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1.发明授权Method of cleaning hollow fiber components of a dialyzer with chloro fluorocarbon compositions stabilized by epoxidized fatty acid glycerides or esters 失效通过环氧化的脂肪酸甘油酯或硫酸酯稳定的氯氟化碳组合物清洁中和纤维组分的方法
公开(公告)号：US5114608A
公开(公告)日：1992-05-19
申请号：US596880
申请日：1990-10-12
CPC分类号： C11D7/261 , C11D7/5018 , C11D7/5081 , C11D7/266 , C11D7/28
摘要： A method of stabilizing chlorofluorocarbon compositions thereby is provided. The stabilized composition comprises a chlorofluorocarbon and a sufficient amount of an epoxidized, generally high molecular weight stabilizer having an oxirane content sufficient to effectively stabilize the chlorofluorocarbon. The stabilizer is preferably an epoxidized oil having a molecular weight in the range of about 300 to about 1,500 and an oxirane content of at least about 4%. The method includes the step of adding a sufficient amount of such a stabilizer to the chloroflurocarbon composition. The chlorofluorocarbon composition typically comprises chlorofluoromethane, chlorofluoroethane, mixtures thereof or a chlorofluorocarbon-alcohol azeotropic solution. Also provided is an improved continuous dialyzer cleaning method utilizing the stabilized chlorofluorocarbon composition.
摘要翻译： 提供了一种稳定氯氟烃组合物的方法。 稳定的组合物包含氯氟烃和足量的具有足以有效稳定氯氟烃的环氧乙烷含量的环氧化，通常高分子量的稳定剂。 稳定剂优选为分子量在约300至约1500的环氧化物油和至少约4％的环氧乙烷含量的环氧化油。 该方法包括向氯氟烃组合物中加入足够量的这种稳定剂的步骤。 氯氟烃组合物通常包括氯氟甲烷，氯氟乙烷，其混合物或氯氟烃 - 醇共沸溶液。 还提供了利用稳定的氯氟烃组合物的改进的连续透析器清洗方法。
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公开(公告)号：US4300559A
公开(公告)日：1981-11-17
申请号：US151448
申请日：1980-05-19
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , A61K35/14 , A61L33/00 , A61M1/36 , A61M5/14 , C08K5/12 , A61M5/00
CPC分类号： A61J1/10 , A61L33/0005 , A61L33/0052 , A61M1/3687 , C08K5/12 , Y10S128/24
摘要： Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable plasticizer such as di-2-ethylhexylphthalate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.
摘要翻译： 与血液相容的无氯聚合物如柔性无毒的可灭菌的聚酯塑料制剂可含有5-70重量％的血液可提取增塑剂，例如邻苯二甲酸二-2-乙基己基酯，以引起储存的血液 与不含增塑剂的相应聚合物相比，与聚合物接触以显示惊人的低溶血速率。 因此，可以有利地由这些聚合物制造血袋，管道和其它医用血液接触装置。
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3.发明授权Blood compatible polymers and medical devices made therefrom containing dioctyladipate plasticizer 失效由血液相容的聚合物和由此制成的医疗器械含有二辛酸二辛酯增塑剂
公开(公告)号：US4286597A
公开(公告)日：1981-09-01
申请号：US142290
申请日：1980-04-21
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , A61K35/14 , A61L33/00 , A61M1/36 , A61M5/14 , C08K5/12 , A61M5/00
CPC分类号： A61J1/10 , A61L33/0005 , A61L33/0052 , A61M1/3687 , C08K5/12 , Y10S128/24
摘要： Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable plasticizer such as di-2-ethylhexyladipate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.
摘要翻译： 血液相容的无氯聚合物如柔性无毒的可消毒的聚酯塑料制剂可以含有5-70重量％的血液可提取的增塑剂，例如己二酸二-2-乙基己酯，以引起储存的血液 与不含增塑剂的相应聚合物相比，与聚合物接触以显示惊人的低溶血速率。 因此，可以有利地由这些聚合物制造血袋，管道和其它医用血液接触装置。
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公开(公告)号：US5382526A
公开(公告)日：1995-01-17
申请号：US326449
申请日：1989-03-17
CPC分类号： A61J1/10
摘要： A blood bag comprises a plastic polyvinyl chloride formulation in which the polyvinyl chloride formulation contains from 5 to 30 percent by weight of a first plasticizer material which is essentially nonextractable by blood plasma stored in the bag up to 35 days at about 4.degree. C.; and from 10 to 25 percent by weight of a second plasticizer which is significantly extracted by blood plasma stored in the bag up to 35 days at about 4.degree. C.
摘要翻译： 血袋包括塑料聚氯乙烯制剂，其中聚氯乙烯制剂含有5-30重量％的第一增塑剂材料，其在大约4℃下存储在袋中最多35天的血浆基本上是不可提取的; 和10至25重量％的第二增塑剂，其在约4℃下存储在袋中的血浆中显着提取至多35天。
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5.发明授权Blood component storage container and method utilizing a polyvinyl chloride plastic formulation free or essentially free of leachable materials 失效血液成分储存容器和使用不含或基本上不含可浸出物质的聚氯乙烯塑料制剂的方法
公开(公告)号：US4505708A
公开(公告)日：1985-03-19
申请号：US424679
申请日：1982-09-27
申请人： Henry M. Gajewski , Paul Measells
发明人： Henry M. Gajewski , Paul Measells
CPC分类号： A61L31/143 , Y10S128/24
摘要： A method of storing blood components uses a blood component storage container which is made of a plasticized polyvinyl chloride formulation which includes a heat stabilizer system selected from the group consisting of salts of C.sub.10 to C.sub.26 saturated fatty acids present in an amount of less than about one percent by weight of the composition. Surprisingly, use of only minimal amounts of these higher molecular weight fatty acids results in an effectively heat stabilized product suited for mass production techniques. As a result, the total amount of the heat stabilizer which can possibly leach into blood plasma is significantly reduced. The material from which the container is made preferably includes an effective amount of a plasticizer which is also essentially nonextractable in blood plasma.
