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    Stable plurilamellar vesicles
    1.
    发明授权
    Stable plurilamellar vesicles 失效
    稳定的多层囊泡

    公开(公告)号：US5030453A

    公开(公告)日：1991-07-09

    申请号：US660573

    申请日：1984-10-12

    申请人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    发明人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    IPC分类号： A61K9/127

    CPC分类号： A61K9/1277 ,  A61K9/127

    摘要： A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the concentration of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.

    摘要翻译： 描述了称为稳定多层囊泡（SPLV）的新的和基本上改进的类型的脂质囊泡，以及制备相同的方法和用于鉴定其的X射线衍射方法。 SPLV的特征在于包围含有一个或多个截留的溶质的水性隔室的脂质双层，每个水分隔室中的这种溶质的浓度基本上等于用于制备SPLV的溶质的浓度。 SPLV的双层基本上是非压缩的。 SPLV在储存期间是稳定的，并且可以在体内用于化合物的持续释放和疾病的治疗。

    Stable plurilamellar vesicles
    2.
    发明授权
    Stable plurilamellar vesicles 失效
    稳定的多层囊泡

    公开(公告)号：US5169637A

    公开(公告)日：1992-12-08

    申请号：US679569

    申请日：1991-04-02

    申请人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    发明人： Robert P. Lenk ,  Michael W. Fountain ,  Andrew S. Janoff ,  Mircea C. Popescu ,  Steven J. Weiss ,  Richard S. Ginsberg ,  Marc J. Ostro ,  Sol M. Gruner

    IPC分类号： A61K9/127

    CPC分类号： A61K9/127 ,  A61K9/1277

    摘要： A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the emunization of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.

    摘要翻译： 描述了称为稳定多层囊泡（SPLV）的新的和基本上改进的类型的脂质囊泡，以及制备相同的方法和用于鉴定其的X射线衍射方法。 SPLV的特征在于包裹含有一个或多个截留的溶质的水性隔室的脂质双层，每个水分隔室中的这种溶质的浓度基本上等于用于制备SPLV的溶质的排出。 SPLV的双层基本上是非压缩的。 SPLV在储存期间是稳定的，并且可以在体内用于化合物的持续释放和疾病的治疗。

    Pressure cryocooling protein crystals
    4.
    发明授权
    Pressure cryocooling protein crystals 有权
    压力低温冷冻蛋白晶体

    公开(公告)号：US08030449B2

    公开(公告)日：2011-10-04

    申请号：US11700237

    申请日：2007-01-31

    申请人： Chae Un Kim ,  Sol M. Gruner

    发明人： Chae Un Kim ,  Sol M. Gruner

    IPC分类号： C07K1/00 ,  G01N31/00

    CPC分类号： C30B29/58 ,  C30B7/00 ,  C30B33/00

    摘要： Preparation of cryocooled protein crystal is provided by use of helium pressurizing and cryocooling to obtain cryocooled protein crystal allowing collection of high resolution data and by heavier noble gas (krypton or xenon) binding followed by helium pressurizing and cryocooling to obtain cryocooled protein crystal for collection of high resolution data and SAD phasing simultaneously. The helium pressurizing is carried out on crystal coated to prevent dehydration or on crystal grown in aqueous solution in a capillary.

    摘要翻译： 通过使用氦加压和低温冷却来制备低温冷冻蛋白晶体，以获得低浓度的蛋白质晶体，从而可以收集高分辨率数据，并通过较重的惰性气体（氪或氙）结合，然后进行氦加压和低温冷却，获得低温冷冻蛋白晶体，以收集 高分辨率数据和SAD定相同步。 氦加压在晶体涂层上进行，以防止脱水或在毛细管中在水溶液中生长的晶体。