公开(公告)号：US20090197324A1

公开(公告)日：2009-08-06

申请号：US12099725

申请日：2008-04-08

申请人： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

发明人： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

IPC分类号： A01N1/02

CPC分类号： A01N1/021 ,  A01N1/02 ,  A01N1/0247

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US20090197325A1

公开(公告)日：2009-08-06

申请号：US12099728

申请日：2008-04-08

申请人： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

发明人： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

IPC分类号： A01N1/02

CPC分类号： A01N1/021 ,  A01N1/02 ,  A01N1/0247

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

摘要翻译： 维持，评估和提供肺外治疗的方法和系统。 所述方法和系统包括将肺定位在离体灌注电路中; 循环灌注液通过肺，流体通过肺动脉界面进入肺，并使肺通过左心房界面; 并使通气气体通过气管界面通气。 长时间维持肺包括使肺脏重新吸收一定体积的空气，并达到灌注流体和通气气体之间的平衡状态。 评估肺的气体交换能力包括对灌注液进行脱氧，并测量通过用氧合气通气肺来再灌注灌注液所需的时间。