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    Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
    1.
    发明授权
    Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders 有权
    止血导管和治疗中风和其他小血管血栓栓塞障碍的方法

    公开(公告)号：US06685722B1

    公开(公告)日：2004-02-03

    申请号：US09437530

    申请日：1999-11-10

    申请人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti

    发明人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti

    IPC分类号： A61M2900

    CPC分类号： A61B17/22032 ,  A61B17/135 ,  A61B17/221 ,  A61B2017/22034 ,  A61B2017/22044 ,  A61B2017/22077 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/320716 ,  A61F2/013 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/008 ,  A61F2230/0091 ,  A61M2025/0042 ,  A61M2025/0183

    摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.

    摘要翻译： 用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。 本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。 在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。 此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。 凝块移除装置可以包括被设计成防止血块从其中通过的可展开的线巢。 输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。 外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。 输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。

    Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
    2.
    发明授权
    Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders 有权
    止血导管和治疗中风和其他小血管血栓栓塞障碍的方法

    公开(公告)号：US08100935B2

    公开(公告)日：2012-01-24

    申请号：US11773601

    申请日：2007-07-05

    申请人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti

    发明人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti

    IPC分类号： A61M29/00

    CPC分类号： A61B17/22032 ,  A61B17/135 ,  A61B17/221 ,  A61B2017/22034 ,  A61B2017/22044 ,  A61B2017/22077 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/320716 ,  A61F2/013 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/008 ,  A61F2230/0091 ,  A61M2025/0042 ,  A61M2025/0183

    摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.

    摘要翻译： 用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。 本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。 在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。 此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。 凝块移除装置可以包括被设计成防止血块从其中通过的可展开的线巢。 输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。 外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。 输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。

    Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
    4.
    发明授权
    Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders 有权
    止血导管和治疗中风和其他小血管血栓栓塞障碍的方法

    公开(公告)号：US07691121B2

    公开(公告)日：2010-04-06

    申请号：US10730860

    申请日：2003-12-09

    申请人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti

    发明人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti

    IPC分类号： A61M29/00

    CPC分类号： A61B17/22032 ,  A61B17/135 ,  A61B17/221 ,  A61B2017/22034 ,  A61B2017/22044 ,  A61B2017/22077 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/320716 ,  A61F2/013 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/008 ,  A61F2230/0091 ,  A61M2025/0042 ,  A61M2025/0183

    摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may included a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.

    摘要翻译： 用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。 本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。 在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。 此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。 凝块移除装置可以包括设计成防止血块从其中通过的可展开的线窝。 输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。 外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。 输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。

    Flow directed catheter
    8.
    发明授权
    Flow directed catheter 有权
    导流导管

    公开(公告)号：US06296631B2

    公开(公告)日：2001-10-02

    申请号：US09734201

    申请日：2000-12-12

    申请人： Sean L. Chow

    发明人： Sean L. Chow

    IPC分类号： A61M2500

    CPC分类号： A61M25/0125 ,  A61M25/0012 ,  A61M25/0045 ,  A61M25/0053 ,  A61M25/0054 ,  A61M2025/0042

    摘要： A flow directed microcatheter is formed having a gradually changing flexibility and diameter between a proximal end and a distal end of the microcatheter. The changing properties of the microcatheter according to the present invention provide the flexibility of the distal tip needed to allow the microcatheter to be directed by the flow of blood within the vasculature, and the columnar strength and torquability at the proximal end and along the length of the microcatheter needed to advance and direct the distal tip to the target site. A proximal segment of the microcatheter includes a plurality of strands which vary in diameter to change the flexibility of the microcatheter. A distal segment of the microcatheter includes an inner layer which is compatible with solvents, such as DMSO, and an outer layer which provides strength and flexibility. The proximal segment and the distal segment of the microcatheter are joined by a kink resistant fuse joint.

    摘要翻译： 形成流导微型导管，其在微导管的近端和远端之间具有逐渐变化的柔性和直径。 根据本发明的微型导管的变化特性提供了需要的远端尖端的灵活性，以允许微导管由脉管系统内的血液流引导，并且在近端和长度方向上的柱状强度和扭力 微导管需要推进并将远端引导到目标部位。 微导管的近端段包括多个直径变化的股线，以改变微导管的柔性。 微导管的远端部分包括与诸如DMSO的溶剂相容的内层和提供强度和柔性的外层。 微导管的近端段和远端段通过耐扭结熔断体连接。

    Flow directed catheter
    9.
    发明授权
    Flow directed catheter 失效

    公开(公告)号：US06171296B2

    公开(公告)日：2001-01-09

    申请号：US09066861

    申请日：1998-04-28

    申请人： Sean L. Chow

    发明人： Sean L. Chow

    IPC分类号： A61M2500

    CPC分类号： A61M25/0125 ,  A61M25/0012 ,  A61M25/0045 ,  A61M25/0053 ,  A61M25/0054 ,  A61M2025/0042

    摘要： A flow directed microcatheter is formed having a gradually changing flexibility and diameter between a proximal end and a distal end of the microcatheter. The changing properties of the microcatheter according to the present invention provide the flexibility of the distal tip needed to allow the microcatheter to be directed by the flow of blood within the vasculature, and the columnar strength and torquability at the proximal end and along the length of the microcatheter needed to advance and direct the distal tip to the target site. A proximal segment of the microcatheter includes a plurality of strands which vary in diameter to change the flexibility of the microcatheter. A distal segment of the microcatheter includes an inner layer which is compatible with solvents, such as DMSO, and an outer layer which provides strength and flexibility. The proximal segment and the distal segment of the microcatheter are joined by a kink resistant fuse joint.