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    Cardiac disease treatment and device
    1.
    发明授权
    Cardiac disease treatment and device 有权
    心脏病治疗及器械

    公开(公告)号：US06902522B1

    公开(公告)日：2005-06-07

    申请号：US09591754

    申请日：2000-06-12

    申请人： Robert G. Walsh ,  J. Edward Shapland, II ,  Donald G. Rohrbaugh ,  Donald F. Palme, II

    发明人： Robert G. Walsh ,  J. Edward Shapland, II ,  Donald G. Rohrbaugh ,  Donald F. Palme, II

    IPC分类号： A61M37/00 ,  A61F2/00 ,  A61F13/00 ,  A61N1/30 ,  A61N1/362 ,  A61N5/00

    CPC分类号： A61F2/2481

    摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A–V groove, the device including a jacket adapted to be secured to the heart, and a delivery source for the delivery of one or more therapeutic agents to the surface of the heart. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.

    摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由AV凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套，以及用于将一种或多种治疗剂递送至 心脏的表面。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。

    Cardiac disease treatment and device
    2.
    发明授权
    Cardiac disease treatment and device 失效
    心脏病治疗及器械

    公开(公告)号：US07326174B2

    公开(公告)日：2008-02-05

    申请号：US10839724

    申请日：2004-05-04

    申请人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

    发明人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

    IPC分类号： A61F13/00 ,  A61F2/00

    CPC分类号： A61F2/2481 ,  D04B21/12 ,  D10B2509/08 ,  Y10S977/907

    摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.

    摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。

    Cardiac disease treatment and device
    3.
    发明授权
    Cardiac disease treatment and device 有权
    心脏病治疗及器械

    公开(公告)号：US06730016B1

    公开(公告)日：2004-05-04

    申请号：US09591875

    申请日：2000-06-12

    申请人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

    发明人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

    IPC分类号： A61F200

    CPC分类号： A61F2/2481 ,  D04B21/12 ,  D10B2509/08 ,  Y10S977/907

    摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.

    摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并且假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。

    Cardiac disease treatment and device
    4.
    发明授权
    Cardiac disease treatment and device 有权
    心脏病治疗及器械

    公开(公告)号：US06482146B1

    公开(公告)日：2002-11-19

    申请号：US09593251

    申请日：2000-06-13

    申请人： Clifton A. Alferness ,  Donald G. Rohrbaugh ,  J. Edward Shapland ,  Michael J. Girard ,  Donald F. Palme, II ,  James E. Cox

    发明人： Clifton A. Alferness ,  Donald G. Rohrbaugh ,  J. Edward Shapland ,  Michael J. Girard ,  Donald F. Palme, II ,  James E. Cox

    IPC分类号： A61F200

    CPC分类号： A61F2/2481 ,  Y10S623/904

    摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.

    摘要翻译： 生物相容材料的护套具有尺寸设计用于心脏顶点的内部容积，以将其插入体积中并使护套滑过心脏。 护套具有在上下端之间的纵向尺寸，足以使护套围绕心脏的下部围绕心脏的瓣膜环并且进一步围绕下部以至少覆盖心脏的心室下端 。 护套适于固定在心脏上，护套至少围绕瓣膜环和心室下肢。 护套在心脏上是可调节的，以贴合地符合心脏的外部几何形状，并假设护套的最大调节体积以约束舒张期心脏超过最大调节体积的周向扩张，并允许心脏收缩期间不受阻碍的收缩 。