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188 条记录 (耗时 0.041 秒)

    MULTI-EDGE OSCILLATING SAW BLADE
    1.
    发明申请
    MULTI-EDGE OSCILLATING SAW BLADE 有权

    公开(公告)号：US20230139730A1

    公开(公告)日：2023-05-04

    申请号：US18090751

    申请日：2022-12-29

    申请人： William Zachary Ward ,  Mark Anderson Wilson

    发明人： William Zachary Ward ,  Mark Anderson Wilson

    IPC分类号： B23D61/00

    摘要： The present disclosure provides a multi-edge saw blade for use with an oscillating tool that provides multiple cutting edges that can be used sequentially as each cutting edge becomes worn-out or damaged. The multi-edge saw blade includes a first row of cutting teeth arranged across its distal edge and a row of perforations situated across the distal end of the blade and spaced a distance behind the first row of cutting teeth. In some aspects, the multi-edge saw blade further includes at least one additional row of perforations, each situated a spaced distance behind the row of perforations before it. Responsive to a twisting force applied orthogonally to the plane of the blade, each blade edge can be removed from the blade to reveal a fresh row of cutting teeth. The multi-edge saw blade further includes an attachment socket on its proximate end.

    Fifth Wheel Lubricant Applicator Tool, Kit, and Method of Use
    2.
    发明申请
    Fifth Wheel Lubricant Applicator Tool, Kit, and Method of Use 有权

    公开(公告)号：US20220324524A1

    公开(公告)日：2022-10-13

    申请号：US17712637

    申请日：2022-04-04

    申请人： Mark ANDERSON

    发明人： Mark ANDERSON ,  Eric Paul ROSE

    IPC分类号： B62D53/08

    摘要： A fifth wheel lubricant applicator tool, kit, and method of use are disclosed. The lubricant applicator tool comprises a handle portion and an operative portion. The handle portion has a first width and a defined length. The operative portion extends out from the defined length of the handle portion such that a second width of the operative portion remains less than a length of the lubricant applicator tool. The operative portion comprises a working edge equipped with a plurality of indentations that are identical and evenly spaced. The width and the height of each of the plurality of indentations permits an application of a lubricant in parallel beads, each spaced apart from adjacent beads by a defined distance that is substantially same as a distance between two adjacent indentations.

    Use of calmodulin kinase II inhibitors to treat myocardial dysfunction in structural heart disease
    7.
    发明申请
    Use of calmodulin kinase II inhibitors to treat myocardial dysfunction in structural heart disease 失效
    使用钙调蛋白激酶II抑制剂治疗结构性心脏病的心肌功能障碍

    公开(公告)号：US20090011989A1

    公开(公告)日：2009-01-08

    申请号：US11983987

    申请日：2007-11-13

    申请人： Mark Anderson

    发明人： Mark Anderson

    IPC分类号： A61K38/16 ,  A61P9/00

    CPC分类号： A61K38/16 ,  A61K31/18 ,  A61K38/005 ,  A61K38/10 ,  C12Q1/485 ,  G01N33/5088 ,  G01N33/6893 ,  G01N2333/58 ,  G01N2333/912 ,  G01N2500/00 ,  G01N2500/10

    摘要： The present invention provides a method for treating structural heart disease in a subject, comprising administering an effective amount of an inhibitor of CaMKII to the subject, whereby the administration of the inhibitor treats the structural heart disease in the subject. Also provided are transgenic animal models for treating structural heart disease. Further provided is a means of screening for a compound that can treat structural heart disease.

    摘要翻译： 本发明提供一种用于治疗受试者的结构性心脏病的方法，包括向所述受试者施用有效量的CaMKII抑制剂，由此所述抑制剂的给药治疗受试者的结构性心脏病。 还提供用于治疗结构性心脏病的转基因动物模型。 进一步提供了筛选可治疗结构性心脏病的化合物的方法。

    Therapeutic Uses For Aminosterol Compounds
    8.
    发明申请
    Therapeutic Uses For Aminosterol Compounds 审中-公开
    氨基甾醇化合物的治疗用途

    公开(公告)号：US20080221075A1

    公开(公告)日：2008-09-11

    申请号：US12041440

    申请日：2008-03-03

    申请人： Michael Zasloff ,  Jon Williams ,  William Kinney ,  Mark Anderson ,  Michael McLane

    发明人： Michael Zasloff ,  Jon Williams ,  William Kinney ,  Mark Anderson ,  Michael McLane

    IPC分类号： A61K31/56 ,  C07J41/00 ,  A61P3/04

    CPC分类号： A61K31/575 ,  C07J41/0055

    摘要： A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.

    摘要翻译： 药物组合物包含作为活性成分的如图14所示的根据式1436的化合物。 1，或其药学上可接受的盐，和药学上可接受的载体或赋形剂。 可以生产包括该药物组合物的各种药物。 这样的药物可以用于治疗肥胖或糖尿病。 还描述了使用药物组合物的方法。 在这些方法中，通过施用有效量的药物组合物来治疗各种疾病或其他身体功能被激活或抑制。 例如，可以通过施用有效量的药物组合物来治疗糖尿病和肥胖症。 通过施用有效量的这些药物组合物可以抑制体重增加和生长因子产生。 可以通过施用有效量的药物组合物来抑制食欲，并且可以产生利尿作用。

    Multi-layer interconnect with isolation layer
    9.
    发明授权
    Multi-layer interconnect with isolation layer 有权
    具有隔离层的多层互连

    公开(公告)号：US07375033B2

    公开(公告)日：2008-05-20

    申请号：US10713845

    申请日：2003-11-14

    申请人： Todd Albertson ,  Darin Miller ,  Mark Anderson

    发明人： Todd Albertson ,  Darin Miller ,  Mark Anderson

    IPC分类号： H01L21/302

    CPC分类号： H01L21/76834 ,  H01L21/76801

    摘要： An integrated circuit interconnect is fabricated by using a mask to form a via in an insulating layer for a conductive plug. After the plug is formed in the via, a thin (e.g.,

    摘要翻译： 通过使用掩模在用于导电插塞的绝缘层中形成通孔来制造集成电路互连。 在插塞形成在通孔中之后，在所得到的结构上沉积薄（例如，<100nm）的隔离层。 通过在不同的辐射曝光水平下使用相同的掩模在隔离层中产生开口，以使开口比下面的塞子更窄。 然后形成导线，其通过隔离层中的开口与插头电接触。 通过将导电插塞与相邻的导电线垂直分离和电绝缘，隔离层有利地降低了在导电插塞和附近导电线之间出现不期望的电短路的可能性。