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公开(公告)号：US09281171B2
公开(公告)日：2016-03-08
申请号：US11721260
申请日：2005-12-08
申请人： Robert Harold Bateman , Kevin Giles , Jeffery Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Jeffery Mark Brown , Steven Derek Pringle , Jason Lee Wildgoose
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyzer arranged upstream of an ion guide. Ions are scanned out of the mass selective ion trap or mass analyzer and are received in one or more axial potential wells created or formed within the ion guide. One or more transient DC voltages or potentials are preferably applied to the ion guide in order to create a plurality of axial potential wells which are translated along the length of the ion guide. Ions are released in packets from the exit of the ion guide and are orthogonally acceleration into a drift or flight region of an orthogonal acceleration Time of Flight mass analyzer with a relatively high duty cycle.
摘要翻译： 公开了一种质谱仪，其包括布置在离子导向器上游的质量选择性离子阱或质量分析器。 离子从质量选择性离子阱或质量分析器扫描出来，并被接收在一个或多个在离子导向器内产生或形成的轴向势阱中。 优选地将一个或多个瞬态DC电压或电位施加到离子导向器，以便产生沿离子导向件的长度平移的多个轴向势阱。 离子从离子导向器的出口释放出来的离子，并且正交加速到相对较高占空比的正交加速时间飞行质量分析器的漂移或飞行区域。
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公开(公告)号：US09673031B2
公开(公告)日：2017-06-06
申请号：US12302177
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
IPC分类号： H01J49/00
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed comprising a Time of Flight mass analyzer comprising an ion detector comprising an Analog to Digital Converter. Signals from the Analog to Digital Converter are digitized and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+i) which are stored in neighboring time bins T(n), T(n+1).
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公开(公告)号：US20100001180A1
公开(公告)日：2010-01-07
申请号：US12302168
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译： 公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。 来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。 如果从两个信号确定的到达时间落在相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。
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4.发明授权Time of flight mass spectrometer with analog to digital converter and method of using 有权具有模数转换器的飞行时间质谱仪及其使用方法公开(公告)号：US08809767B2
公开(公告)日：2014-08-19
申请号：US12302168
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译： 公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。 来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。 如果从两个信号确定的到达时间落在相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。
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公开(公告)号：US20090321628A1
公开(公告)日：2009-12-31
申请号：US12302177
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
IPC分类号： H01J49/26
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+i) which are stored in neighbouring time bins T(n), T(n+1).
摘要翻译： 公开了一种质谱仪，其包括飞行时间质量分析器，其包括离子检测器，该离子检测器包括模数转换器。 从模拟到数字转换器的信号被数字化，并确定离子的到达时间和强度。 每个离子到达事件的到达时间T0和强度S0被转换成存储在相邻时间段T（n），T（n + 1）中的两个分开的强度S（n），S（n + i）。
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公开(公告)号：US08952320B2
公开(公告)日：2015-02-10
申请号：US11719665
申请日：2005-11-18
CPC分类号： H01J49/4215 , H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).
摘要翻译： 公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。 具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。 有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。 缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。 离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器 装置（6）。
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公开(公告)号：US20090194688A1
公开(公告)日：2009-08-06
申请号：US11719665
申请日：2005-11-18
CPC分类号： H01J49/4215 , H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).
摘要翻译： 公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。 具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。 有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。 缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。 离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器 装置（6）。
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公开(公告)号：US20090173877A1
公开(公告)日：2009-07-09
申请号：US12092601
申请日：2005-11-10
CPC分类号： H01J49/004 , G01N27/622 , H01J49/0031 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a first ion trap or ion guide (2), a single ion mobility spectrometer or separator stage (3) and a second ion trap or ion guide (4) arranged downstream of the ion mobility spectrometer or separator (3). In a mode of operation ions from the second ion trap or ion guide (4) are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator (3).
摘要翻译： 公开了一种质谱仪，其包括第一离子阱或离子导向器（2），单离子迁移谱仪或分离器级（3）和设置在离子迁移谱仪或分离器（3）的下游的第二离子阱或离子导向器 ）。 在操作模式中，来自第二离子阱或离子导向器（4）的离子从第二离子阱或离子导向器返回到离子迁移谱仪或分离器（3）的上游。
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公开(公告)号：US09685313B2
公开(公告)日：2017-06-20
申请号：US12514972
申请日：2007-11-15
CPC分类号： H01J49/4215 , G01N27/622 , H01J49/004 , H01J49/426
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer and an ion gate. A collision cell is arranged downstream of the ion gate. The operation of the ion mobility spectrometer and the ion gate are synchronised so that only ions having a particular mass to charge ratio and a desired charge state are onwardly transmitted to the collision cell.
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公开(公告)号：US09607820B2
公开(公告)日：2017-03-28
申请号：US12306162
申请日：2007-06-25
CPC分类号： H01J49/429 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A mass spectrometer includes an ion mobility spectrometer or separator arranged upstream of a collision or fragmentation cell. Ions are separated according to their ion mobility within the ion mobility spectrometer or separator. The kinetic energy of the ions exiting the ion mobility spectrometer or separator is increased substantially linearly with time in order to optimize the fragmentation energy of ions as they enter the collision or fragmentation cell. During the time that the potential of the ion mobility spectrometer or separator is being varied, the potential of ion-optical components upstream of the ion mobility spectrometer or separator such as an ion source, ion guide, quadrupole mass filter, optional second collision or fragmentation cell and an ion trapping device are kept constant.
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