-
公开(公告)号：US20050266008A1
公开(公告)日：2005-12-01
申请号：US11093274
申请日：2005-03-28
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30
CPC分类号： C07K16/3061 , A61K2039/505 , C07K16/283 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-5 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-5, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
摘要翻译： 本发明提供以高亲和力特异性结合IRTA-5的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了用于检测IRTA-5的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。
-
2.发明申请公开(公告)号：US20070003561A1
公开(公告)日：2007-01-04
申请号：US10563976
申请日：2004-07-08
申请人： Anders Sorensen , Thomas Benfield , Jens Lundgren , Thomas Kempe
发明人： Anders Sorensen , Thomas Benfield , Jens Lundgren , Thomas Kempe
CPC分类号： C07K16/1275 , C07K16/283 , C07K2317/34
摘要： The present invention relates to a binding member comprising at least one binding domain capable of specifically binding Streptococcus pneumoniae surface adhesion A (PsaA) protein, in particular to a binding member having at least two binding domains, to the use of said binding members in diagnostic methods as well as for treatment. In a preferred embodiment the binding member is an antibody, such as a human antibody, or a fragment thereof, and it may also be a bispecific antibody.
摘要翻译： 本发明涉及包含至少一个能够特异性结合肺炎链球菌表面粘附素A（PsaA）蛋白质的结合结构域，特别是具有至少两个结合结构域的结合成员，使用所述结合成员在诊断中的用途 方法以及治疗。 在优选的实施方案中，结合成员是抗体，例如人抗体或其片段，并且它也可以是双特异性抗体。
-
搜索结果
2 条记录 (耗时 0.022 秒)
