-
公开(公告)号：US20070031883A1
公开(公告)日：2007-02-08
申请号：US11545962
申请日：2006-10-10
申请人： Robert Kincaid , Jayati Ghosh , Bo Curry
发明人： Robert Kincaid , Jayati Ghosh , Bo Curry
摘要： Methods, systems and computer readable media for calling out genetic aberrations. Log ratio noise associated with log ratio signals read from respective probes on at least one array for signals representative of the same chromosomal locations in a test sample of nucleic acids and a reference sample of nucleic acids applied to the at least one array are estimated. Outliers for log ratio values from the reference sample to outliers for log ratio values from the test sample are compared. A copy number of one or more of the chromosomal locations in the test sample is outputted relative to the reference sample for viewing by a user.
摘要翻译： 用于呼出遗传畸变的方法，系统和计算机可读介质。 估计与在至少一个阵列上从相应探针读取的对数比率信号相关联的对数比噪声，所述信号表示核酸的测试样品和应用于至少一个阵列的核酸的参考样品中的相同染色体位置的信号。 比较从参考样本到测试样本对数比值的异常值的对数比值的异常值。 测试样品中的一个或多个染色体位置的拷贝数相对于参考样品被输出以供用户观看。
-
2.发明申请Method and system for analysis of array-based, comparative-hybridization data 有权基于阵列的比较杂交数据的分析方法和系统公开(公告)号：US20080120038A1
公开(公告)日：2008-05-22
申请号：US11492472
申请日：2006-07-24
申请人： Jayati Ghosh , Amir Ben-dor , Anya Tsalenko , Bo Curry
发明人： Jayati Ghosh , Amir Ben-dor , Anya Tsalenko , Bo Curry
IPC分类号： G06F19/00
摘要： Embodiments of the present invention include methods and systems for analysis of comparative genomic hybridization (“CGH”) data, including CGH data obtained from microarray experiments.
摘要翻译： 本发明的实施方案包括用于分析比较基因组杂交（“CGH”）数据的方法和系统，包括从微阵列实验获得的CGH数据。
-
3.发明申请Significance analysis using data smoothing with shaped response functions 审中-公开使用具有形状响应函数的数据平滑的意义分析公开(公告)号：US20070099227A1
公开(公告)日：2007-05-03
申请号：US11607786
申请日：2006-11-30
申请人： Bo Curry , Jayati Ghosh
发明人： Bo Curry , Jayati Ghosh
摘要： Methods, systems and computer readable media for analyzing data. A variable width window is applied to data points from the data which are ordered to correspond to locations along a chromosome of targeted nucleotide sequences whose relative abundances are represented by the data points. The window applied is a moving window, the width of which is variable upon movement of the window to capture a fixed number of the data points, wherein the width is symmetrical about the data point to which a weighted average is to be assigned. A response function is applied to the data points captured in the window. The response function is symmetrical about the data point to which a weighted average is to be assigned.
摘要翻译： 用于分析数据的方法，系统和计算机可读介质。 可变宽度窗口被应用于从数据排列的数据点，对应于沿着相对丰度由数据点表示的目标核苷酸序列的染色体的位置。 应用的窗口是移动窗口，其宽度在窗口移动时变化以捕获固定数量的数据点，其中宽度对于要分配加权平均数据点的对称关系。 响应函数应用于窗口中捕获的数据点。 响应函数对应于要分配加权平均数据的数据点。
-
公开(公告)号：US08332737B2
公开(公告)日：2012-12-11
申请号：US12492487
申请日：2009-06-26
申请人： Peter G. Webb , Jayati Ghosh , Bo Curry
发明人： Peter G. Webb , Jayati Ghosh , Bo Curry
CPC分类号： G06F11/3055 , G06F11/0736 , G06F11/0748 , G06F11/076 , G06F11/3013 , G06F11/3058
摘要： Methods, systems and computer readable media for controlling an instrument in communication with a host computer are provided. Operations of an instrument that must be completed on schedule are controlled via an embedded controller embedded in the instrument. A complete status packet is sent to a host computer from the embedded controller. Periodically, the embedded controller repeats the sending of a complete status packet to the host computer, wherein status values in the complete status packet are updated with each iteration of sending a complete status packet.
摘要翻译： 提供了用于控制与主计算机通信的仪器的方法，系统和计算机可读介质。 必须按计划完成的仪器的操作通过嵌入仪器中的嵌入式控制器进行控制。 完整的状态包从嵌入式控制器发送到主机。 周期性地，嵌入式控制器重复向主计算机发送完整的状态分组，其中通过每次发送完整状态分组的迭代来更新完整状态分组中的状态值。
-
公开(公告)号：US20100332953A1
公开(公告)日：2010-12-30
申请号：US12492487
申请日：2009-06-26
申请人： Peter G. Webb , Jayati Ghosh , Bo Curry
发明人： Peter G. Webb , Jayati Ghosh , Bo Curry
IPC分类号： H03M13/09
CPC分类号： G06F11/3055 , G06F11/0736 , G06F11/0748 , G06F11/076 , G06F11/3013 , G06F11/3058
摘要： Methods, systems and computer readable media for controlling an instrument in communication with a host computer are provided. Operations of an instrument that must be completed on schedule are controlled via an embedded controller embedded in the instrument. A complete status packet is sent to a host computer from the embedded controller Periodically, the embedded controller repeats the sending of a complete status packet to the host computer, wherein status values in the complete status packet are updated with each iteration of sending a complete status packet.
