公开(公告)号：US20100285490A1

公开(公告)日：2010-11-11

申请号：US11966747

申请日：2007-12-28

申请人： Robert Dees ,  Dale Dembrow ,  Brent Henry ,  Espir Kahatt ,  James Meegan ,  Timothy Powers ,  Steven Roman ,  Jeffrey Rossio

发明人： Robert Dees ,  Dale Dembrow ,  Brent Henry ,  Espir Kahatt ,  James Meegan ,  Timothy Powers ,  Steven Roman ,  Jeffrey Rossio

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N33/54373

摘要： The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users.

摘要翻译： 本发明部分涉及用于检测试剂的方法，试剂和装置。 本发明还部分涉及包括但不限于流动池，测定室，试剂储存器输送单元和用于保持测定室的装置的组合物。 本发明还提供了用于各种检测装置的各种部件和组件的组合。 本发明还涉及一种便携式检测装置，其可以在现场使用或在一个关注点处使用，并且不限于专门的实验室或被高技能用户使用。

公开(公告)号：US20120196304A1

公开(公告)日：2012-08-02

申请号：US13311519

申请日：2011-12-05

申请人： Robert DEES ,  Dale Dembrow ,  Brent Henry ,  Espir Kahatt ,  James Meegan ,  Timothy Powers ,  Steven Roman ,  Jeffrey Rossio

发明人： Robert DEES ,  Dale Dembrow ,  Brent Henry ,  Espir Kahatt ,  James Meegan ,  Timothy Powers ,  Steven Roman ,  Jeffrey Rossio

IPC分类号： G01N33/53 ,  C12M1/40

CPC分类号： G01N33/54373

摘要： The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users.

摘要翻译： 本发明部分涉及用于检测试剂的方法，试剂和装置。 本发明还部分涉及包括但不限于流动池，测定室，试剂储存器输送单元和用于保持测定室的装置的组合物。 本发明还提供了用于各种检测装置的各种部件和组件的组合。 本发明还涉及一种便携式检测装置，其可以在现场使用或在一个关注点处使用，并且不限于专门的实验室或被高技能用户使用。

公开(公告)号：US20120108452A1

公开(公告)日：2012-05-03

申请号：US13044496

申请日：2011-03-09

申请人： David Neujahr ,  Aminu Mohammed ,  Jeffrey Rossio

发明人： David Neujahr ,  Aminu Mohammed ,  Jeffrey Rossio

IPC分类号： C40B30/04 ,  G01N33/566

CPC分类号： G01N33/6893 ,  G01N33/6884 ,  G01N2333/521 ,  G01N2333/54 ,  G01N2333/5437 ,  G01N2800/12 ,  G01N2800/245

摘要： Described and disclosed are methods for determining, predicting, diagnosing, treating, and monitoring lung diseases, including bronchiolitis obliterans syndrome and acute cellular rejection in a lung transplant recipient by measuring chemokine levels in bronchoalveolar lavage (BAL) samples. The chemokine CXCL10 is measured in combination with at least one analyte selected from the group consisting of IL1RA, CXCL11, MCP-1, CXCL9, RANTES, IL-13, IL-17, IL-22, fractalkine, and eotaxin; and/or biomarkers. The present teachings also relate to methods, treatment decisions and kits for detecting and monitoring onset of lung transplant rejection in advance of clinically recognized symptoms.

摘要翻译： 描述和公开了通过测量支气管肺泡灌洗（BAL）样品中的趋化因子水平来确定，预测，诊断，治疗和监测肺部疾病的方法，包括闭塞性细支气管炎综合征和肺移植受体中的急性细胞排斥反应。 与至少一种选自IL1RA，CXCL11，MCP-1，CXCL9，RANTES，IL-13，IL-17，IL-22，fractalkine和嗜酸细胞活化趋化因子的分析物组合测量趋化因子CXCL10; 和/或生物标志物。 本教导还涉及在临床认可的症状之前检测和监测肺移植排斥发作的方法，治疗决定和试剂盒。