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公开(公告)号:US20070254913A1
公开(公告)日:2007-11-01
申请号:US11785741
申请日:2007-04-19
申请人: Robert Dunn , Eric Kuester , Richard Conticello , Allen Hopper
发明人: Robert Dunn , Eric Kuester , Richard Conticello , Allen Hopper
IPC分类号: A61K31/4745 , A61K31/4439 , A61K31/416 , A61K31/4152 , C07D403/02 , C07D405/02 , C07D471/02
CPC分类号: C07D403/04 , C07D231/56 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/12 , C07D407/14 , C07D471/04
摘要: Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
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公开(公告)号:US20070049611A1
公开(公告)日:2007-03-01
申请号:US11449868
申请日:2006-06-09
申请人: Francisco Talamas , Joan Caroon , Robert Dunn , Allen Hopper , Eric Kuester , Richard Schumacher , Ashok Tehim
发明人: Francisco Talamas , Joan Caroon , Robert Dunn , Allen Hopper , Eric Kuester , Richard Schumacher , Ashok Tehim
IPC分类号: A61K31/506 , A61K31/4439 , A61K31/4545 , C07D417/02 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号: C07D211/58 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, E, G, J, K, R1, R2, R3, R4, R11, R12, R13, R14, R21, R22, R23 and R24 are as defined herein.
摘要翻译: PDE4抑制通过新化合物,例如N-取代的二芳基胺类似物来实现。 本发明的化合物为式I-III:其中A,B,D,E,G,J,K,R 1,R 2, R 3,R 4,R 11,R 12,R 13,R 13, SEQ ID NO:14,R 21,R 22,R 23和R 24定义如上 这里。
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