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    Modified ether glyceroglycolipids
    1.
    发明授权
    Modified ether glyceroglycolipids 失效
    改性醚甘油糖脂

    公开(公告)号：US06573246B1

    公开(公告)日：2003-06-03

    申请号：US09644470

    申请日：2000-08-23

    申请人： Robert Bittman ,  Ravi K. Erukulla ,  Andrew C. Peters ,  Eric G. Mayhew

    发明人： Robert Bittman ,  Ravi K. Erukulla ,  Andrew C. Peters ,  Eric G. Mayhew

    IPC分类号： A61K3170

    CPC分类号： C07H15/04

    摘要： This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage, 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.

    摘要翻译： 本发明提供脂质，其具有：1）甘油骨架; 2）优选饱和并含有16或18个碳原子的烃链，其通过醚键连接到主链的C-1上，3）连接于主链C-2上的甲基，优选通过醚键; 和4）以α或β端基构型连接在甘油骨架的C-3上的糖，通过其一个或多个羟基的修饰或取代来改变糖。 本文还提供了含醚 - 脂质的组合物，以及将这些组合物施用于动物，例如患有癌症的那些以及各种其它疾病和病症的方法。

    Modified ether glyceroglycolipids
    2.
    发明授权
    Modified ether glyceroglycolipids 失效
    改性醚甘油糖脂

    公开(公告)号：US6153736A

    公开(公告)日：2000-11-28

    申请号：US722881

    申请日：1996-09-26

    申请人： Robert Bittman ,  Ravi K. Erukulla ,  Andrew C. Peters ,  Eric G. Mayhew

    发明人： Robert Bittman ,  Ravi K. Erukulla ,  Andrew C. Peters ,  Eric G. Mayhew

    IPC分类号： A61K31/00 ,  A61K31/70 ,  A61K31/7028 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  C07H15/04 ,  C07H15/10 ,  C07H15/14 ,  C07H15/06 ,  C07H5/06

    CPC分类号： C07H15/04

    摘要： This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage; 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.

    摘要翻译： 本发明提供脂质，其具有：1）甘油骨架; 2）优选饱和并含有16或18个碳原子的烃链，其通过醚键与骨架的C-1连接; 3）优选通过醚键连接至主链C-2上的甲基; 和4）以α或β端基构型连接在甘油骨架的C-3上的糖，通过其一个或多个羟基的修饰或取代来改变糖。 本文还提供了含醚 - 脂质的组合物，以及将这些组合物施用于动物，例如患有癌症的那些以及各种其它疾病和病症的方法。