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33 条记录 (耗时 0.027 秒)

    Insertable nanoscale FET probe
    2.
    发明申请
    Insertable nanoscale FET probe 失效
    可插入纳米级FET探头

    公开(公告)号：US20070186628A1

    公开(公告)日：2007-08-16

    申请号：US11351515

    申请日：2006-02-10

    申请人： Bo Curry ,  Sungsoo Yi

    发明人： Bo Curry ,  Sungsoo Yi

    IPC分类号： G01B5/28

    CPC分类号： G01Q70/12 ,  G01Q60/30 ,  G01Q60/42

    摘要： The nanoscale FET probe comprises a cantilever element and, at one end of the cantilever element, a nanowire that extends from the cantilever element. The nanowire is electrically connected to the cantilever element at at least one of the ends of the nanowire. The nanowire is capable of being coated with molecules of a capture agent along at least part of its length.

    摘要翻译： 纳米级FET探针包括悬臂元件，并且在悬臂元件的一端具有从悬臂元件延伸的纳米线。 纳米线在纳米线的至少一个端部处电连接到悬臂元件。 纳米线能够沿着其长度的至少一部分被包裹有捕获剂的分子。

    Extended dynamic range reading of chemical arrays
    3.
    发明申请
    Extended dynamic range reading of chemical arrays 审中-公开
    扩大化学阵列的动态范围读数

    公开(公告)号：US20070178480A1

    公开(公告)日：2007-08-02

    申请号：US11344773

    申请日：2006-01-31

    申请人： John F. Corson ,  Bo Curry ,  Charles Troup ,  Xiangyang Zhou

    发明人： John F. Corson ,  Bo Curry ,  Charles Troup ,  Xiangyang Zhou

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： G16B25/00

    摘要： Methods of reading chemical arrays are provided. Aspects of the methods include reading an array at a first and second detector gain setting to produce linked data sets of an array, where each reading may be made using a different detector gain setting. Aspects of the methods further include extracting features from the linked data sets, where in certain embodiments a merged data set feature extraction protocol is employed. Aspects of the invention further include programming for operating devices, e.g., chemical array readers, as well as readers comprising such programming.

    摘要翻译： 提供读取化学阵列的方法。 方法的方面包括以第一和第二检测器增益设置读取阵列以产生阵列的相关联的数据集，其中可以使用不同的检测器增益设置来进行每次读取。 方法的方面还包括从链接的数据集中提取特征，其中在某些实施例中采用了合并的数据集特征提取协议。 本发明的方面还包括用于操作设备的编程，例如化学阵列读取器，以及包括这种编程的读取器。

    Obtaining measurements of light transmitted through an assay test strip
    4.
    发明申请
    Obtaining measurements of light transmitted through an assay test strip 审中-公开
    获得通过测试条带传输的光的测量值

    公开(公告)号：US20070122914A1

    公开(公告)日：2007-05-31

    申请号：US11290056

    申请日：2005-11-30

    申请人： Bo Curry

    发明人： Bo Curry

    IPC分类号： G01N33/543 ,  C12M1/34

    CPC分类号： G01N33/54366 ,  G01N21/8483 ,  G01N2035/00108

    摘要： Systems and methods of obtaining measurements of light transmitted through an assay test strip are described. In one aspect, a test strip is held. The top side of the test strip is illuminated with light. The illuminating light that is transmitted through the test strip and out from the bottom side of the test strip is detected. In another aspect, a diagnostic test system includes a detection system and a retainer. The detection system includes an optical detector that produces a measurement signal in response to light. The retainer holds a test strip so that the top side of the test strip is exposed for illumination and the bottom side of the test strip faces the optical detector.

    摘要翻译： 描述了通过测定测试条获得测量光的系统和方法。 在一个方面，保持测试条。 测试条的顶部用光照亮。 检测透过测试条并从测试条的底侧出来的照明光。 另一方面，诊断测试系统包括检测系统和保持器。 检测系统包括响应于光产生测量信号的光学检测器。 保持器保持测试条，使得测试条的顶侧暴露以进行照明，并且测试条的底侧面向光学检测器。