摘要翻译： 存储血液成分的方法使用由塑化聚氯乙烯制剂制成的血液成分储存容器，所述血液成分储存容器包括热稳定剂系统，所述热稳定剂体系选自C 10〜C 26饱和脂肪酸的盐，所述饱和脂肪酸的含量小于约1 重量百分比的组合物。 令人惊讶的是，仅使用最小量的这些较高分子量的脂肪酸导致适合于批量生产技术的有效的热稳定产品。 结果，可能浸出血浆的热稳定剂的总量显着降低。 制造容器的材料优选包含有效量的也在血浆中基本上不可提取的增塑剂。
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公开(公告)号：US4154244A
公开(公告)日：1979-05-15
申请号：US853738
申请日：1977-11-21
CPC分类号： A61M25/1027 , A61L29/041 , A61L29/049 , A61L29/141
摘要： A balloon-type catheter is disclosed having a catheter shank made of a block copolymer having thermoplastic rubber characteristics with a central block of ethylene-butylene copolymer and terminal blocks of polystyrene. The inflatable balloon member, and preferably the distal Y-member, of the catheter are made of an elastic composition which includes the same or a similar block copolymer, in the presence of polystyrene or equivalent material as a tackifying agent, polypropylene, and an oil-type plasticizer.
摘要翻译： 公开了一种气球型导管，其具有由具有热塑性橡胶特性的嵌段共聚物制成的导管柄，其具有乙烯 - 丁烯共聚物的中心嵌段和聚苯乙烯的端基。 导管的可膨胀气囊构件，优选地，远端Y构件由弹性组合物制成，弹性组合物包含相同或相似的嵌段共聚物，在聚苯乙烯或作为增粘剂的当量材料，聚丙烯和油 型增塑剂。
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7.发明授权Method of storing red blood cells which minimizes both red blood cell hemolysis and exposure to blood extractable plasticizers 失效储存红细胞的方法，使红血细胞溶血和暴露于可提取血液的增塑剂最小化
公开(公告)号：US4507387A
公开(公告)日：1985-03-26
申请号：US471745
申请日：1983-03-09
CPC分类号： A61J1/1487 , A61J1/10 , A61J1/1468
摘要： A method of storing a quantity of red blood cells uses a blood bag which comprises a plastic polyvinyl chloride formulation which contains from 5 to 30 percent by weight of a first plasticizer material which is essentially nonextractable by blood plasma stored in the bag up to 35 days at about 4.degree. C.; and from 10 to 25 percent by weight of a second plasticizer which is significantly extracted by blood plasma stored in the bag up to 35 days at about 4.degree. C. and which, upon leaching, is capable of suppressing the formation of plasma hemoglobin.
摘要翻译： 存储一定数量的红细胞的方法使用血袋，该血袋包括塑料聚氯乙烯制剂，其含有5至30重量％的第一增塑剂材料，其基本上不被储存在袋中的血浆提取至多35天 约4℃。 和10至25重量％的第二增塑剂，其在约4℃下储存在袋中的血浆中显着提取至多35天，并且其在浸出时能够抑制血浆血红蛋白的形成。
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8.发明授权Catheter made of a thermoplastic material having improved softness and low friction 失效由热塑性材料制成的导管具有改进的柔软度和低摩擦力
公开(公告)号：US4198983A
公开(公告)日：1980-04-22
申请号：US900965
申请日：1978-04-28
CPC分类号： A61M25/1029 , A61L29/041 , A61L29/049 , A61L29/141 , A61M25/1034 , A61M25/1036
摘要： A catheter, preferably a balloon-type catheter, is disclosed in which the catheter shaft is made of a thermoplastic material and thus may be extrudable, the shaft consisting essentially of (a) from 40 to 70 percent by weight of an elastic composition which comprises: from 50 to 99.5 percent by weight of a block copolymer having thermoplastic rubber characteristics with a central, rubbery polyolefin block and terminal blocks of polystyrene, and optionally including up to about 45 percent by weight of polypropylene, plus from 0.5 to 10 percent by weight of a cross-linked organic silicone elastomer; and (b) from 30 to 60 percent by weight of a hydrophobic oil-type plasticizer to provide the desired degree of softness to said elastic composition.
摘要翻译： 公开了导管，优选气囊型导管，其中导管轴由热塑性材料制成，因此可以是可挤出的，该轴基本上由（a）40至70重量％的弹性组合物组成，其包含 ：50至99.5重量％的具有热塑性橡胶特性的嵌段共聚物，其具有中心的橡胶聚烯烃嵌段和聚苯乙烯的封端，并且任选地包括至多约45重量％的聚丙烯，加上0.5至10重量％ 的交联有机硅氧烷弹性体; 和（b）30-60重量％的疏水性油型增塑剂，以提供所需弹性组合物的柔软度。
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