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公开(公告)号：US5710174A
公开(公告)日：1998-01-20
申请号：US483213
申请日：1995-06-07
申请人： Robert R. West , Teresa Martinez , Hank R. Franklin , Paul D. Bishop , Birgitte R.o slashed.mer Rassing
发明人： Robert R. West , Teresa Martinez , Hank R. Franklin , Paul D. Bishop , Birgitte R.o slashed.mer Rassing
IPC分类号： A61K31/365 , A61K38/48 , A61K38/49 , C07D313/00 , C12P17/12 , A61K31/335
CPC分类号： C12P17/12 , A61K31/365 , A61K38/484 , A61K38/49 , C07D313/00
摘要： A compound that is useful for inhibiting FXIIIa catalysis of fibrin cross-linking, and related pharmaceutical compositions and methods, are disclosed. The compound and compositions may be advantageously used to enhance fibrinolysis and resolution of blood clots.
摘要翻译： 公开了可用于抑制纤维蛋白交联的FXIIIa催化的化合物，以及相关的药物组合物和方法。 该化合物和组合物可有利地用于增强血栓的纤维蛋白溶解和分解。
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公开(公告)号：US07208578B2
公开(公告)日：2007-04-24
申请号：US11133823
申请日：2005-05-20
IPC分类号： C07K14/00
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to polynucleotide and polypeptide molecules for zacrp2, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp2 polypeptides.
摘要翻译： 本发明涉及用于zacrp2的多核苷酸和多肽分子，其是具有胶原样结构域和C1q结构域的蛋白家族的新成员。 编码它们的多肽和多核苷酸参与二聚化或低聚反应，并可用于其研究。 本发明还包括针对zacrp2多肽的抗体。
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公开(公告)号：US07179787B2
公开(公告)日：2007-02-20
申请号：US10990246
申请日：2004-11-16
申请人： Paul O. Sheppard , Paul D. Bishop
发明人： Paul O. Sheppard , Paul D. Bishop
CPC分类号： C07K14/52 , A61K38/00 , C07K14/4702 , C07K2319/00 , C12Q1/6888 , C12Q2600/158
摘要： The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1–3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
摘要翻译： 本发明提供新的用途，称为“Zven”的新家族人类蛋白质的两个成员，作为刺激胃肠收缩力，胃排空，肠道运输和治疗胃轻瘫的药物。位于人染色体3p21.1中的Zven1基因 -3p14.3，表达于睾丸组织和外周血淋巴细胞。
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公开(公告)号：US07115559B2
公开(公告)日：2006-10-03
申请号：US10489082
申请日：2002-09-10
申请人： Paul D. Bishop
发明人： Paul D. Bishop
IPC分类号： A61K38/36 , C07K14/745
CPC分类号： A61K38/45 , A61K38/14 , A61K2300/00
摘要： Use of factor XIII for treating coumarin-induced hemorrhage or bleeding. The coumarin may be warfarin or dicoumarol. A patient having coumarin-induced bleeding is treated with factor XIII alone or in conjunction with vitamin K.
摘要翻译： 使用因子XIII治疗香豆素引起的出血或出血。 香豆素可以是华法林或二西他赛。 使用单因素XIII或维生素K联合治疗香豆素引起的出血患者。
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公开(公告)号：US06780411B2
公开(公告)日：2004-08-24
申请号：US10053316
申请日：2002-01-17
IPC分类号： A61K3800
CPC分类号： A61L24/106 , A61L24/043
摘要： Tissue sealant compositions containing human recombinant fibrinogen, human recombinant factor XIII and human recombinant thrombin. Also disclosed are preferred formulations and uses therefore.
摘要翻译： 含有人重组纤维蛋白原，人重组因子XIII和人重组凝血酶的组织密封剂组合物。 因此也公开了优选的制剂和用途。
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公开(公告)号：US06762044B2
公开(公告)日：2004-07-13
申请号：US10177308
申请日：2002-06-21
申请人： Paul O. Sheppard , Nand Baindur , Paul D. Bishop
发明人： Paul O. Sheppard , Nand Baindur , Paul D. Bishop
IPC分类号： C12N948
CPC分类号： C12N9/6489 , A61K38/00
摘要： The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for MAPP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAPP polypeptides.
摘要翻译： 本发明涉及针对MAPP的多核苷酸和多肽分子及其变体，其是解聚酶蛋白酶的新成员。 多肽和编码它们的多核苷酸是细胞 - 细胞相互作用调控，可用于递送和治疗。 本发明还包括针对MAPP多肽的抗体。
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公开(公告)号：US06645938B2
公开(公告)日：2003-11-11
申请号：US09757860
申请日：2001-01-10
IPC分类号： A61K3800
摘要： A compound and method for using compound-D SEQ ID NO:1 to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
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公开(公告)号：US06627729B1
公开(公告)日：2003-09-30
申请号：US09404417
申请日：1999-09-23
IPC分类号： C07K706
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.
摘要翻译： 本发明涉及用于标记为TML肽的新型肽片段的多核苷酸，肽，变体及其用途。 肽片段的结合已经显示在肾脏和小肠中。 本发明还包括激动剂，拮抗剂，变体，抗体，表达编码新型TML肽的cDNA的宿主细胞和使用新型TML肽增加消化蛋白和激素的胃动力和分泌的方法。
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公开(公告)号：US06620909B1
公开(公告)日：2003-09-16
申请号：US09552204
申请日：2000-04-19
IPC分类号： C07K1400
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to polynucleotide and polypeptide molecules for zacrp2, a novel member of the family of proteins bearing a collagen-like domain and a Clq domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp2 polypeptides.
摘要翻译： 本发明涉及用于zacrp2的多核苷酸和多肽分子，其是具有胶原样结构域和Clq结构域的蛋白家族的新成员。 编码它们的多肽和多核苷酸参与二聚化或低聚反应，并可用于其研究。 本发明还包括针对zacrp2多肽的抗体。
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公开(公告)号：US06420154B1
公开(公告)日：2002-07-16
申请号：US09632098
申请日：2000-08-02
申请人： Paul O. Sheppard , Nand Baindur , Paul D. Bishop
发明人： Paul O. Sheppard , Nand Baindur , Paul D. Bishop
IPC分类号： C12N948
CPC分类号： C12N9/6489 , A61K38/00
摘要： The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for MAPP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAPP polypeptides.
摘要翻译： 本发明涉及针对MAPP的多核苷酸和多肽分子及其变体，其是解聚酶蛋白酶的新成员。 多肽和编码它们的多核苷酸是细胞 - 细胞相互作用调控，可用于递送和治疗。 本发明还包括针对MAPP多肽的抗体。
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