公开(公告)号：US10750738B2

公开(公告)日：2020-08-25

申请号：US12099687

申请日：2008-04-08

申请人： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Thomas H. Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

发明人： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Thomas H. Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC分类号： C12Q1/02 ,  C12M1/00 ,  A01N1/02

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US09462802B2

公开(公告)日：2016-10-11

申请号：US12099725

申请日：2008-04-08

申请人： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

发明人： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC分类号： A01N1/02

CPC分类号： A01N1/021 ,  A01N1/02 ,  A01N1/0247

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US09247728B2

公开(公告)日：2016-02-02

申请号：US12099715

申请日：2008-04-08

申请人： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

发明人： Robert Fishman ,  Robert Havener ,  Ihab Abdel Fattah ,  Anas Abdelazim ,  Scott Newell ,  Tom Bishop ,  Tamer Khayal ,  Stanley Kyi ,  Ron Taylor ,  Doug Harriott ,  Matthew De Remer ,  Paul Murray ,  John Sullivan ,  Mark Anderson ,  Richard Bringham ,  Michael Van Driel ,  Waleed Hassanein

IPC分类号： A61M16/00 ,  A01N1/02

CPC分类号： A01N1/021 ,  A01N1/02 ,  A01N1/0247

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US07654084B2

公开(公告)日：2010-02-02

申请号：US11534979

申请日：2006-09-25

申请人： Eric Jensen ,  Christopher C. Langenfeld ,  Scott Newell ,  Michael Norris ,  Jeffrey D. Renk ,  Andrew Schnellinger

发明人： Eric Jensen ,  Christopher C. Langenfeld ,  Scott Newell ,  Michael Norris ,  Jeffrey D. Renk ,  Andrew Schnellinger

IPC分类号： F01B29/10

CPC分类号： F23N1/002 ,  F02B77/085 ,  F02D19/023 ,  F02D19/027 ,  F02G1/043 ,  F02G1/047 ,  F02G1/055 ,  F02G2244/00 ,  F02G2254/10 ,  F02G2255/00 ,  F02M21/0212 ,  F02M21/0245 ,  F23D14/60 ,  F23K5/007 ,  F23K2401/201 ,  F23K2900/05003 ,  F23N1/022 ,  F23N3/082 ,  F23N5/006 ,  F23N2021/08 ,  F23N2025/14 ,  F23N2027/02 ,  F23N2027/04 ,  F23N2033/08 ,  G05D7/0676 ,  Y02T10/32

摘要： A device and method for controlling the flow of a gaseous fuel from a fuel supply to a pressurized combustion chamber. A fuel pump is included in the gas train from supply to chamber. The fuel pump increases the pressure of the gas to allow efficient injection into the chamber. The pump is modulated to control the fuel flow. Both alternating current and pulse-width-modulated direct current signals may be used to control the flow. The pump may be a piston pump or a diaphragm pump. Feedback may be provided from sensors that determine operating parameters of the engine and such sensor signals may be used by the controller to maintain a parameter, such as temperature, at a specified value. An acoustic filter can be included in the gas train to significantly reduce gas flow pulsations generated by the pump. This filter improves the uniformity of the combustion process.

摘要翻译： 一种用于控制气体燃料从燃料供应到加压燃烧室的流动的装置和方法。 从供气到室的燃气列车中包括一个燃油泵。 燃料泵增加了气体的压力，以便有效地注入到腔室中。 泵被调制以控制燃料流量。 可以使用交流电流和脉冲宽度调制的直流信号来控制流量。 泵可以是活塞泵或隔膜泵。 可以由确定发动机的运行参数的传感器提供反馈，并且控制器可以使用这样的传感器信号来将诸如温度的参数保持在指定值。 声学过滤器可以包括在气体系列中，以显着减少由泵产生的气流脉动。 该过滤器改善了燃烧过程的均匀性。

公开(公告)号：US20090197325A1

公开(公告)日：2009-08-06

申请号：US12099728

申请日：2008-04-08

申请人： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

发明人： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

IPC分类号： A01N1/02

CPC分类号： A01N1/021 ,  A01N1/02 ,  A01N1/0247

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

摘要翻译： 维持，评估和提供肺外治疗的方法和系统。 所述方法和系统包括将肺定位在离体灌注电路中; 循环灌注液通过肺，流体通过肺动脉界面进入肺，并使肺通过左心房界面; 并使通气气体通过气管界面通气。 长时间维持肺包括使肺脏重新吸收一定体积的空气，并达到灌注流体和通气气体之间的平衡状态。 评估肺的气体交换能力包括对灌注液进行脱氧，并测量通过用氧合气通气肺来再灌注灌注液所需的时间。