    CGH array quality assessment
    5.
    发明申请
    CGH array quality assessment 有权

    公开(公告)号：US20070082338A1

    公开(公告)日：2007-04-12

    申请号：US11193912

    申请日：2005-07-29

    申请人： Bo Curry ,  Jayati Ghosh

    发明人： Bo Curry ,  Jayati Ghosh

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： G06F19/20

    摘要： Methods, systems and computer readable media for characterizing quality of CGH arrays, including generating at least one metric for a CGH array that characterizes a property of the CGH array; repeating generation of the at least one metric for at least one additional CGH array; and comparing each metric across all CGH array metric values generated to identify a quality of any one of the CGH arrays characterized, relative to the CGH arrays characterized for that metric. Methods, systems and computer readable media for determining the quality of a CGH array, including calculating a spread of the derivative of log ratio value differences between consecutive probes representing consecutive positions along a chromosome, wherein ratio values are calculated from probe signals from a CGH array, as read by a reader on first and second channels thereof, or from probes signals from two CGH arrays, as read by a single channel reader. Methods, systems and computer readable media for qualifying a CGH array, including quantifying an interarray reproducibility metric characterizing selected sets of probe replicates. Methods, systems and computer readable media for qualifying a CGH array, including generating a Receiver Operating Characteristic (ROC) curve and analyzing false positive and true positive signals from a normal male sample and a normal female sample, as read by a reader on first and second channels thereof, or from one of a normal male sample and a normal female sample on the CGH array and the other of the normal male sample and normal female sample on a second CGH array, as read by a single-channel reader. Methods, systems and computer readable media for determining the quality of a CGH array, including segmenting, by copy number, log ratio signals from probes on the CGH array representing a genome; plotting a probability distribution of the segmented log ratio values; and quantifying separation between copy number peaks resulting from the plotting of the probability distribution.

    Card game system with automatic bet recognition
    7.
    发明申请
    Card game system with automatic bet recognition 审中-公开

    公开(公告)号：US20060160600A1

    公开(公告)日：2006-07-20

    申请号：US11102078

    申请日：2005-04-08

    申请人： Otho Hill ,  Bo Curry

    发明人： Otho Hill ,  Bo Curry

    IPC分类号： A63F9/24

    CPC分类号： G07F17/3293 ,  G07F17/32

    摘要： An exemplary embodiment of the invention includes a bet recognition system for use with a card game. A table is provided for playing a card game including a bet location for each player. An image capture device is positioned in proximity to the bet location and configured to capture an image of a player's bet. An image processor is coupled to the image capture device and configured to process the image by locating at least one chip and creating a signal representing the chip, comparing the signal to a plurality of stored signatures, and when a match occurs, generating a signal representing the bet. In one aspect, the image processor is configured to generate an error signal when unable to match a candidate signature with at least one of the stored signatures.

    Probe design methods and microarrays for comparative genomic hybridization and location analysis
    8.
    发明授权
    Probe design methods and microarrays for comparative genomic hybridization and location analysis 有权
    用于比较基因组杂交和位置分析的探针设计方法和微阵列

    公开(公告)号：US08036835B2

    公开(公告)日：2011-10-11

    申请号：US12797521

    申请日：2010-06-09

    申请人： Nicholas M. Sampas ,  Bo Curry ,  Peter Tsang ,  Doron Lipson ,  Zohar H. Yakhini

    发明人： Nicholas M. Sampas ,  Bo Curry ,  Peter Tsang ,  Doron Lipson ,  Zohar H. Yakhini

    IPC分类号： G06F7/00

    CPC分类号： C12Q1/6883 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00722 ,  G06F19/20

    摘要： Methods and systems for identifying and selecting nucleic acid probes for detecting a target with a nucleic acid probe array or comparative genome hybridization microarray, comprising selecting a plurality of potential target sequences, generating a plurality of candidate probes from the target sequences, filtering the plurality of candidate probes by analyzing candidate probes for selected probe properties in silico. Microarrays comprising probes selected by the methods of the invention are particularly useful for comparative genome hybridization and location analysis.

    摘要翻译： 用于鉴定和选择用于用核酸探针阵列或比较基因组杂交微阵列检测靶的核酸探针的方法和系统，包括选择多个潜在靶序列，从靶序列产生多个候选探针，过滤多个 通过分析选择的探针属性的候选探针在硅胶中的候选探针。 包含通过本发明方法选择的探针的微阵列特别可用于比较基因组杂交和位置分析。

    Negative control probes
    10.
    发明申请
    Negative control probes 审中-公开
    阴性对照探针

    公开(公告)号：US20070128611A1

    公开(公告)日：2007-06-07

    申请号：US11292588

    申请日：2005-12-02

    申请人： Charles Nelson ,  Bo Curry ,  Nicholas Sampas

    发明人： Charles Nelson ,  Bo Curry ,  Nicholas Sampas

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： C12Q1/6876 ,  C12Q1/6813 ,  C12Q2600/166 ,  G16B25/00 ,  G16B30/00 ,  C12Q2545/101

    摘要： In an embodiment, a method is included for generating a negative control probe sequence for an array including selecting biological probe sequences from the array randomly, generating a plurality of candidate probe sequences by randomly permuting the selected biological probe sequence, and screening the candidate probe sequences for sequence similarity to biologically occurring sequences. An embodiment also includes a computer-readable medium having computer-executable instructions for performing a method for generating a negative control probe sequences. Embodiments can also include an apparatus for generating a negative control sequence for an array, as well as negative control probes, sets of negative control probes and arrays comprising at least one negative control probe.

    摘要翻译： 在一个实施方案中，包括用于产生用于阵列的阴性对照探针序列的方法，包括随机选择阵列中的生物探针序列，通过随机置换所选生物探针序列产生多个候选探针序列，并筛选候选探针序列 与生物发生序列的序列相似性。 实施例还包括具有用于执行生成负控制探针序列的方法的计算机可执行指令的计算机可读介质。 实施例还可以包括用于产生阵列的负控制序列的装置，以及阴性对照探针，负控制探针组和包括至少一个阴性对照探针的阵列。