N9 morpholino derivatives of 7,8-disubstituted guanines
    1.
    发明授权
    N9 morpholino derivatives of 7,8-disubstituted guanines 失效
    7,8二取代鸟嘌呤的N9吗啉衍生物

    公开(公告)号:US5382580A

    公开(公告)日:1995-01-17

    申请号:US250484

    申请日:1994-05-27

    IPC分类号: C07D473/18 A61K31/535

    CPC分类号: C07D473/18

    摘要: Immunostimulating 7,8-disubstituted guanine derivatives that also contain a morpholinyl group as a position-9 substituent are disclosed whose structures are represented by formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl group having a length of about one to about seven carbon atoms; R.sup.2 is a hydrogen or C.sub.1 -C.sub.8 acyl; R.sup.3 is hydrogen, a C.sub.1 -C.sub.5 aliphatic hydrocarbyl, aralkyl or substituted aralkyl group; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating substituted guanine derivative and processes for using the same.

    摘要翻译: 公开了其还含有吗啉基作为位置-9取代基的7,8-二取代的鸟嘌呤衍生物,其结构由式I其中X是O或S表示; R1是长度为约1至约7个碳原子的烃基或取代的烃基; R2是氢或C1-C8酰基; R3是氢,C1-C5脂族烃基,芳烷基或取代的芳烷基; 及其药学上可接受的碱加成盐。 还公开了含有免疫刺激性取代的鸟嘌呤衍生物的组合物及其使用方法。

    N.sup.9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines
    2.
    发明授权
    N.sup.9 alkyl or aralkyl derivatives of 7, 8-disubstituted guanines 失效
    7,8-二取代的guanines的N9烷基或芳烷基衍生物

    公开(公告)号:US5786359A

    公开(公告)日:1998-07-28

    申请号:US703578

    申请日:1996-08-27

    IPC分类号: C07D473/18 A61K31/52

    CPC分类号: C07D473/18

    摘要: Immunostimulating 7,8-disubstituted guanine derivatives that also contain a 9-alkyl, 9-alkoxy or 9-aralkyl substituent are disclosed whose structures are represented by Formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl group having a length of about one to about seven carbon atoms; R.sup.2 is a hydrocarbyl or hydroxyl- or ether-substituted hydrocarbyl group having a length of about four to about ten carbon atoms; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating guanine derivative and processes for using the same.

    摘要翻译: 公开了也含有9-烷基,9-烷氧基或9-芳烷基取代基的7,8-二取代鸟嘌呤衍生物的免疫刺激,其结构由式I其中X是O或S表示; R1是长度为约1至约7个碳原子的烃基或取代的烃基; R2是长度为约4至约10个碳原子的烃基或羟基或醚取代的烃基; 及其药学上可接受的碱加成盐。 还公开了含有免疫刺激性鸟嘌呤衍生物的组合物及其使用方法。

    Use of N9 morpholino derivatives of 7,8-disubstituted guanines
    3.
    发明授权
    Use of N9 morpholino derivatives of 7,8-disubstituted guanines 失效
    使用7,8-二取代鸟嘌呤的N9吗啉代衍生物

    公开(公告)号:US5439907A

    公开(公告)日:1995-08-08

    申请号:US373374

    申请日:1995-01-17

    IPC分类号: C07D473/18 A61K31/535

    CPC分类号: C07D473/18

    摘要: Immunostimulating 7,8-disubstituted guanine derivatives that also contain a morpholinyl group as a position-9 substituent are disclosed whose structures are represented by formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl group having a length of about one to about seven carbon atoms; R.sup.2 is a hydrogen or C.sub.1 -C.sub.8 acyl; R.sup.3 is hydrogen, a C.sub.1 -C.sub.5 aliphatic hydrocarbyl, aralkyl or substituted aralkyl group; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating substituted guanine derivative and processes for using the same.

    摘要翻译: 公开了其还含有吗啉基作为位置-9取代基的7,8-二取代的鸟嘌呤衍生物,其结构由式I其中X是O或S表示; R1是长度为约1至约7个碳原子的烃基或取代的烃基; R2是氢或C1-C8酰基; R3是氢,C1-C5脂族烃基,芳烷基或取代的芳烷基; 及其药学上可接受的碱加成盐。 还公开了含有免疫刺激性取代的鸟嘌呤衍生物的组合物及其使用方法。

    2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their
immunostimulative effect
    4.
    发明授权
    2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect 失效
    2'3'-二脱氧-2',3'-二脱氢-7,8-二取代鸟苷及其免疫刺激作用

    公开(公告)号:US5441942A

    公开(公告)日:1995-08-15

    申请号:US250483

    申请日:1994-05-27

    CPC分类号: C07H19/16

    摘要: Immunostimulating 7,8-disubstituted guanine derivatives that also contain a .beta.-9,1'-linked-2',3'-dideoxy-2',3'-didehydroribosyl substituent are disclosed whose structures are represented by Formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl moiety having a length of about one to about seven carbon atoms; R.sup.2 is hydrogen or C.sub.1 -C.sub.8 acyl; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating guanine derivative and processes for using the same.

    摘要翻译: 公开了免疫刺激还含有β-9,1'-连接-2',3'-二脱氧-2',3'-二脱氧山梨糖基取代基的7,8-二取代鸟嘌呤衍生物,其结构由式I表示 其中X是O或S; R1是具有约1至约7个碳原子长度的烃基或取代的烃基部分; R2是氢或C1-C8酰基; 及其药学上可接受的碱加成盐。 还公开了含有免疫刺激性鸟嘌呤衍生物的组合物及其使用方法。

    USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF DEPRESSION
    6.
    发明申请
    USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF DEPRESSION 审中-公开
    苯并呋喃磺酰胺衍生物用于治疗呕吐的应用

    公开(公告)号:US20070155827A1

    公开(公告)日:2007-07-05

    申请号:US11612249

    申请日:2006-12-18

    IPC分类号: A61K31/36 A61K31/353

    摘要: The present invention is a method for the treatment of depression comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined. The present invention is directed to a method for the treatment of depression, which includes mono-therapy and alternatively, co-therapy with at least one antidepressant.

    摘要翻译: 本发明是一种治疗抑郁症的方法,包括向有需要的受试者施用治疗有效量的如本文所定义的一种或多种式(I)和式(II)的新型苯并稠合的杂环磺酰胺衍生物。 本发明涉及一种治疗抑郁症的方法,其包括单一治疗,或者与至少一种抗抑郁药共同治疗。