公开(公告)号：US07111460B2

公开(公告)日：2006-09-26

申请号：US10643147

申请日：2003-08-18

申请人： Eric Jensen ,  Christopher C. Langenfeld ,  Scott Newell ,  Michael Norris ,  Jeffrey D. Renk ,  Andrew Schnellinger

发明人： Eric Jensen ,  Christopher C. Langenfeld ,  Scott Newell ,  Michael Norris ,  Jeffrey D. Renk ,  Andrew Schnellinger

IPC分类号： F01B29/10

CPC分类号： F23N1/002 ,  F02B77/085 ,  F02D19/023 ,  F02D19/027 ,  F02G1/043 ,  F02G1/047 ,  F02G1/055 ,  F02G2244/00 ,  F02G2254/10 ,  F02G2255/00 ,  F02M21/0212 ,  F02M21/0245 ,  F23D14/60 ,  F23K5/007 ,  F23K2401/201 ,  F23K2900/05003 ,  F23N1/022 ,  F23N3/082 ,  F23N5/006 ,  F23N2021/08 ,  F23N2025/14 ,  F23N2027/02 ,  F23N2027/04 ,  F23N2033/08 ,  G05D7/0676 ,  Y02T10/32

摘要： A device and method for controlling the flow of a gaseous fuel from a fuel supply to a pressurized combustion chamber. A fuel pump is included in the gas train from supply to chamber. The fuel pump increases the pressure of the gas to allow efficient injection into the chamber. The pump is modulated to control the fuel flow. Both alternating current and pulse-width-modulated direct current signals may be used to control the flow. The pump may be a piston pump or a diaphragm pump. Feedback may be provided from sensors that determine operating parameters of the engine and such sensor signals may be used by the controller to maintain a parameter, such as temperature, at a specified value. An acoustic filter can be included in the gas train to significantly reduce gas flow pulsations generated by the pump. This filter improves the uniformity of the combustion process.

摘要翻译： 一种用于控制气体燃料从燃料供应到加压燃烧室的流动的装置和方法。 从供气到室的燃气列车中包括一个燃油泵。 燃料泵增加了气体的压力，以便有效地注入到腔室中。 泵被调制以控制燃料流量。 可以使用交流电流和脉冲宽度调制的直流信号来控制流量。 泵可以是活塞泵或隔膜泵。 可以由确定发动机的运行参数的传感器提供反馈，并且控制器可以使用这样的传感器信号来将诸如温度的参数保持在指定值。 声学过滤器可以包括在气体系列中，以显着减少由泵产生的气流脉动。 该过滤器改善了燃烧过程的均匀性。

公开(公告)号：US20050188674A1

公开(公告)日：2005-09-01

申请号：US11054352

申请日：2005-02-09

申请人： Christopher Langenfeld ,  Scott Newell ,  Thomas Schnellinger

发明人： Christopher Langenfeld ,  Scott Newell ,  Thomas Schnellinger

IPC分类号： F02G1/00 ,  F02G1/045 ,  F02G3/00

CPC分类号： F02G1/045 ,  F02G2270/90

摘要： An electromechanical compression release valve for compressors, engines with rotary or reciprocating mechanisms and external combustion engines, such as, a Stirling cycle engine, reduces the engine starting power by reducing the compression pressure in the cylinder head space area. The valve reduces the compression pressure by passing the working fluid from the cylinder head space to another compartment. The valve comprises a housing, a valve member, a valve-driving member, a valve position sensor, and a ratchet pawl. In the open position, and while starting the engine, the inlet of the rotatable valve member is aligned with the opening in a chamber connected to the engine work space, thus, the working fluid passes through the valve member into the crankcase. After the engine starts, the valve position sensor directs the valve-driving member to rotate the valve member to the closed position. When closed, the engine working fluid can now achieve the operating compression pressures.

摘要翻译： 用于压缩机的机电压缩释放阀，具有旋转或往复运动机构的发动机和诸如斯特林循环发动机的外部燃烧发动机通过降低气缸盖空间区域中的压缩压力来降低发动机起动功率。 阀通过将工作流体从气缸盖空间传递到另一隔室来减小压缩压力。 阀包括壳体，阀构件，阀驱动构件，阀位传感器和棘爪。 在打开位置，在启动发动机的同时，可旋转阀构件的入口与连接到发动机工作空间的室中的开口对准，从而工作流体通过阀构件进入曲轴箱。 在发动机起动之后，阀位传感器引导阀驱动构件将阀构件旋转到关闭位置。 当关闭时，发动机工作液现在可以实现操作压缩压力。