摘要翻译： 提供了用于控制与主计算机通信的仪器的方法，系统和计算机可读介质。 必须按计划完成的仪器的操作通过嵌入仪器中的嵌入式控制器进行控制。 完整的状态包从嵌入式控制器发送到主计算机周期性地，嵌入式控制器重复向主计算机发送完整的状态包，其中在完成状态包中的状态值被更新，每次迭代发送完整状态 包。
-
6.发明授权Method and system for analysis of array-based, comparative-hybridization data 有权基于阵列的比较杂交数据的分析方法和系统公开(公告)号：US07660675B2
公开(公告)日：2010-02-09
申请号：US11492472
申请日：2006-07-24
申请人： Jayati Ghosh , Amir Ben-dor , Anya Tsalenko , Bo Curry
发明人： Jayati Ghosh , Amir Ben-dor , Anya Tsalenko , Bo Curry
摘要： Embodiments of the present invention include methods and systems for analysis of comparative genomic hybridization (“CGH”) data, including CGH data obtained from microarray experiments.
摘要翻译： 本发明的实施方案包括用于分析比较基因组杂交（“CGH”）数据的方法和系统，包括从微阵列实验获得的CGH数据。
-
公开(公告)号：US20070082338A1
公开(公告)日：2007-04-12
申请号：US11193912
申请日：2005-07-29
申请人： Bo Curry , Jayati Ghosh
发明人： Bo Curry , Jayati Ghosh
CPC分类号： G06F19/20
摘要： Methods, systems and computer readable media for characterizing quality of CGH arrays, including generating at least one metric for a CGH array that characterizes a property of the CGH array; repeating generation of the at least one metric for at least one additional CGH array; and comparing each metric across all CGH array metric values generated to identify a quality of any one of the CGH arrays characterized, relative to the CGH arrays characterized for that metric. Methods, systems and computer readable media for determining the quality of a CGH array, including calculating a spread of the derivative of log ratio value differences between consecutive probes representing consecutive positions along a chromosome, wherein ratio values are calculated from probe signals from a CGH array, as read by a reader on first and second channels thereof, or from probes signals from two CGH arrays, as read by a single channel reader. Methods, systems and computer readable media for qualifying a CGH array, including quantifying an interarray reproducibility metric characterizing selected sets of probe replicates. Methods, systems and computer readable media for qualifying a CGH array, including generating a Receiver Operating Characteristic (ROC) curve and analyzing false positive and true positive signals from a normal male sample and a normal female sample, as read by a reader on first and second channels thereof, or from one of a normal male sample and a normal female sample on the CGH array and the other of the normal male sample and normal female sample on a second CGH array, as read by a single-channel reader. Methods, systems and computer readable media for determining the quality of a CGH array, including segmenting, by copy number, log ratio signals from probes on the CGH array representing a genome; plotting a probability distribution of the segmented log ratio values; and quantifying separation between copy number peaks resulting from the plotting of the probability distribution.
-
8.发明申请Methods and systems for detrending signal intensity data from chemical arrays 有权从化学阵列中去除信号强度数据的方法和系统公开(公告)号：US20090012732A1
公开(公告)日：2009-01-08
申请号：US12231517
申请日：2008-09-02
IPC分类号： G06F17/10
CPC分类号： G06F19/20
摘要： Methods, systems and computer readable media for removing trends in signal intensity values from features on a chemical array. Inputted signal values from features on the array are surface fitted to calculate a surface approximation. The surface approximation is normalized and used to de-trend the signal intensity values from the features.
摘要翻译： 用于从化学阵列上的特征消除信号强度值趋势的方法，系统和计算机可读介质。 来自阵列中特征的输入信号值进行表面拟合，以计算表面近似值。 表面近似被归一化并用于从特征中消除信号强度值。
-
公开(公告)号：US07437249B2
公开(公告)日：2008-10-14
申请号：US11479269
申请日：2006-06-30
CPC分类号： G06F19/20
摘要： Methods, systems and computer readable media for removing trends in signal intensity values from features on a chemical array. Inputted signal values from features on the array are surface fitted to calculate a surface approximation. The surface approximation is normalized and used to de-trend the signal intensity values from the features.
-
10.发明申请Methods and systems for detrending signal intensity data from chemical arrays 有权从化学阵列中去除信号强度数据的方法和系统公开(公告)号：US20080004824A1
公开(公告)日：2008-01-03
申请号：US11479269
申请日：2006-06-30
申请人： John Corson , Jayati Ghosh , Svetlana Shchegrova
发明人： John Corson , Jayati Ghosh , Svetlana Shchegrova
CPC分类号： G06F19/20
摘要： Methods, systems and computer readable media for removing trends in signal intensity values from features on a chemical array. Inputted signal values from features on the array are surface fitted to calculate a surface approximation. The surface approximation is normalized and used to de-trend the signal intensity values from the features.
摘要翻译： 用于从化学阵列上的特征消除信号强度值趋势的方法，系统和计算机可读介质。 来自阵列中特征的输入信号值进行表面拟合，以计算表面近似值。 表面近似被归一化并用于从特征中消除信号强度值。
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.02 秒)
