. Peters , Sean L. Casey , Phillip Morgan , Alphons L. Van Der Mullen
发明人： Peter E. Miller , Ian J. Hadlow , Derrick J. Barker , Andrew C. Peters , Sean L. Casey , Phillip Morgan , Alphons L. Van Der Mullen
CPC分类号： B60N2/2812 , B60N2002/2815 , Y10T24/32 , Y10T29/49826
摘要： Magnetic buckle assemblies and associated methods of use with child seats and other restraint systems are disclosed herein. A restraint system configured in accordance with one embodiment of the present disclosure includes a first web connector and a second web connector configured to releasably engage the first web connector. The restraint system can further include a magnet positioned on at least one of the first and second web connectors. The magnet can be configured to hold the first and second web connectors together such that they can be simultaneously inserted into a corresponding buckle.
摘要翻译： 本文公开了磁扣组件及其与儿童座椅和其他约束系统的相关联的使用方法。 根据本公开的一个实施例配置的约束系统包括构造成可释放地接合第一腹板连接器的第一腹板连接器和第二腹板连接器。 约束系统还可以包括位于第一和第二网状连接器中的至少一个上的磁体。 磁体可以被配置为将第一和第二网状连接器保持在一起，使得它们可以同时插入到相应的带扣中。
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公开(公告)号：US5017035A
公开(公告)日：1991-05-21
申请号：US219720
申请日：1988-07-15
IPC分类号： B43K5/14
CPC分类号： B43K5/14
摘要： A cartridge refill pen is provided with a cartridge refill cavity which allows a cartridge to be laterally loaded into the pan. The cavity is opened and closed on relative rotational movement of interconnected generally tubular parts of the pen.
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