-
公开(公告)号:US20070254913A1
公开(公告)日:2007-11-01
申请号:US11785741
申请日:2007-04-19
申请人: Robert Dunn , Eric Kuester , Richard Conticello , Allen Hopper
发明人: Robert Dunn , Eric Kuester , Richard Conticello , Allen Hopper
IPC分类号: A61K31/4745 , A61K31/4439 , A61K31/416 , A61K31/4152 , C07D403/02 , C07D405/02 , C07D471/02
CPC分类号: C07D403/04 , C07D231/56 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/12 , C07D407/14 , C07D471/04
摘要: Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
-
公开(公告)号:US07495017B2
公开(公告)日:2009-02-24
申请号:US11797151
申请日:2007-05-01
申请人: Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
发明人: Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
IPC分类号: A61K31/415 , A61K31/4439 , C07D231/12 , C07D401/04
CPC分类号: C07D403/04 , C07D231/12 , C07D231/56 , C07D307/20 , C07D405/04 , C07D405/12 , C07D409/12
摘要: Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
摘要翻译: 通过芳基和杂芳基吡唑化合物实现选择性PDE4抑制。 与化合物如咯利普兰相比,化合物表现出改善的PDE4抑制,并且在抑制其他类型的PDE时显示出选择性。
-
公开(公告)号:US20070203197A1
公开(公告)日:2007-08-30
申请号:US11797151
申请日:2007-05-01
申请人: Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
发明人: Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
IPC分类号: A61K31/4439 , A61K31/416 , A61K31/415 , C07D405/02 , C07D403/02
CPC分类号: C07D403/04 , C07D231/12 , C07D231/56 , C07D307/20 , C07D405/04 , C07D405/12 , C07D409/12
摘要: Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
-
公开(公告)号:US07226930B2
公开(公告)日:2007-06-05
申请号:US10825611
申请日:2004-04-16
申请人: Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
发明人: Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
IPC分类号: A61K31/437 , A61K31/4155 , C07D231/54 , C07D471/06
CPC分类号: C07D403/04 , C07D231/12 , C07D231/56 , C07D307/20 , C07D405/04 , C07D405/12 , C07D409/12
摘要: Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
摘要翻译: 通过芳基和杂芳基吡唑化合物实现选择性PDE4抑制。 与化合物如咯利普兰相比,化合物表现出改善的PDE4抑制,并且在抑制其他类型的PDE时显示出选择性。
-
公开(公告)号:US20060154960A1
公开(公告)日:2006-07-13
申请号:US11249769
申请日:2005-10-14
申请人: Allen Hopper , Robert Dunn , Erik Kuester , Richard Conticello
发明人: Allen Hopper , Robert Dunn , Erik Kuester , Richard Conticello
IPC分类号: A61K31/4745 , A61K31/4439 , C07D471/02 , C07D403/02
CPC分类号: C07D405/12 , C07D231/12 , C07D231/56 , C07D403/04 , C07D403/14 , C07D405/04
摘要: Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
-
公开(公告)号:US20090221661A1
公开(公告)日:2009-09-03
申请号:US12389873
申请日:2009-02-20
申请人: Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
发明人: Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
IPC分类号: A61K31/4155 , C07D405/10 , A61P25/18
CPC分类号: C07D403/04 , C07D231/12 , C07D231/56 , C07D307/20 , C07D405/04 , C07D405/12 , C07D409/12
摘要: Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
摘要翻译: 通过芳基和杂芳基吡唑化合物来实现选择性PDE4抑制。 与化合物如咯利普兰相比,化合物表现出改善的PDE4抑制,并且在抑制其他类型的PDE时显示出选择性。
-
公开(公告)号:US20070049611A1
公开(公告)日:2007-03-01
申请号:US11449868
申请日:2006-06-09
申请人: Francisco Talamas , Joan Caroon , Robert Dunn , Allen Hopper , Eric Kuester , Richard Schumacher , Ashok Tehim
发明人: Francisco Talamas , Joan Caroon , Robert Dunn , Allen Hopper , Eric Kuester , Richard Schumacher , Ashok Tehim
IPC分类号: A61K31/506 , A61K31/4439 , A61K31/4545 , C07D417/02 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号: C07D211/58 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: PDE4 inhibition is achieved by novel compounds, e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, E, G, J, K, R1, R2, R3, R4, R11, R12, R13, R14, R21, R22, R23 and R24 are as defined herein.
摘要翻译: PDE4抑制通过新化合物,例如N-取代的二芳基胺类似物来实现。 本发明的化合物为式I-III:其中A,B,D,E,G,J,K,R 1,R 2, R 3,R 4,R 11,R 12,R 13,R 13, SEQ ID NO:14,R 21,R 22,R 23和R 24定义如上 这里。
-
公开(公告)号:US20060135535A1
公开(公告)日:2006-06-22
申请号:US11253812
申请日:2005-10-20
申请人: Allen Hopper , Robert Dunn , Erik Kuester , Richard Conticello , Ruiping Liu , Ashok Tehim
发明人: Allen Hopper , Robert Dunn , Erik Kuester , Richard Conticello , Ruiping Liu , Ashok Tehim
IPC分类号: A61K31/497 , A61K31/433 , A61K31/4245
CPC分类号: C07D207/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译: 选择性PDE4的抑制是通过新的化合物,例如4-(取代的 - 苯基)-2-吡咯烷酮化合物实现的。 本发明的化合物具有式I:其中R 1,R 2和R 3如本文所定义。 本公开还涉及制备这种化合物的方法,含有这些化合物的组合物及其使用方法。
-
公开(公告)号:US20070287707A1
公开(公告)日:2007-12-13
申请号:US11712264
申请日:2007-02-27
IPC分类号: A61K31/498 , A61K31/5377 , A61P25/18 , C07D237/28 , C07D413/02
CPC分类号: C07D237/28 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/04 , C07D413/04 , C07D413/10 , C07D417/04 , C07D471/04
摘要: The present invention if directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compounds containing the same and processes for preparing the same. The invention is also directed to methods of treating diseases mediated by PDE10 enzyme such as obesity, non-insulin dependent diabetes, schizophrenia or bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译: 本发明如果针对某些作为PDE10抑制剂的噌啉化合物,含有它们的药物化合物及其制备方法。 本发明还涉及治疗由PDE10酶介导的疾病如肥胖症,非胰岛素依赖性糖尿病,精神分裂症或双相情感障碍,强迫症等的疾病的方法。
-
公开(公告)号:US20070265270A1
公开(公告)日:2007-11-15
申请号:US11708868
申请日:2007-02-20
申请人: Stephen Hitchcock , Ruiping Liu , Mark Arrington , Allen Hopper , Richard Conticello , Truc Nguyen , M. Danca , Carla Gauss
发明人: Stephen Hitchcock , Ruiping Liu , Mark Arrington , Allen Hopper , Richard Conticello , Truc Nguyen , M. Danca , Carla Gauss
IPC分类号: A61K31/502 , A61K31/5375 , A61P25/00 , A61P25/18 , A61P3/00 , C07D237/28 , C07D295/00
CPC分类号: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14
摘要: The present invention is directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. The invention is also directed to methods of treating diseases treatable by modulation of PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译: 本发明涉及某些作为PDE10抑制剂的噌啉化合物,含有这些化合物的药物组合物及其制备方法。 本发明还涉及治疗通过调节PDE10酶可治疗的疾病的方法,例如肥胖症,非胰岛素依赖型糖尿病,精神分裂症,双相情感障碍,强迫症等。
-
-
-
-
-
-
-
-
-