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公开(公告)号:US08440220B2
公开(公告)日:2013-05-14
申请号:US10420428
申请日:2003-04-22
申请人: Robert M. Gale , Thomas M. Stein , Jay Audett , Jane Stepic , Joseph B. Phipps , Michel J. N. Cormier
发明人: Robert M. Gale , Thomas M. Stein , Jay Audett , Jane Stepic , Joseph B. Phipps , Michel J. N. Cormier
IPC分类号: A61K9/70
CPC分类号: A61K9/7092 , A61K9/7061 , A61K31/4468 , A61K31/4535 , A61K45/06 , A61K2300/00
摘要: A transdermal analgesic system having reduced potential for abuse, wherein the system provides for the controlled release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic when the dosage form is subject to abuse is disclosed.
摘要翻译: 一种具有降低的滥用可能性的透皮镇痛系统,其中所述系统以足以在剂型受到滥用时提供拮抗剂与镇痛剂的滥用限制释放速率比的速率提供拮抗剂的受控释放。
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公开(公告)号:US20070098772A1
公开(公告)日:2007-05-03
申请号:US11525684
申请日:2006-09-22
申请人: Tyler Westcott , Jane Stepic , Delphine Imbert , Jay Audett , Jianye Wen , Allison Luciano , Eric Silverberg , Paul Foreman
发明人: Tyler Westcott , Jane Stepic , Delphine Imbert , Jay Audett , Jianye Wen , Allison Luciano , Eric Silverberg , Paul Foreman
CPC分类号: A61K9/7061 , A61K31/4439 , A61K31/56 , C09J7/255 , C09J7/385 , C09J133/06 , C09J2467/006
摘要: A system for transdermal delivery of norelgestromin (NGMN) to an individual. The system has a high NGMN loading with suitable permeation enhancers to effect therapeutic flux rate. Polyacrylate drug reservoir with the NGMN and high loading of one or more of permeation enhancers and NGMN dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties. Estrogen can be delivered with the NGMN.
摘要翻译: 将norelgestromin(NGMN)透皮递送给个体的系统。 该系统具有高的NGMN负载,具有合适的渗透增强剂以实现治疗通量。 具有NGMN的聚丙烯酸酯药物储存器和溶解在其中的一种或多种渗透促进剂和NGMN的高负荷提供了所需的粘合特性和有效的经皮治疗性质。 雌激素可与NGMN一起递送。
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公开(公告)号:US20090004257A1
公开(公告)日:2009-01-01
申请号:US12174086
申请日:2008-07-16
IPC分类号: A61K9/70 , A61K31/445
CPC分类号: A61K31/4468 , A61K9/0014 , A61K9/703 , A61K9/7038 , A61K9/7061 , A61K9/7084 , A61K31/4535 , A61K47/14 , A61K47/22 , A61K47/32 , A61K47/34
摘要: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
摘要翻译: 公开了一种方法和非速率控制的整体式亚饱和贴片,用于通过皮肤在延长的时间段内经皮给药芬太尼及其类似物用于止痛目的。
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公开(公告)号:US20050208117A1
公开(公告)日:2005-09-22
申请号:US11128636
申请日:2005-05-13
IPC分类号: A61K9/70 , A61K31/445
CPC分类号: A61K9/7061 , A61K31/445
摘要: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
摘要翻译: 公开了一种方法和非速率控制的整体式亚饱和贴片,用于通过皮肤在延长的时间段内经皮给药芬太尼及其类似物用于止痛目的。
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