公开(公告)号：US20060029983A1

公开(公告)日：2006-02-09

申请号：US11040218

申请日：2005-01-21

申请人： Robert Oakley ,  Christine Hudson ,  Marc Caron ,  Raul Gainetdinov ,  Robert Lefkowitz ,  Richard Premont

发明人： Robert Oakley ,  Christine Hudson ,  Marc Caron ,  Raul Gainetdinov ,  Robert Lefkowitz ,  Richard Premont

IPC分类号： G01N33/567 ,  G01N33/53

CPC分类号： C07K14/705 ,  C07K14/723 ,  C07K2319/033 ,  C12N9/1205 ,  G01N33/573 ,  G01N2333/726 ,  G01N2500/10

摘要： The present invention relates to methods of treating disease by altering G protein coupled receptor kinase (GRK) 6. This may be done by altering the expression or activity of the protein, for example. The present invention may be used for disease diagnosis, by detecting the expression or activity of GRK6. The present invention relates to a GRK6 deficient mouse, GRK6 splice variants, and methods of use. The present invention also relates to methods of identifying compounds that alter GRK6 activity. The present invention relates to disease treatment by altering GRK6 expression or activity.

摘要翻译： 本发明涉及通过改变G蛋白偶联受体激酶（GRK）6来治疗疾病的方法。这可以通过例如改变蛋白质的表达或活性来进行。 通过检测GRK6的表达或活性，可以将本发明用于疾病诊断。 本发明涉及GRK6缺陷小鼠，GRK6剪接变体和使用方法。 本发明还涉及鉴定改变GRK6活性的化合物的方法。 本发明涉及通过改变GRK6表达或活性的疾病治疗。