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8 条记录 (耗时 0.02 秒)

    HUMAN ANTIBODIES THAT BIND CD19 AND USES THEREOF
    1.
    发明申请
    HUMAN ANTIBODIES THAT BIND CD19 AND USES THEREOF 审中-公开
    CD19的人体抗体及其用途

    公开(公告)号：US20100104509A1

    公开(公告)日：2010-04-29

    申请号：US12519149

    申请日：2007-12-13

    申请人： David John King ,  Chetana Rao-Naik ,  Chin Pan ,  Josephine Cardarelli ,  Diann Blanset

    发明人： David John King ,  Chetana Rao-Naik ,  Chin Pan ,  Josephine Cardarelli ,  Diann Blanset

    IPC分类号： A61K51/00 ,  C07K16/00 ,  A61K39/395

    CPC分类号： C07K16/2803 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

    摘要： Human monoclonal antibodies that specifically bind to CD19 with high affinity are disclosed The antibodies are capable of internalizing into CD19-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies are also provided Also provided are methods for detecting CD19, as well as methods for treating cancers, such as B cell malignancies, for example, non-Hodgkin's lymphoma, chronic lymphocytic leukemias, follicular lymphomas, diffuse large cell lymphomas of B lineage, and multiple myelomas using an anti-CD 19 anti-body

    摘要翻译： 公开了以高亲和力特异性结合CD19的人单克隆抗体。抗体能够内化成表达CD19的细胞或能够介导抗原依赖性细胞毒性编码抗体，表达载体，宿主细胞的核酸分子和表达 还提供了抗体还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含抗体的药物组合物。还提供了用于检测CD19的方法，以及用于治疗癌症的方法，例如B细胞恶性肿瘤，例如非霍奇金淋巴瘤 ，慢性淋巴细胞性白血病，滤泡性淋巴瘤，B系弥漫性大细胞淋巴瘤，以及使用抗CD19抗体的多种骨髓瘤

    Interferon alpha receptor 1 antibodies and their uses
    3.
    发明申请
    Interferon alpha receptor 1 antibodies and their uses 有权
    干扰素α受体1抗体及其用途

    公开(公告)号：US20060029601A1

    公开(公告)日：2006-02-09

    申请号：US11157494

    申请日：2005-06-20

    申请人： Josephine Cardarelli ,  Alison Witte ,  Mohan Srinivasan

    发明人： Josephine Cardarelli ,  Alison Witte ,  Mohan Srinivasan

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.

    摘要翻译： 本发明提供了与IFNAR-1结合并且能够抑制I型干扰素的生物活性的分离的人单克隆抗体。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制I型干扰素介导的病症的方法，包括使用本发明的抗体治疗自身免疫疾病，移植排斥或移植物抗宿主病的方法。

    Interferon alpha antibodies and their uses
    6.
    发明申请
    Interferon alpha antibodies and their uses 有权
    干扰素α抗体及其用途

    公开(公告)号：US20070014724A1

    公开(公告)日：2007-01-18

    申请号：US11009410

    申请日：2004-12-10

    申请人： Alison Witte ,  Denise Williams ,  Josephine Cardarelli ,  David King ,  David Passmore

    发明人： Alison Witte ,  Denise Williams ,  Josephine Cardarelli ,  David King ,  David Passmore

    IPC分类号： A61K51/00 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C12N5/06 ,  C07K16/24 ,  C07K16/46

    CPC分类号： C07K16/249 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76

    摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

    摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。

    Human anti-IRTA-5 antibodies
    7.
    发明申请
    Human anti-IRTA-5 antibodies 审中-公开
    人抗IRTA-5抗体

    公开(公告)号：US20050266008A1

    公开(公告)日：2005-12-01

    申请号：US11093274

    申请日：2005-03-28

    申请人： Robert Graziano ,  Josephine Cardarelli ,  Thomas Kempe ,  Beth Cutter ,  Mohan Srinivasan

    发明人： Robert Graziano ,  Josephine Cardarelli ,  Thomas Kempe ,  Beth Cutter ,  Mohan Srinivasan

    IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K16/30

    CPC分类号： C07K16/3061 ,  A61K2039/505 ,  C07K16/283 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/92

    摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-5 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-5, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.

    摘要翻译： 本发明提供以高亲和力特异性结合IRTA-5的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了用于检测IRTA-5的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。