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33 条记录 (耗时 0.024 秒)

    Analyzing CGH data to identify aberrations
    1.
    发明申请
    Analyzing CGH data to identify aberrations 审中-公开
    分析CGH数据以识别畸变

    公开(公告)号：US20070031883A1

    公开(公告)日：2007-02-08

    申请号：US11545962

    申请日：2006-10-10

    申请人： Robert Kincaid ,  Jayati Ghosh ,  Bo Curry

    发明人： Robert Kincaid ,  Jayati Ghosh ,  Bo Curry

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： G16B25/00 ,  G16B40/00

    摘要： Methods, systems and computer readable media for calling out genetic aberrations. Log ratio noise associated with log ratio signals read from respective probes on at least one array for signals representative of the same chromosomal locations in a test sample of nucleic acids and a reference sample of nucleic acids applied to the at least one array are estimated. Outliers for log ratio values from the reference sample to outliers for log ratio values from the test sample are compared. A copy number of one or more of the chromosomal locations in the test sample is outputted relative to the reference sample for viewing by a user.

    摘要翻译： 用于呼出遗传畸变的方法，系统和计算机可读介质。 估计与在至少一个阵列上从相应探针读取的对数比率信号相关联的对数比噪声，所述信号表示核酸的测试样品和应用于至少一个阵列的核酸的参考样品中的相同染色体位置的信号。 比较从参考样本到测试样本对数比值的异常值的对数比值的异常值。 测试样品中的一个或多个染色体位置的拷贝数相对于参考样品被输出以供用户观看。

    Significance analysis using data smoothing with shaped response functions
    3.
    发明申请
    Significance analysis using data smoothing with shaped response functions 审中-公开
    使用具有形状响应函数的数据平滑的意义分析

    公开(公告)号：US20070099227A1

    公开(公告)日：2007-05-03

    申请号：US11607786

    申请日：2006-11-30

    申请人： Bo Curry ,  Jayati Ghosh

    发明人： Bo Curry ,  Jayati Ghosh

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： G16B40/00 ,  G16B25/00

    摘要： Methods, systems and computer readable media for analyzing data. A variable width window is applied to data points from the data which are ordered to correspond to locations along a chromosome of targeted nucleotide sequences whose relative abundances are represented by the data points. The window applied is a moving window, the width of which is variable upon movement of the window to capture a fixed number of the data points, wherein the width is symmetrical about the data point to which a weighted average is to be assigned. A response function is applied to the data points captured in the window. The response function is symmetrical about the data point to which a weighted average is to be assigned.

    摘要翻译： 用于分析数据的方法，系统和计算机可读介质。 可变宽度窗口被应用于从数据排列的数据点，对应于沿着相对丰度由数据点表示的目标核苷酸序列的染色体的位置。 应用的窗口是移动窗口，其宽度在窗口移动时变化以捕获固定数量的数据点，其中宽度对于要分配加权平均数据点的对称关系。 响应函数应用于窗口中捕获的数据点。 响应函数对应于要分配加权平均数据的数据点。

    Instrument control system and methods
    4.
    发明授权
    Instrument control system and methods 有权
    仪器控制系统及方法

    公开(公告)号：US08332737B2

    公开(公告)日：2012-12-11

    申请号：US12492487

    申请日：2009-06-26

    申请人： Peter G. Webb ,  Jayati Ghosh ,  Bo Curry

    发明人： Peter G. Webb ,  Jayati Ghosh ,  Bo Curry

    IPC分类号： G06F11/00 ,  G06F11/30

    CPC分类号： G06F11/3055 ,  G06F11/0736 ,  G06F11/0748 ,  G06F11/076 ,  G06F11/3013 ,  G06F11/3058

    摘要： Methods, systems and computer readable media for controlling an instrument in communication with a host computer are provided. Operations of an instrument that must be completed on schedule are controlled via an embedded controller embedded in the instrument. A complete status packet is sent to a host computer from the embedded controller. Periodically, the embedded controller repeats the sending of a complete status packet to the host computer, wherein status values in the complete status packet are updated with each iteration of sending a complete status packet.

    摘要翻译： 提供了用于控制与主计算机通信的仪器的方法，系统和计算机可读介质。 必须按计划完成的仪器的操作通过嵌入仪器中的嵌入式控制器进行控制。 完整的状态包从嵌入式控制器发送到主机。 周期性地，嵌入式控制器重复向主计算机发送完整的状态分组，其中通过每次发送完整状态分组的迭代来更新完整状态分组中的状态值。

