Methods to make and use antibodies of improved cross-reactivity
    3.
    发明申请
    Methods to make and use antibodies of improved cross-reactivity 审中-公开
    制备和使用改进的交叉反应性的抗体的方法

    公开(公告)号:US20050272131A1

    公开(公告)日:2005-12-08

    申请号:US11069079

    申请日:2005-03-01

    IPC分类号: C07K16/12 C12P21/04 C12P21/06

    CPC分类号: C07K16/1242

    摘要: The present invention relates to methods of generating antibodies of improved cross-reactivity against antigens that give rise to immunotypic variations in infectious organisms. The methods include immunizing animals with multiple immunogen preparations that are derived from the antigen of interest. The present invention also includes methods of use of the antibodies of improved cross-reactivity, and assays and kits for employing such methods.

    摘要翻译: 本发明涉及生成针对抗原的交叉反应性抗体的抗体的方法,所述抗体在感染性生物体中产生免疫型变异。 所述方法包括用衍生自感兴趣的抗原的多种免疫原制剂免疫动物。 本发明还包括使用改进的交叉反应性的抗体的方法,以及采用这些方法的测定和试剂盒。