公开(公告)号：US08465970B2

公开(公告)日：2013-06-18

申请号：US11246902

申请日：2005-10-07

申请人： Waleed Hassanein ,  Richard Bringham ,  Giovanni Cecere ,  Ahmed Elbetanony ,  Robert Fishman ,  Larry Goff ,  Tamer Khayal ,  Stanley Kyi ,  Scott Newell ,  Burt Ochs ,  Dennis Sousa ,  Ronald Taylor ,  Jonathan Rourke ,  Hossam Algamil ,  David Carpenter ,  Robert Havner ,  Dmitri Menn

发明人： Waleed Hassanein ,  Richard Bringham ,  Giovanni Cecere ,  Ahmed Elbetanony ,  Robert Fishman ,  Larry Goff ,  Tamer Khayal ,  Stanley Kyi ,  Scott Newell ,  Burt Ochs ,  Dennis Sousa ,  Ronald Taylor ,  Jonathan Rourke ,  Hossam Algamil ,  David Carpenter ,  Robert Havner ,  Dmitri Menn

IPC分类号： C12M1/12

CPC分类号： A01N1/0242 ,  A01N1/02 ,  A01N1/0226 ,  A01N1/0247

摘要： The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.

公开(公告)号：US20090197324A1

公开(公告)日：2009-08-06

申请号：US12099725

申请日：2008-04-08

申请人： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

发明人： Robert FISHMAN ,  Robert HAVENER ,  Ihab Abdel FATTAH ,  Anas ABDELAZIM ,  Scott NEWELL ,  Tom BISHOP ,  Tamer KHAYAL ,  Stanley KYI ,  Ron TAYLOR ,  Doug HARRIOTT ,  Matthew DE REMER ,  Paul MURRAY ,  John SULLIVAN ,  Mark ANDERSON ,  Richard BRINGHAM ,  Michael VAN DRIEL ,  Waleed Hassanein

IPC分类号： A01N1/02

CPC分类号： A01N1/021 ,  A01N1/02 ,  A01N1/0247

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：US20070028612A1

公开(公告)日：2007-02-08

申请号：US11534979

申请日：2006-09-25

申请人： Eric Jensen ,  Christopher Langenfeld ,  Scott Newell ,  Michael Norris ,  Jeffrey Renk ,  Andrew Schnellinger

发明人： Eric Jensen ,  Christopher Langenfeld ,  Scott Newell ,  Michael Norris ,  Jeffrey Renk ,  Andrew Schnellinger

IPC分类号： F02G1/04

CPC分类号： F23N1/002 ,  F02B77/085 ,  F02D19/023 ,  F02D19/027 ,  F02G1/043 ,  F02G1/047 ,  F02G1/055 ,  F02G2244/00 ,  F02G2254/10 ,  F02G2255/00 ,  F02M21/0212 ,  F02M21/0245 ,  F23D14/60 ,  F23K5/007 ,  F23K2401/201 ,  F23K2900/05003 ,  F23N1/022 ,  F23N3/082 ,  F23N5/006 ,  F23N2021/08 ,  F23N2025/14 ,  F23N2027/02 ,  F23N2027/04 ,  F23N2033/08 ,  G05D7/0676 ,  Y02T10/32

摘要： A device and method for controlling the flow of a gaseous fuel from a fuel supply to a pressurized combustion chamber. A fuel pump is included in the gas train from supply to chamber. The fuel pump increases the pressure of the gas to allow efficient injection into the chamber. The pump is modulated to control the fuel flow. Both alternating current and pulse-width-modulated direct current signals may be used to control the flow. The pump may be a piston pump or a diaphragm pump. Feedback may be provided from sensors that determine operating parameters of the engine and such sensor signals may be used by the controller to maintain a parameter, such as temperature, at a specified value. An acoustic filter can be included in the gas train to significantly reduce gas flow pulsations generated by the pump. This filter improves the uniformity of the combustion process.

摘要翻译： 一种用于控制气体燃料从燃料供应到加压燃烧室的流动的装置和方法。 从供气到室的燃气列车中包括一个燃油泵。 燃料泵增加了气体的压力，以便有效地注入到腔室中。 泵被调制以控制燃料流量。 可以使用交流电流和脉冲宽度调制的直流信号来控制流量。 泵可以是活塞泵或隔膜泵。 可以由确定发动机的运行参数的传感器提供反馈，并且控制器可以使用这样的传感器信号来将诸如温度的参数保持在指定值。 声学过滤器可以包括在气体系列中，以显着减少由泵产生的气流脉动。 该过滤器改善了燃烧过程的均匀性。