    CGH array quality assessment
    5.
    发明申请
    CGH array quality assessment 有权

    公开(公告)号：US20070082338A1

    公开(公告)日：2007-04-12

    申请号：US11193912

    申请日：2005-07-29

    申请人： Bo Curry ,  Jayati Ghosh

    发明人： Bo Curry ,  Jayati Ghosh

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： G06F19/20

    摘要： Methods, systems and computer readable media for characterizing quality of CGH arrays, including generating at least one metric for a CGH array that characterizes a property of the CGH array; repeating generation of the at least one metric for at least one additional CGH array; and comparing each metric across all CGH array metric values generated to identify a quality of any one of the CGH arrays characterized, relative to the CGH arrays characterized for that metric. Methods, systems and computer readable media for determining the quality of a CGH array, including calculating a spread of the derivative of log ratio value differences between consecutive probes representing consecutive positions along a chromosome, wherein ratio values are calculated from probe signals from a CGH array, as read by a reader on first and second channels thereof, or from probes signals from two CGH arrays, as read by a single channel reader. Methods, systems and computer readable media for qualifying a CGH array, including quantifying an interarray reproducibility metric characterizing selected sets of probe replicates. Methods, systems and computer readable media for qualifying a CGH array, including generating a Receiver Operating Characteristic (ROC) curve and analyzing false positive and true positive signals from a normal male sample and a normal female sample, as read by a reader on first and second channels thereof, or from one of a normal male sample and a normal female sample on the CGH array and the other of the normal male sample and normal female sample on a second CGH array, as read by a single-channel reader. Methods, systems and computer readable media for determining the quality of a CGH array, including segmenting, by copy number, log ratio signals from probes on the CGH array representing a genome; plotting a probability distribution of the segmented log ratio values; and quantifying separation between copy number peaks resulting from the plotting of the probability distribution.

    INSTRUMENT CONTROL SYSTEM AND METHODS
    6.
    发明申请
    INSTRUMENT CONTROL SYSTEM AND METHODS 有权
    仪器控制系统及方法

    公开(公告)号：US20100332953A1

    公开(公告)日：2010-12-30

    申请号：US12492487

    申请日：2009-06-26

    申请人： Peter G. Webb ,  Jayati Ghosh ,  Bo Curry

    发明人： Peter G. Webb ,  Jayati Ghosh ,  Bo Curry

    IPC分类号： H03M13/09

    CPC分类号： G06F11/3055 ,  G06F11/0736 ,  G06F11/0748 ,  G06F11/076 ,  G06F11/3013 ,  G06F11/3058

    摘要： Methods, systems and computer readable media for controlling an instrument in communication with a host computer are provided. Operations of an instrument that must be completed on schedule are controlled via an embedded controller embedded in the instrument. A complete status packet is sent to a host computer from the embedded controller Periodically, the embedded controller repeats the sending of a complete status packet to the host computer, wherein status values in the complete status packet are updated with each iteration of sending a complete status packet.

    摘要翻译： 提供了用于控制与主计算机通信的仪器的方法，系统和计算机可读介质。 必须按计划完成的仪器的操作通过嵌入仪器中的嵌入式控制器进行控制。 完整的状态包从嵌入式控制器发送到主计算机周期性地，嵌入式控制器重复向主计算机发送完整的状态包，其中在完成状态包中的状态值被更新，每次迭代发送完整状态 包。

    Insertable nanoscale FET probe
    9.
    发明申请
    Insertable nanoscale FET probe 失效
    可插入纳米级FET探头

    公开(公告)号：US20070186628A1

    公开(公告)日：2007-08-16

    申请号：US11351515

    申请日：2006-02-10

    申请人： Bo Curry ,  Sungsoo Yi

    发明人： Bo Curry ,  Sungsoo Yi

    IPC分类号： G01B5/28

    CPC分类号： G01Q70/12 ,  G01Q60/30 ,  G01Q60/42

    摘要： The nanoscale FET probe comprises a cantilever element and, at one end of the cantilever element, a nanowire that extends from the cantilever element. The nanowire is electrically connected to the cantilever element at at least one of the ends of the nanowire. The nanowire is capable of being coated with molecules of a capture agent along at least part of its length.

    摘要翻译： 纳米级FET探针包括悬臂元件，并且在悬臂元件的一端具有从悬臂元件延伸的纳米线。 纳米线在纳米线的至少一个端部处电连接到悬臂元件。 纳米线能够沿着其长度的至少一部分被包裹有捕获剂的分子。

    Extended dynamic range reading of chemical arrays
    10.
    发明申请
    Extended dynamic range reading of chemical arrays 审中-公开
    扩大化学阵列的动态范围读数

    公开(公告)号：US20070178480A1

    公开(公告)日：2007-08-02

    申请号：US11344773

    申请日：2006-01-31

    申请人： John F. Corson ,  Bo Curry ,  Charles Troup ,  Xiangyang Zhou

    发明人： John F. Corson ,  Bo Curry ,  Charles Troup ,  Xiangyang Zhou

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： G16B25/00

    摘要： Methods of reading chemical arrays are provided. Aspects of the methods include reading an array at a first and second detector gain setting to produce linked data sets of an array, where each reading may be made using a different detector gain setting. Aspects of the methods further include extracting features from the linked data sets, where in certain embodiments a merged data set feature extraction protocol is employed. Aspects of the invention further include programming for operating devices, e.g., chemical array readers, as well as readers comprising such programming.

    摘要翻译： 提供读取化学阵列的方法。 方法的方面包括以第一和第二检测器增益设置读取阵列以产生阵列的相关联的数据集，其中可以使用不同的检测器增益设置来进行每次读取。 方法的方面还包括从链接的数据集中提取特征，其中在某些实施例中采用了合并的数据集特征提取协议。 本发明的方面还包括用于操作设备的编程，例如化学阵列读取器，以及包括这种编程的读取器。