公开(公告)号：US09296685B2

公开(公告)日：2016-03-29

申请号：US13583536

申请日：2011-03-07

申请人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

发明人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

IPC分类号： C07C69/36 ,  C07C271/08 ,  B01F17/00 ,  C07C69/38 ,  C07C233/56

CPC分类号： C07C271/08 ,  B01F17/0007 ,  B01F17/0021 ,  C07C69/36 ,  C07C69/38 ,  C07C233/56

摘要： Method of producing a nanoparticle suspension with the steps (i) preparation of an emulsion of a disperse polar phase, where the aqueous phase comprises one or more precursor substances forming the nanoparticles, in a continuous organic phase in the presence of an emulsifier stabilizing the emulsion, (ii) conversion of the one or more precursor substances to nanoparticles in the disperse aqueous phase, (iii) breaking of the emulsion and phase separation, where the nanoparticle suspension is obtained as one phase, (iv) separation off of the nanoparticle suspension, (v) optionally isolation of the nanoparticles from the nanoparticle suspension, wherein the emulsifier is selected from compounds of the general formula (I) in which X is O, NH, Y is C(O), NH, R is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 6 to 30 carbon atoms and R1 is hydrogen or C1-C4-alkyl, and R2 is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 1 to 30 carbon atoms, preferably 6 to 30 carbon atoms, R3 is C1-C4-alkyl, n is 0 or 1, and the breaking of the emulsion is effected by splitting the emulsifier.

摘要翻译： 制备纳米颗粒悬浮液的方法，步骤（i）制备分散极性相的乳液，其中水相包含一种或多种形成纳米颗粒的前体物质，在连续的有机相中，在稳定乳液的乳化剂存在下 ，（ii）将一种或多种前体物质转化为分散水相中的纳米颗粒，（iii）破乳和相分离，其中纳米颗粒悬浮液作为一相获得，（iv）将纳米颗粒悬浮液分离 ，（v）任选地从纳米颗粒悬浮液中分离纳米颗粒，其中所述乳化剂选自X为O，NH，Y为C（O），NH，R为饱和的或通式 具有6至30个碳原子的单或多不饱和的直链或支链烃基，R 1是氢或C 1 -C 4 - 烷基，R 2是饱和或单不饱和或多不饱和的直链或支链烃 具有1至30个碳原子，优选6至30个碳原子的二烷基，R 3是C 1 -C 4 - 烷基，n是0或1，并且通过分裂乳化剂来实现乳液的断裂。

公开(公告)号：US20120329888A1

公开(公告)日：2012-12-27

申请号：US13583536

申请日：2011-03-07

申请人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

发明人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

IPC分类号： B01J13/00 ,  C07C69/36 ,  C07C69/38 ,  C07C233/56 ,  C07C271/12

CPC分类号： C07C271/08 ,  B01F17/0007 ,  B01F17/0021 ,  C07C69/36 ,  C07C69/38 ,  C07C233/56

摘要： Method of producing a nanoparticle suspension with the steps (i) preparation of an emulsion of a disperse polar phase, where the aqueous phase comprises one or more precursor substances forming the nanoparticles, in a continuous organic phase in the presence of an emulsifier stabilizing the emulsion, (ii) conversion of the one or more precursor substances to nanoparticles in the disperse aqueous phase, (iii) breaking of the emulsion and phase separation, where the nanoparticle suspension is obtained as one phase, (iv) separation off of the nanoparticle suspension, (v) optionally isolation of the nanoparticles from the nanoparticle suspension, wherein the emulsifier is selected from compounds of the general formula (I) in which X is O, NH, Y is C(O), NH, R is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 6 to 30 carbon atoms and R1 is hydrogen or C1-C4-alkyl, and R2 is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 1 to 30 carbon atoms, preferably 6 to 30 carbon atoms, R3 is C1-C4-alkyl, n is 0 or 1, and the breaking of the emulsion is effected by splitting the emulsifier.

摘要翻译： 制备纳米颗粒悬浮液的方法，步骤（i）制备分散极性相的乳液，其中水相包含一种或多种形成纳米颗粒的前体物质，在连续的有机相中，在稳定乳液的乳化剂存在下 ，（ii）将一种或多种前体物质转化为分散水相中的纳米颗粒，（iii）破乳和相分离，其中纳米颗粒悬浮液作为一相获得，（iv）将纳米颗粒悬浮液分离 ，（v）任选地从纳米颗粒悬浮液中分离纳米颗粒，其中所述乳化剂选自X为O，NH，Y为C（O），NH，R为饱和的或通式 具有6至30个碳原子的单或多不饱和的直链或支链烃基，R 1是氢或C 1 -C 4 - 烷基，R 2是饱和或单不饱和或多不饱和的直链或支链烃 具有1至30个碳原子，优选6至30个碳原子的二烷基，R 3是C 1 -C 4 - 烷基，n是0或1，并且通过分裂乳化剂来实现乳液的断裂。